Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
PRS4
Systematic Name
YBL068W
Strain
S288c
Description
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>PRS4 YBL068W
ATGAATTCAGAGTCTCGAGAAGATATGGCTATAAATAGTATCAAATTGCTAGCGGGAAAC
TCCCATCCTGATTTGGCTGAACAAATATCGAAAAAGTTAGGTATTCCACTTTCCAAAGTT
GGTGTGTACCAGTATTCTAATAAAGAAACCTCTGTCACCATAGGTGAGAGCCTTCGCGAC
GAAGATGTGTATATTATCCAAACTGGAATAGGTGAACAAGAAATTAATGATTTCTTGATG
GAATTATTAATTTTAATTCATGCTTGCAAAATTGCATCTGCAAGAAAGATCACTACTGTA
ATACCCAATTTTCCATATGCAAGACAAGACAAGAAAGATAAATCCCGGGCGCCCATTACC
GCAAAGTTGGTTGCCAATTTATTGCAAACTGCTGGTGCTGATCATGTCATCACAATGGAT
CTCCATGCCTCCCAAATTCAAGGGTTTTTCCATATCCCGGTTGACAACCTATATGCAGAA
CCAAGTGTTTTAAATTATATTAGAACGAAAACAGATTTCGACAATGCTATTTTGGTGTCG
CCTGATGCAGGTGGTGCTAAGAGAGTAGCTGCTTTGGCTGACAAGTTAGATTTAAATTTT
GCTTTGATTCACAAAGAGAGGCAAAAAGCTAACGAGGTTTCAAAAATGGTGCTTGTTGGT
GATGTTACCAATAAATCATGTTTATTAGTTGATGATATGGCGGATACTTGTGGTACGTTG
GTAAAAGCTTGTGATACGTTGATGGAGCATGGTGCCAAAGAAGTTATAGCTATTGTTACA
CACGGTATTTTCTCCGGTTCAGCAAGAGAAAAGCTAAGAAATAGTAGATTGTCTAGAATT
GTTTGCACAAATACCGTTCCGGTAGATTTGGATTTACCTATTGCTGACCAGATCGATATT
AGTCCCACGTTCGCTGAAGCTATAAGAAGACTACACAATGGTGAATCCGTGTCATATTTG
TTCACCCATGCTCCAGTATAG
Promoter Sequence
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>PRS4 YBL068W
TACAGAAAAAACTAGTGATTGTAACGTCTGCAAATGGGCCCCAAGTTTTACAGGAGAAAT
TTCCTGATCTGGCTGATGAAATGATTTTCATCGATTACTTAACGTGTAGGGGTAAATCTA
GTAAACCACTAAGAAAAATGCTCGAAGAAAAGAAAATTTCTCAGTATGATCCGGTCGAGG
ATAAGGAAACTATACTTAACTATAATGAGGGGAAGTTCGATGTTGTACTCGATTTTGTCG
GTGGTTACGATATTTTGAGTCATTCTAGTTCATTGATTCACGGCGGTGGTGCGTACGTAA
CCACTGTAGGTGATTACGTTGCCAATTATAAAGAAGACATTTTCGATTCATGGGATAACC
CAAGTGCCAATGCAAGAAAAATGTTCGGGTCTATTATCTGGTCATATAACTACACACATT
ACTATTTTGATCCGAATGCAAAGACGGCTTCCGCCAATAATGATTGGATTGAGCAATGTG
GCGACTTTTTGAAGAACGGTACTGTAAAATGTGTCGTCGACAAAGTTTATGACTGGAAAG
ACCATAAAGAAGCATTTTCTTATATGGCCACTCAACGTGCCCAAGGAAAGTTAATCATGA
ACGTCGAAAAATTCTAGATACCCACTTACATTTACAATATGTTTTATTTTTAAACTTAAT
GAACTTCATAATTTAATGCTTAATATTTTCCCCCTCCCACCTTCTCCTGGCGTTCTCTGT
ACGTACATAACCATTTATTTTAATATATAATCAAATATTGTAACAATTGAAGCAGATGAG
TCTCGCTCCTTAGTTAAGCACGTGCCGATGATATCAATTGGATTTGTTAGCAAATCAGCC
TTGCTGCTCGATTCTCTGCTTTTTTTTTACTTCTCGGTCATTGAAAAATCCTGACGAAAA
TATTTCAAGGTCCTATATGGTCATCGACCTTGAGCATGTGGTAGACTACATAATGCACAT
AGACTCTCAGCTTCAACTCCACAAGGCTTCTCCAGCAAAA
Chr coordinates
Chr II from 92414-93394