Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
NPL4 Systematic Name
YBR170C Alias
HRD4 Strain
S288c Description
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>NPL4 YBR170C
ATGCTTATCAGATTTAGATCAAAAAACGGTACACACAGGGTTTCTTGTCAAGAAAACGAC
CTTTTCGGAACGGTCATTGAAAAGTTGGTGGGTAATCTGGACCCCAATGCCGATGTCGAC
ACATTTACTGTTTGTGAGAAGCCCGGTCAAGGTATTCATGCTGTTTCTGAACTAGCTGAT
CGAACAGTGATGGATCTAGGACTAAAGCACGGTGACATGCTGATCCTTAACTATTCGGAC
AAGCCCGCTAATGAGAAAGATGGTGTCAATGTTGAAATCGGATCCGTAGGTATTGACAGC
AAGGGAATTCGTCAACACAGGTACGGTCCACTAAGGATCAAAGAACTCGCTGTAGATGAG
GAACTAGAGAAAGAGGACGGATTAATTCCTCGTCAAAAATCAAAACTATGCAAGCACGGT
GATAGAGGTATGTGTGAATACTGCTCGCCTTTACCTCCTTGGGACAAAGAATATCATGAG
AAGAATAAGATCAAACATATATCGTTTCATTCATATCTTAAAAAGCTAAATGAAAATGCT
AATAAGAAGGAGAACGGCAGCTCTTATATTTCCCCTCTTTCAGAACCTGATTTTAGAATC
AATAAGCGTTGCCATAATGGCCATGAACCATGGCCTCGGGGGATATGTTCTAAATGTCAA
CCATCGGCAATTACATTACAACAGCAAGAATTTAGAATGGTTGACCACGTTGAATTTCAG
AAGAGTGAAATAATTAATGAATTTATTCAGGCGTGGAGGTACACGGGTATGCAAAGATTT
GGCTATATGTACGGATCTTATTCTAAGTATGATAACACACCTTTAGGTATAAAGGCCGTC
GTTGAGGCGATATACGAGCCCCCTCAGCATGATGAGCAAGACGGTTTAACCATGGACGTA
GAACAGGTCAAGAATGAAATGCTACAGATTGATAGACAGGCTCAAGAAATGGGGCTTTCG
CGAATTGGCCTAATATTTACAGATTTATCTGACGCGGGAGCTGGGGATGGGTCTGTTTTT
TGCAAAAGACATAAGGATTCGTTTTTTCTTTCATCATTAGAAGTTATTATGGCTGCTAGG
CATCAAACAAGGCATCCTAATGTAAGCAAGTATAGCGAACAAGGTTTTTTTTCTTCCAAG
TTTGTAACTTGCGTTATATCAGGTAATTTGGAAGGTGAAATTGATATTTCGAGCTACCAA
GTATCCACAGAAGCTGAAGCATTGGTTACTGCAGATATGATAAGTGGGTCCACATTTCCT
TCAATGGCATATATTAATGACACTACAGATGAAAGATATGTACCTGAGATATTTTACATG
AAGTCGAATGAATATGGTATAACAGTGAAGGAAAATGCGAAGCCTGCATTTCCGGTAGAC
TATCTTTTAGTGACGCTGACTCATGGGTTCCCGAATACCGATACGGAAACCAACTCGAAA
TTCGTTAGTTCCACCGGATTTCCATGGAGCAATCGACAAGCTATGGGGCAATCTCAAGAT
TATCAAGAATTAAAAAAGTATTTATTCAATGTGGCTTCAAGTGGAGATTTCAATCTTTTG
CATGAAAAAATCTCGAACTTTCATTTACTATTATACATAAATTCTCTGCAGATACTCTCT
CCAGACGAATGGAAGTTACTAATAGAATCTGCTGTGAAAAATGAATGGGAAGAATCTCTA
CTAAAACTTGTCTCATCGGCTGGTTGGCAAACGTTAGTCATGATCCTTCAGGAAAGCGGC
TAG Promoter Sequence
Download FASTA
>NPL4 YBR170C
TATACTTTATAACTATTTTTTAACGCAGATAATGACAAATTCTATACATATTTTTAAAAA
AACACTGAACGAGCGAATACATATCTTTGCACACAGTAGGCACTAATTGACTAATCTTCC
ATCATTATTTATTTTCAGCTCCCACTCTTTAATACACACTTCTTTCCGTTTCAAGATTGA
TTGATAACGTCTAGAGAGAGCTTGATTAAAGCAAATTTCTTTACAAACCATAACGAACAA
TTGAACCCAGCCCGGTTGCAATCTTTCAGCTTCTTGTAAAGTATCTTTAAATTCCAATTC
AATTAATTTAACTTCAGTTTCAAATCTCTTCCAGTAATCCTCCCCAATAGAGCCATTTTT
ATATAGAAGGTTTATCTGAGGAGCCAACTCTTTTAACTTTAATGATCGTCTAACAGATTC
TGCTCCTCTGTTCAATAAAGCGGCCTTCAACACCTTCTCGTGAATTTTTTCATTTTCACT
CATTTCCTTTATTTGGAAATACAGATCATGGGCATCGTTTTCGTCAAATATGGATGGTTG
CTCACTAATTTTTTTGGCCTGCTTCTTTCTGTAGCTTGAAGCAAACATCACAAGGGACAC
CACCAGAATAAAGACATATATGAGTGGGGTATAAACGGAGATTGATTTCGTCTCCACAAT
TGGCTCTTCCGTTTCAAAAAACGTCCCGTTGTTGGAGAATTTTGTTTCATTAAATTCGGA
CATATTGGCAAACTCAAGTAGTTGTGCGTACCTCTTTCCTGTACTTGAATTCGTTTAAAT
AAGCCATTTCATTAATATTTCATCAATTTTTTCACATATTATTTCAACTTTTAGACGTGT
TCCTAAAACTTTTGACGTTTTTTGGCGGGTAATAAGATGCGTCTACCCATTTTAAGGAAC
GCCCTCGTAACATACAGAACGAAGAGTGGCAAATAATAGGACAGTACTCTGAAGAAAAAT
TTCCCTATACTACTGATATCGATATACATTTAAGTGAAGT
Chr coordinates
Chr II from 578086-576344
