Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
TDP1 Systematic Name
YBR223C Strain
S288c Description
Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN) External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA View Seq
Sequence hidden Promoter Sequence
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>TDP1 YBR223C
ATGCAAATGTTGATTAAATTATGATTTCCTGAAACGGTTTTGATTAGAAGAGAAGAATCT
GATGCCGGTAAAGTGTTCCAGTCCCATTTTTTTCTAGAATGGAGTTTCTTGACAACGTTC
GAAGTTGCACCGTGTAGACCACCACCTCCCCGGCCATTGCCGACCATATTGGATACAATG
AATCGCGGTGCAGAAGGGTCTGGTGAGTAATTAGCTTTCACTTCGGAAGTCGGAGTTCCG
CTTCTATGACTATGTTTATTATTACTTGTATGATGATGATGTAGACCTATTTTGGAAAGC
TGAGCGGACTTCAGTTTGGATACTGAGGATGAGGCAGCGGAGTCAGATGATCGTCTTGAC
GAGTTTGAGAACAAGTCATCCGCCAGTCTAAAGTTTGGCAAATGTAAGGGCGAATCAAAG
GACGAGAGCTTATCTGAATGATGGCTTACTTGTGGTGAGTGTGATTCTACTGAACTACTT
GATTGCGTGGTTCCATTTCTACTCTCTTTTTCTTGTTTCCCCTTTTCTTTGTCAGCATTT
TTATGTTCAGTAATCATTGAACTTGTATGGTTATCATGTGCTTTTAAGTTGGAAATTTTG
TTACTGGTTATACTGGTTAACCCCCTATCATTCTTACTATCAATGTTTTTTGCTTCCTTA
TTGGAGCCCATTGTATTTACTTGAGCAGTTTATAAAAAGTGGATAAATGAGGGGAAAAAT
AATAAAAAAGAAAATTGAACAATCCTTCAATATGTGTCCTTTAATAATTACTACTACTTT
ACACACTTCTCCAGTAGCTGCTGCTTGTTTCAGGTGATGTGAACAACGTGTTTCAGCGTT
CTTGGTAAGTGTTGGTATGGATCCCTTCTGATGTATTTTCGGCGGCCGCACTAAACTGCG
AAAATGGTAATTTAATAAAGGGCTTATAAAGAGGAAAATAATGCAGAGAAACGGTGAGCC
CAGACAAGAATGATGATAATGTGTTTTCAACCGATCATTA
Chr coordinates
Chr II from 670297-668663
