Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
SIR2 Systematic Name
YDL042C Alias
MAR1 Strain
S288c Description
Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy External sources
Open in SGD
Open in KEGG
Gene Sequence
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>SIR2 YDL042C
ATGACCATCCCACATATGAAATACGCCGTATCAAAGACTAGCGAAAATAAGGTTTCAAAT
ACAGTAAGCCCCACACAAGATAAAGACGCGATCAGAAAACAACCCGATGACATTATAAAT
AATGATGAACCTTCACATAAGAAGATAAAAGTAGCACAGCCGGATTCCTTGAGGGAAACC
AACACAACAGATCCACTTGGGCACACTAAAGCTGCGCTCGGAGAAGTGGCATCGATGGAG
CTCAAACCAACTAATGACATGGATCCCTTGGCAGTGTCAGCAGCTTCAGTAGTGTCAATG
TCCAATGACGTTTTGAAACCAGAGACGCCCAAGGGGCCAATCATAATCAGTAAAAACCCA
TCAAATGGTATTTTCTATGGTCCCTCCTTCACTAAACGAGAGTCTCTCAATGCTCGAATG
TTTCTGAAATACTATGGTGCACACAAATTTTTAGACACTTACCTCCCCGAGGATTTGAAC
TCGTTATACATTTACTATCTTATCAAGTTGCTAGGCTTTGAAGTTAAAGATCAAGCGCTT
ATCGGCACCATCAACAGTATTGTCCATATCAACTCGCAAGAGCGTGTTCAAGATTTGGGA
AGTGCAATATCTGTCACAAATGTTGAAGACCCATTGGCAAAAAAGCAAACAGTTCGTCTA
ATCAAAGATTTGCAAAGAGCAATTAACAAAGTTCTATGTACAAGATTAAGATTATCCAAT
TTTTTCACTATTGATCATTTTATTCAAAAATTACATACCGCTAGAAAAATTTTGGTCCTG
ACTGGTGCAGGTGTTTCAACTTCATTAGGGATCCCGGACTTCAGATCTTCTGAGGGGTTC
TATTCAAAGATCAAACATTTGGGGCTCGATGATCCCCAAGACGTTTTCAATTACAATATA
TTTATGCACGACCCCTCTGTTTTCTATAATATTGCCAATATGGTTTTACCTCCAGAAAAA
ATTTATTCTCCATTGCATAGTTTCATTAAGATGCTACAAATGAAAGGGAAATTATTGAGA
AATTATACTCAAAACATTGATAATTTGGAATCTTATGCGGGAATAAGCACAGATAAACTG
GTGCAGTGCCATGGCTCTTTTGCTACTGCCACCTGCGTTACCTGCCATTGGAACCTACCC
GGTGAGAGGATATTTAATAAAATTAGAAACCTCGAACTTCCACTATGCCCGTACTGTTAC
AAAAAAAGAAGAGAATATTTCCCAGAGGGATATAATAATAAAGTAGGTGTTGCTGCATCA
CAGGGTTCAATGTCGGAAAGGCCTCCATATATCCTTAACTCATATGGCGTTCTCAAACCA
GATATCACATTCTTTGGCGAAGCACTGCCAAATAAATTTCATAAGAGCATTCGCGAAGAT
ATCTTAGAATGTGATTTGTTGATTTGCATTGGGACAAGTTTAAAAGTAGCGCCAGTGTCT
GAAATCGTAAACATGGTTCCTTCCCACGTTCCCCAAGTCCTGATTAATCGTGATCCCGTC
AAGCACGCAGAATTTGATTTATCTCTTTTGGGGTACTGTGATGACATTGCAGCTATGGTA
GCCCAAAAATGTGGCTGGACGATTCCGCATAAGAAATGGAACGATTTGAAGAACAAGAAC
TTTAAATGCCAAGAGAAGGATAAGGGCGTGTATGTCGTTACATCAGATGAACATCCCAAA
ACCCTCTAA Promoter Sequence
Download FASTA
>SIR2 YDL042C
AAGCCAAGAGTGTTGCTGCTTATCCGAGTGATCAAGATAACGATGTATTCGGCGAAAAGT
TGATTGAAACCTCCACTCCAATGGAGGACTTCGCTACCGAATTTTATAATAACTACTCCA
TGCAAGTCAGAGAAGACGAAAGGGATTATATTTTGGACTTTGAATTTAACTACAGAATTG
GAAAGTTAGCTTTGTGCTTTGCTTCTCTAAACAAATTCGCTAAGAGATTTGGCACCACGA
GCGGTTTATTTGGTAGTATGGCCATTGTTTTGTTACATGCCACAAGAAACGACACCCCCT
TTGATCCAATTTTGAAGAAAGTAGTCACGAAGAGCCTTGAAAAAGAGTATTCTGAAAATT
TCCCATTAAACGAAATATCTAACAATAGCTTCGATTGGCTGAATTTCTACCAAGAAAAAT
TCGGTAAGAATGATATAAATGGCCTGCTATTTCTGTATCGCTATCGCGATGATGTTCCGA
TCGGAAGCTCTAATTTGAAAGAAATGATTATTAGCAGTCTTTCTCCCTTGGAGCCTCACT
CCCAGAACGAAATTCTACAGTATTACTTGTAGCCTGCAACTCCTCAATGTGTCAATTAAC
TCTTACTTAATTTATGTATATATTTTTTATGTATATGCTTATATGCATGCGCATATGCTC
ATAAAAGATACATTGTTATAGGTCATTTCTTTTCCAAGCTACATCTAGCACTCCTTCCAA
CCATGGTCCAGGACAGCCAGGACCTTTTCTTGCCAAAATTCTTGCTTTCCCATCTCAGAG
AAAAAACGAGGAATTTTTCTTTGTCCTCTTTGGCCGCCAGTTGCGGTAAAATATTTTTTT
TCTAGGTCGCATAGTTTGAAAGACTTGTCTTTTTCACCACCCAAGAAAAATATATTTAGT
GAAGAGATGTAAAGCCCATTCTCACGTATTTCAAGAAATTAGGCATCGCTTCGGTAGACA
CATTCAAACCATTTTTCCCTCATCGGCACATTAAAGCTGG
Chr coordinates
Chr IV from 378445-376757
