Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
HEM12
Systematic Name
YDR047W
Alias
HEM6
Strain
S288c
Description
Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>HEM12 YDR047W
ATGGGTAACTTTCCAGCTCCAAAAAACGATTTGATATTGAGAGCCGCAAAGGGTGAAAAA
GTCGAGAGACCGCCATGCTGGATAATGCGCCAGGCAGGTCGTTACCTGCCGGAATATCAC
GAGGTGAAAAACAATCGTGATTTCTTTCAAACTTGCAGGGATGCGGAAATTGCTTCTGAG
ATTACTATCCAGCCGGTAAGACGCTATAGAGGCCTCATTGATGCTGCTATTATTTTTAGT
GATATCTTAGTTATTCCGCAAGCCATGGGTATGAGGGTCGAGATGCTCGAAGGTAAAGGT
CCACATTTCCCAGAACCTTTAAGAAATCCGGAAGACCTCCAAACGGTATTAGACTACAAG
GTTGATGTTTTGAAAGAGTTAGATTGGGCTTTCAAGGCAATCACCATGACAAGGATCAAG
TTGGATGGTGAGGTTCCCTTATTTGGCTTTTGCGGGGGACCTTGGACTCTAATGGTTTAT
ATGACGGAAGGCGGTGGATCCCGTCTTTTCAGATTTGCCAAACAATGGATTAACATGTAT
CCAGAGCTTTCTCACAAATTATTACAAAAAATCACTGATGTGGCCGTGGAGTTTCTGAGT
CAGCAAGTCGTGGCGGGTGCTCAAATACTACAAGTTTTTGAAAGTTGGGGTGGTGAGCTT
TCGTCTGTAGATTTTGATGAGTTTTCCCTACCATATTTAAGACAAATTGCCGAAAGAGTG
CCTAAAAGATTGCAAGAATTAGGTATCATGGAACAGATTCCTATGATCGTTTTTGCGAAA
GGGTCGTGGTATGCTTTGGACAAGCTATGCTGTTCAGGATTTGACGTTGTTTCGTTGGAC
TGGTCCTGGGACCCAAGAGAAGCGGTAAAAATAAACAAGAACCGTGTCACCTTGCAGGGC
AACCTGGATCCTGGCGTCATGTATGGTTCTAAAGAGGTAATAACAAAGAAAGTTAAACAG
ATGATTGAGGCTTTTGGAGGTGGGAAGTCCCGCTACATTGTTAATTTCGGTCACGGTACC
CACCCTTTCATGGATCCAGACGTCATCAAGTTTTTCTTGGAGGAGTGCCACAGAATTGGT
TCGAAGTAA
Promoter Sequence
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>HEM12 YDR047W
AAATGACCGCATATTTTACTGTCATGCTTCTGTCAAGAAAAACGAGCCTTGGATGAGAGC
TTTCGTTGATCGCGGCTCGAAGTTCAGGTAGAGAAATATAGCAGAGCTCTTTTCGCGGAG
CCGCATGCACGGCTACATTAAAAGGTGTCCTTCCAGCTCAGCGATATGTGTCGGCCGGAA
AAAAAAAGCACGCATCCGGCAAGCACACTAGTAAGTCTAATGCAGGATGAAGAAACGAAG
AAGGTGCCATGAGAAGGAAAATAAAACTCAATGGGACGGAACGGCAGCATTTTTTAACAA
ATTATTTTGGATTCATCCGTAACAATATAACTTGGTACGGGAACGGCATGTTTTAAATGC
ACAGCGGTGCCTTGTTTCGCCGTGGATTGTTAAAGGCTCTTTTTCGGACGCCACATATTC
CTATGCTGCACCAGCAATTGGTGTCTTCGGATCATACTACTTCGCACTAGTTTATATTCA
AGGCTTTTAATGGAGCTTCGCTCTTAAAAGAAAAAACTTCTTTACTTCCATGCGCGCGTT
TTTGGCGTACGTAGCACTGCGAAAGAGTGGGTGATATATAGAGAACATGTTGTAGTATAC
GTACGCGGGCAATTGTGGTGACAGTATCTCTTTCTGTTAGCAAGTAATATATCCTTGGCC
TCAACCTGTCAATAGTGTTAGTTTATCCGCCATCTTGGCGCTATCATACACGATCTTTTT
CAATGTTTCTCGTATATACAGGACAGGGTTCGGGGTTTTTGGCGGCAGGAGAGGAAAGCA
AAAAAAAATGAGGCAAGAGTTTTAATTTTGCCAGCGAAATGTTCTGCCATTTTCATCTTT
ACCGCTCGAATTAGTGATGTTCCAGACGAAGGTAACATAGAGTGATCGATAGGTTCTTCA
ATTCATCAAGCATTATCTCAGAATTGTGTTTGGTAAGCTCTCTTCGAGAAAAGGAAGAAC
AAAAAAAAAAAAAATAAAGCAAAGAACAGGTTATAACGCT
Chr coordinates
Chr IV from 551860-552948