Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name STE5
Systematic Name YDR103W
Alias HMD3, NUL3
Strain S288c
Description Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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>STE5 YDR103W
ATGATGGAAACTCCTACAGACAATATAGTTTCCCCTTTTCACAATTTTGGTAGCTCGACA
CAATATAGTGGTACCTTGTCGAGAACTCCCAACCAAATAATAGAGCTAGAGAAGCCCAGT
ACTCTATCCCCATTGTCAAGAGGAAAAAAATGGACGGAAAAGTTAGCCAGGTTCCAAAGA
AGTAGTGCTAAAAAGAAAAGATTCTCACCTTCTCCTATTTCCTCCTCTACATTTTCGTTC
TCACCCAAATCTAGGGTCACTTCTTCAAACTCTTCTGGCAATGAAGACGGTAACCTAATG
AATACACCTTCTACGGTTTCCACTGATTATTTGCCACAACACCCTCACAGAACATCGTCT
TTGCCAAGACCTAATTCCAATCTCTTTCACGCAAGTAATAGTAACCTATCCCGAGCAAAT
GAGCCCCCAAGGGCCGAAAATTTATCAGATAATATACCACCCAAGGTCGCTCCATTTGGC
TATCCAATACAAAGAACCTCTATTAAAAAATCCTTTTTGAATGCTTCTTGTACGTTATGT
GACGAGCCTATTTCTAACAGAAGAAAGGGAGAGAAAATTATAGAGCTTGCATGTGGCCAC
TTAAGTCACCAAGAATGTCTTATTATCTCTTTTGGCACCACTTCAAAGGCAGACGTTCGT
GCGCTATTTCCTTTTTGTACCAAATGTAAAAAAGATACTAACAAAGCCGTTCAATGCATT
CCAGAAAATGATGAACTAAAGGATATTCTAATTTCTGATTTTTTGATTCATAAGATTCCT
GATTCTGAGTTATCAATCACACCTCAGTCCCGCTTTCCTCCTTATTCACCACTCTTGCCT
CCTTTTGGGTTATCCTATACACCTGTTGAAAGACAAACGATATATTCTCAAGCTCCAAGT
CTAAACCCAAATCTCATATTGGCTGCACCCCCCAAGGAAAGAAACCAAATTCCACAAAAA
AAATCAAACTATACATTTTTACATTCACCCCTGGGGCACAGAAGAATTCCGTCCGGAGCA
AACTCTATCTTAGCAGACACCTCTGTAGCGTTGTCAGCTAATGATTCTATTTCTGCTGTT
TCCAATTCGGTAAGAGCAAAGGATGACGAAACCAAAACAACGTTGCCGCTGTTAAGGTCA
TATTTTATTCAAATTCTTTTGAACAATTTCCAGGAAGAATTGCAGGATTGGAGAATAGAC
GGGGACTATGGATTACTAAGGTTGGTAGACAAATTGATGATTTCCAAAGATGGTCAGAGA
TATATACAATGCTGGTGTTTCTTATTTGAAGACGCATTTGTAATAGCAGAAGTGGATAAC
GATGTTGATGTTTTGGAAATTAGACTAAAGAATTTAGAAGTATTTACACCTATTGCCAAC
TTGAGAATGACTACACTCGAAGCTTCAGTACTCAAATGCACCTTAAATAAACAACATTGC
GCCGATTTATCAGATCTTTACATTGTTCAGAATATAAATTCTGACGAAAGCACAACTGTA
CAGAAATGGATATCAGGTATATTGAATCAGGATTTTGTATTCAATGAGGACAATATCACT
TCGACCCTGCCTATTCTTCCCATTATAAAGAACTTTTCAAAAGATGTTGGTAATGGTAGG
CACGAGACGAGTACCTTTCTAGGTTTAATCAATCCTAACAAAGTTGTTGAAGTTGGAAAT
GTGCACGATAATGATACTGTAATCATAAGGAGGGGATTCACCTTAAATTCAGGAGAATGT
TCTAGGCAGAGTACTGTCGACAGTATACAATCTGTTCTAACCACGATAAGCTCAATTCTT
TCCCTTAAACGAGAAAAACCTGATAATTTGGCAATAATCTTACAGATCGATTTTACGAAA
TTGAAGGAAGAAGACAGTTTAATTGTTGTTTATAACAGTCTAAAAGCTTTAACCATTAAA
TTTGCGCGTTTGCAGTTTTGTTTCGTTGATCGAAATAATTATGTTCTGGACTATGGATCG
GTATTACACAAGATAGATTCACTAGATTCCATCTCAAATCTCAAATCAAAGAGTTCCTCG
ACACAATTTTCACCTATTTGGTTGAAAAATACTCTATATCCCGAAAATATTCATGAACAT
TTGGGTATTGTTGCTGTATCAAATAGTAATATGGAAGCAAAAAAATCCATACTATTTCAA
GATTACAGATGCTTTACAAGTTTTGGAAGAAGAAGGCCCAATGAATTGAAGATTAAGGTG
GGCTATTTGAACGTTGACTACAGTGATAAAATTGATGAACTAGTCGAGGCCAGCTCCTGG
ACTTTTGTTTTAGAAACTCTTTGCTACAGTTTCGGTCTAAGTTTTGATGAACATGATGAC
GATGACGAAGAGGATAATGATGATTCGACCGATAATGAACTTGATAATAGTTCAGGATCA
CTGTCGGATGCTGAATCTACAACTACTATTCATATTGATTCTCCATTTGATAATGAAAAT
GCTACCGCAAATATGGTGAATGACAGAAACCTTCTCACTGAGGGTGAACATAGCAATATA
GAAAACTTAGAAACTGTCGCTTCTTCAGTACAGCCAGCTCTGATTCCTAATATTAGATTT
TCACTTCATTCTGAGGAGGAAGGTACTAATGAAAATGAAAATGAAAATGATATGCCAGTA
TTATTACTTAGTGATATGGATAAAGGAATCGATGGCATAACCAGACGCAGTTCATTCTCG
AGTCTTATAGAGAGCGGTAATAACAACTGTCCCCTCCATATGGATTATATATAG
Promoter Sequence
Download FASTA
>STE5 YDR103W
TCAAAGCAGTTTGTGCGATTTGTCCAGCAGTTCTGTATTTGTTCAAGACCGATTCCTGTA
GAATATTTTTGTCCTTTAGCAAAATCTGAGTATCCTCGTGGGAGATAGCTAGAGCCATGA
TAGTTTTAGCAATATTAGTCGGGTCGGGTTTTTTCTTAAAAGTATTTTGAATAACACGAT
GCTTTAGCTCATCTCATCTCTTCTGCTGAAATTTTTCTTTACTTCGGTAAAATTTTTTCA
GAAAGCAAAAAAAGCTTCACAGAGGCATGACCCTCTCCGGGTAAAAAAAAGCTTAGGGTT
ACCGGCCTGTCATTTTTAGGGCATTATCAATTTTTTGCCATCTAGTTGCAACTATAATAA
TACAGTATGAATTGCACGAAAGAGCAGTCAATGTAAATTCACGAAGTGACTGACAGAATA
CTGACATCAGCTGATTTCTCATAGAGCTGTTTCTCTGATAACACGTTGTTTGAACATCGA
CAAGATGAAAATCTAGAAGTATCAAGTTTCCTTTAAAGGGATATATAACAGATTCTAAAA
CTGACAGAAATATTTCGAGTGAAGAAGAAGCGTTAAATATTGGATCTTTCCGCAGTTCTA
CTCTGATACATTTTTGAAGTAGGAGAGTCATTTAGAAGGCGTATTGCTCAATAGTAGAAA
GCAGGCCTGTGCACATGAATTAATTAAAAAATATAAAGGTAGTGATTAGACGACACATGT
CCATAGGTAACCTGTCATAATTTTGAACAATTTCCCTTCTTTTCTTTTTTTTTTTTGGGT
GCGGCGATATGTAGCTTGTTAATTTACACATCATGTACTTTTCTGCATCAAAATATGAAA
GGCGATAGTAGCTAAAGAAAATACCGAGAATTTCCTCGAAAAGTTGACGACAAAAGAAAG
GCATAAAAAAGTAATTTGAAAATATTTTAAAACTGTTTTAACCCATCTAGCATCCGCGCT
AAAAAAGGAAGATACAGGATACAGCGGAAACAACTTTTAA
Chr coordinates Chr IV from 658350-661103
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