Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name MMS21
Systematic Name YEL019C
Alias NSE2, PSO10
Strain S288c
Description Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function
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Gene Sequence
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Promoter Sequence
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>MMS21 YEL019C
TGCTCTTCTCATGAACTGCACCGTATCATCCAATTCAAACTGCACTTGTCTAGCCAATTT
CCAGTCGTCCGTACCAATGACCTTTCGCATTACACCGTCCGTTATGCTCTTTTGAAGAAT
CAGCTGCAGTTCATGAACGCTGCCGGGCGTTTCGTTCTTTATGTCTTCGTAATTTATCTC
ATTCTTGATAATGCTACCATCGGGACTCTTGAATAGCTTCTGAAAATTCCCAGTTTTACT
TTCCAATTTATTCAGAACGGTATCTCTGTATAATTTCAATAGTTTTTCTCTTTTTGGGTC
CATTGAATGCGCCATGTGTGGCGTAGTCGTAGTTATAGTAGCACTGGTACCAGCAGATCC
ACTTTTGCCAGCATTTGCATGTGGTTGCAGTTGCGATGCACCGGTCTTTATACCGTTCTT
CAATATCTCATCCTCCATCATCCTTATTTGTTCGACCTGCGTTTTCTTGAATCGATCGTA
CTTTTCGTCAAGGAGCTTCTCGATATCATGCATTTCCAAACCGTGTAGACTAAGTTGTCC
ATCGTTTAGTGTTGTTCTGTACTCTGGGAATAAATTCTTAACTATGGTCAGGATATCGTT
GATGCCCAGTTTCCTGTTTCCATTTGCCACGTTGCTTTGCCTTCTTAAATTTGTCAGCTC
GTTGATTAGCAAATTGTTTTGTATTTCGTTAGTCAACTTGACTAGCGATATTCGAAGATT
ATTCCCAATCATGTTGATTCCTCCCCCGTTCCTAACCAGTTCTTCATTCTTGTTGGAAAT
TAAAGTGTGTATTAGCTGCAACACTACCAATTCACTTACCTCTTTATCCATCTATGCGTT
CCTTTGATTCTGGTTACTCCGGCACGCAGAAGTATCTTTTTACCAGTGCTTCTCTGGTTA
TTTTCTTCCTCTTTTCCTGTGTAGAAAAAAACTTGCTAAAATAATCGTGTCAGTTAAAGA
AACCAAGGCAAGACTATATAAAAAAAGAATAACTTTAAAA
Chr coordinates Chr V from 121301-120498
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