Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
DLD3
Systematic Name
YEL071W
Strain
S288c
Description
2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>DLD3 YEL071W
ATGACGGCCGCACATCCTGTTGCTCAGTTAACTGCCGAGGCATACCCTAAAGTCAAGAGA
AACCCAAATTTCAAAGTTCTCGACTCGGAAGATTTGGCGTACTTTCGTTCGATTTTGTCA
AATGATGAAATCTTAAACTCTCAAGCTCCAGAAGAGCTTGCTTCGTTTAACCAGGACTGG
ATGAAAAAATATAGAGGCCAGTCCAATTTAATTCTCTTGCCAAACTCCACTGATAAAGTG
TCCAAGATTATGAAATACTGTAACGATAAAAAGTTGGCAGTAGTACCACAAGGTGGTAAC
ACCGACTTGGTCGGAGCCTCTGTTCCGGTATTTGATGAGATTGTTCTTTCTCTAAGAAAT
ATGAACAAAGTCAGAGATTTTGATCCAGTTAGCGGGACTTTCAAGTGTGACGCGGGTGTC
GTTATGCGTGATGCGCATCAATTTTTACACGACCATGACCATATCTTCCCATTGGATCTG
CCTTCTAGAAACAACTGTCAAGTGGGCGGTGTAGTTTCAACAAATGCAGGTGGTTTGAAC
TTTTTAAGATATGGGTCTCTACACGGTAATGTTTTGGGTTTGGAAGTGGTGCTACCCAAC
GGTGAGATTATCAGCAATATCAATGCCCTAAGGAAGGACAATACTGGTTATGACTTGAAA
CAATTATTCATCGGTGCAGAGGGTACTATCGGTGTCGTTACTGGTGTATCCATAGTTGCA
GCAGCAAAGCCAAAAGCCTTGAATGCCGTATTTTTTGGTATTGAGAATTTCGATACCGTT
CAGAAATTATTTGTCAAGGCTAAAAGTGAATTATCTGAGATTTTATCTGCTTTTGAATTC
ATGGACCGTGGCTCCATTGAATGTACGATAGAATACTTGAAGGACTTGCCTTTCCCTCTG
GAGAACCAACACAACTTTTATGTTCTTATTGAAACGTCAGGGTCCAATAAGAGACACGAC
GATGAGAAGCTGACTGCTTTCCTCAAAGATACCACAGATTCTAAATTAATTTCGGAGGGT
ATGATGGCTAAGGACAAAGCCGATTTTGATAGACTTTGGACCTGGAGAAAATCTGTTCCA
ACAGCTTGTAATTCTTACGGTGGTATGTACAAGTATGACATGTCACTTCAATTGAAAGAT
TTATATTCCGTATCTGCGGCTGTGACGGAGAGATTAAACGCAGCCGGTTTGATTGGTGAT
GCACCAAAACCAGTTGTTAAATCATGTGGTTATGGTCATGTCGGTGACGGAAACATCCAT
TTAAATATCGCGGTAAGAGAATTTACAAAACAGATTGAGGACTTACTAGAACCATTTGTT
TATGAATATATTGCATCAAAGAAAGGTTCCATCAGTGCTGAGCATGGGATCGGTTTCCAT
AAGAAAGGTAAGTTACACTACACCAGAAGTGATATTGAAATTAGATTTATGAAGGATATC
AAAAATCACTACGATCCAAATGGAATCTTAAACCCATACAAGTACATTTGA
Promoter Sequence
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>DLD3 YEL071W
CTTTAAAGTGCTATGTAAAGTACCTAAAAAACTTGTTATAGAAGTCTCATTCGAAAGCAT
GTGGGCTCAAAAATTGTGAATAAGATACATAGAAGGAGCCGCTGATCGACACATAATAGT
AGAGTTGAACCTAGTTGGTTCAACCATTATCATAGTTATACGAATAAAGCCACAATATAA
ATGGCCAACCGCTGTTGTCAAACAAGACTATAGGTTCATTTTAACCTGGCGTGCAGTACG
CTGGTCTTGCTAACGCCTCTACAATACGTACAGTGCAGGTTTTGACGAATGAAAGTGGTT
AGAAGATTAATGTGATAGAAACAAGAATTTTCTCGCAAAGATCTGTATGAAAGGAAACGT
TTGGTAAGAACTCTGCGATCCAAATTCTACTGAATGAATAGAAGGCTTCTACAGAACAAG
TTGTATCGAAATGATTGTTGGCGACTACTATATTTCTATAGGCATGAAAGTTACTCATAA
ACAGGAAAGACGCATTTTAGTAGCTTGACCTGGTCAGATTAATCAGCTTCCAACGTTACT
TCCCTTTCGCAAGAATCTACCCAAAATGTCTCGAGCATCTTGATAATTACAGTATCGTTC
GTCCCGACTTGGCATTTGTTTAAATTTCTAAGATGCTTCCTATAGGAACATAATTGTCAA
GAAAGCACAACAAATTGTCTGCAATGTCAACAGGAGTGGCGCATTTTATGTTTTTTCATT
TTTTTTTTTTTGTGCGTGATCATTAAGCGGGATATTGTCCACAGTCATCTAAAAGAATGA
CCATTTCGACGACTTAGTTCGGAAAATATTTCCAGCGGATGACACCACTTGCCACAGTTG
GTGACCGCCAAATCTAAGTCACGCGCGGAAACTGAAAGGTTGTGAGTATATAAGTGATCA
CTCGCTTATATAACTGACGAGGCAGAACAGGGTGCCAAAATGCTCCTCAATATTTTATTC
ATTTGAGATTCAAGGCTTAAAGACAGCATATATAAGAATT
Chr coordinates
Chr V from 16355-17845