Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
ISC1 Systematic Name
YER019W Strain
S288c Description
Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2 External sources
Open in SGD
Open in KEGG
Gene Sequence
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>ISC1 YER019W
ATGTACAACAGAAAAGACAGAGATGTTCACGAGAGGAAGGAAGATGGTCAATCTGAGTTT
GAAGCACTGAACGGGACCAACGCAATTATGTCCGATAATAGTAAAGCGTATTCCATAAAG
TTTCTGACCTTCAATACATGGGGGTTAAAATACGTCTCCAAACACCGTAAAGAAAGACTC
AGAGCAATTGCTGATAAATTGGCGGGCCACTCAATGCTTACGCCAATATCTGACGAGTTG
TTGCCCAATGGTGGAGATAGTAATGAAAACGAAGATTACGACGTGATTGCCTTACAAGAA
ATCTGGTGTGTGGAAGACTGGAAGTATCTAGCTTCTGCGTGTGCCTCCAAGTATCCGTAT
CAGCGTTTGTTCCATTCTGGTATTCTGACGGGGCCTGGGTTGGCCATACTGTCCAAGGTC
CCGATAGAGTCGACCTTTCTTTACCGGTTCCCGATAAACGGTAGACCGAGTGCGGTGTTC
CGTGGCGACTGGTACGTAGGGAAATCTATAGCAATCACCGTATTGAACACAGGAACCCGC
CCCATTGCAATAATGAACAGTCACATGCACGCCCCATACGCCAAGCAGGGTGATGCCGCC
TACTTGTGCCACAGATCTTGTCAGGCCTGGGATTTCAGCAGGCTCATTAAGCTTTACAGG
CAGGCCGGTTATGCGGTGATTGTGGTGGGTGACTTAAACTCCAGACCGGGCTCACTGCCC
CACAAATTTCTCACGCAGGAGGCCGGCCTGGTCGACTCCTGGGAGCAATTGCATGGGAAG
CAAGACTTGGCGGTGATCGCTCGTCTGTCTCCATTGCAACAATTGCTTAAGGGCTGTACC
ACGTGCGATTCGCTGCTCAACACATGGAGGGCCCAAAGACAACCCGATGAGGCATGCAGG
TTGGATTATGCTCTTATCGACCCTGATTTCTTGCAAACAGTAGACGCAGGTGTCAGGTTC
ACTGAACGGATCCCTCACCTGGACTGCAGTGTCTCTGACCATTTTGCATACTCATGCACC
CTTAACATCGTCCCACAGGGCACAGAGTCCCGTCCATCCACCTCCGTTAAGCGTGCGAAG
ACTCATGATAGAGAGCTGATCTTGCAGAGATACTCCAACTACGAAACCATGATAGAATGC
ATCCACACGTACTTGAAGACAGCCCAAAGACAGAAATTTTTCCGTGGCCTACATTTCTGG
GCCTCAATACTTCTCCTAATAGCGTCGTTGGTCGTGACAACGTTTACTGCAAACAAGGCA
GGCTGGTCCTCCATCTTCTGGGTCCTTTTCGCTATTGCTGTCTCCATCTCGGGCACCATC
GACGGTGCCATCTCCTTCTTGTTTGGCAGGTCTGAAATCAGAGCCCTCATCGAAGTCGAA
CAAGAGGTTCTGGACGCGGAGCACCACCTGCAAACTTTCTTGAGCGAGAAATGA Promoter Sequence
Download FASTA
>ISC1 YER019W
ATATTATAAAATAAGTGGATGATGCCTTTATTTGAAGACTGCGTTAATCTCCTTTAATAT
AGAATGGGTCCTTGTAAAAGTTATGTATAGACAGTAAGAACCAATTTATTCCTCATCTAA
ATCATAGGCCCAGAATAAACTGAACAGATGCGTATAAAGGCGTTATAAAGATGCCAGAAG
CATATCGCGGGCCACGACTAAAAATGCCGCGAGGTCGCCCTGGACGGTAAGCACGTGCTC
AAGTGTTGCCCGACTCTTGGGGTCCAGCGCCGGGTGAGAGTTTCCGATCACGTGGTCTCC
GTGCATCGCGACTTCGATCCAGCAGCGTGAATCATCGCCGAATACGAAACGTACGTCATG
CACATCGCTGGCTCCGGGTAGTACACGAAGCTGCAACAGCCGTTCGTACAGTGCGACCTC
TGCGGCATCGTTACCCGACTGCGCAGCCCAACGTGCGCGTAATTGGACACACTCTTTACC
ACGCTGTTGCAGCAGCGAGTCCAGCTCGCGCGATTGGGCTGCTAAGGTCGACTGCCGTCT
AGATAACTCAGATTCACGCTCGTGATAGCTTCTCCACTGCTCTCTGGTGGTATTTGTAGC
TTGTTGGGCCGCATGTATTTGTTGCTGCAGAGCGGTGCGCTGGGTGGCAAGCCGTTGCAG
TTCATCTATGAGATGTTGGTGTTGGTTATGTAATTGACGCATTTCCGCTTGGAACTGTTG
CAGCTGTTGGCGCGCGTGGTTTTGCTGACGTGCCAGTACCTGGGCCACGTCCTTTTGGAA
CCCGTCCATCCGGCGCTCAAGGTCCGAAAATGCGTCTATGCTGGCCATTCTTGTATGTGT
GTATGTGTTGTATACGTATGAGCGGTTTTAATTGAATCGGCTTAGCCTGTTTTTGTTTTT
GTTTTTGTTTTGTTTTGGTTTGGTTTGATTTATTTTGGTTTGGCTTAAATCTTCGAGGAA
ATTTGCGCTTTCCGCGTAAAAAGGGAAAAAAAGCAGATAT
Chr coordinates
Chr V from 192797-194230
