Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
RNR1
Systematic Name
YER070W
Alias
CRT7, RIR1, SDS12
Strain
S288c
Description
Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>RNR1 YER070W
ATGTACGTTTATAAAAGAGACGGTCGTAAAGAACCTGTCCAATTCGATAAGATTACCGCT
CGTATATCACGCTTATGCTATGGTTTAGATCCAAAACATATCGACGCCGTTAAGGTCACC
CAACGTATCATTTCTGGTGTCTATGAAGGTGTCACAACAATCGAACTAGACAACTTAGCC
GCTGAAACATGCGCTTATATGACTACTGTTCATCCAGATTACGCCACCCTAGCGGCCAGA
ATTGCCATTTCTAATTTACATAAACAAACCACAAAACAATTTTCTAAGGTTGTCGAAGAT
CTTTATAGATACGTCAATGCTGCTACTGGTAAGCCCGCTCCCATGATCTCTGATGATGTC
TACAATATTGTCATGGAAAACAAGGATAAATTGAACTCCGCAATTGTCTATGACAGAGAT
TTTCAGTACAGTTATTTTGGTTTTAAAACTTTGGAACGTTCTTATTTACTAAGAATCAAC
GGTCAAGTGGCCGAACGTCCACAACATTTAATTATGAGAGTCGCACTAGGCATCCACGGT
AGAGATATCGAGGCTGCTTTAGAAACGTATAACTTGATGTCTCTAAAATATTTTACTCAC
GCCTCTCCAACGTTGTTCAATGCCGGTACTCCAAAACCTCAAATGTCCTCTTGTTTCTTG
GTTGCCATGAAGGAGGACTCTATCGAGGGGATTTACGACACCTTGAAGGAATGTGCTTTG
ATTTCCAAAACTGCTGGTGGTATTGGTCTACATATCCATAACATTCGTTCAACTGGTTCT
TACATTGCTGGTACAAACGGTACTTCTAACGGTTTAATTCCTATGATTCGTGTTTTCAAT
AACACTGCCCGTTATGTTGACCAGGGTGGTAATAAAAGACCTGGTGCGTTTGCCCTTTAC
CTGGAACCATGGCATGCTGATATATTTGATTTTATTGATATTAGGAAGAACCACGGTAAA
GAGGAAATTCGTGCAAGAGATTTGTTCCCTGCTCTATGGATTCCTGATCTTTTCATGAAG
CGTGTCGAAGAAAATGGGACCTGGACATTATTCTCTCCAACATCAGCTCCTGGTTTAAGC
GATTGTTACGGTGACGAGTTTGAGGCTCTATATACCCGCTACGAGAAAGAAGGTCGTGGT
AAGACTATCAAAGCCCAAAAATTATGGTATTCCATTTTGGAAGCTCAAACTGAAACTGGT
ACACCTTTCGTTGTTTACAAGGATGCTTGTAACAGAAAATCTAATCAAAAAAACTTAGGT
GTCATCAAGTCATCAAACTTATGCTGTGAAATTGTTGAATACTCAGCTCCAGATGAAACT
GCTGTTTGTAACTTGGCTTCCGTTGCCTTACCAGCATTCATTGAAACTTCTGAGGATGGT
AAGACTTCCACATACAACTTCAAAAAATTACATGAAATTGCTAAAGTTGTTACTCGTAAT
TTAAACAGAGTCATTGATCGTAATTACTACCCTGTTGAAGAAGCGAGAAAATCCAATATG
AGACATAGACCAATTGCTTTGGGTGTTCAAGGTCTCGCTGACACTTTCATGCTGTTACGT
TTGCCATTTGATTCTGAGGAAGCCCGTTTGCTAAATATCCAAATCTTTGAAACTATTTAT
CATGCCTCCATGGAAGCTTCTTGTGAACTAGCTCAGAAGGACGGTCCATACGAAACTTTC
CAAGGATCTCCTGCTTCTCAAGGTATACTACAGTTTGATATGTGGGACCAAAAACCCTAC
GGCATGTGGGATTGGGACACCTTAAGAAAAGATATCATGAAGCATGGTGTTAGAAATTCC
TTGACCATGGCACCAATGCCTACTGCATCCACATCCCAAATATTGGGTTATAATGAATGT
TTCGAACCAGTCACTTCCAATATGTACTCCCGTCGTGTCTTATCCGGTGAATTCCAGGTT
GTGAACCCTTACTTACTGCGTGACTTGGTTGATTTAGGTATTTGGGATGAGGGTATGAAA
CAGTATCTGATTACACAAAATGGCTCCATTCAAGGCTTACCAAACGTTCCACAAGAATTG
AAGGACTTATACAAGACTGTTTGGGAAATTTCACAAAAGACTATCATTAACATGGCAGCC
GATCGTTCTGTCTATATTGATCAATCTCATTCTTTGAATTTGTTCTTACGTGCCCCAACT
ATGGGTAAACTAACAAGTATGCATTTTTACGGATGGAAGAAGGGATTGAAGACCGGTATG
TACTATTTGAGAACCCAAGCTGCATCTGCTGCAATTCAATTTACTATTGATCAGAAGATT
GCGGATCAAGCTACAGAAAACGTTGCTGATATTTCCAACTTGAAGCGTCCATCATATATG
CCTTCCAGTGCAAGCTACGCTGCCAGCGATTTCGTGCCCGCAGCTGTGACTGCAAACGCA
ACTATTCCATCTCTAGATAGCTCCTCGGAAGCTTCAAGAGAGGCATCTCCAGCTCCAACA
GGTAGCCACTCATTAACTAAAGGAATGGCAGAATTAAACGTTCAAGAGTCTAAGGTAGAA
GTTCCTGAAGTACCTGCCCCAACTAAGAATGAAGAAAAAGCTGCCCCCATCGTTGATGAT
GAGGAAACCGAGTTCGACATTTACAACTCTAAGGTTATAGCATGTGCTATTGATAACCCA
GAAGCTTGTGAAATGTGTTCGGGTTAA
Promoter Sequence
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>RNR1 YER070W
GGGTTATGGAGAGTATGCTGGTATCCCTGAAAATAAAATTATTGGTGTCTGATCACTGTG
TATAGTAGATCTGCAGCTCAGTCACATGAGACATTAACGTATATAAATATATAAATATAT
ATATATCCATTAAATAACGAAGTAGGACATGGTCTAAAAATAGTGCTTCTCATGTATTGA
TTTTGAGTAGCCATAAGAATAATTATTGATTTCAAGATCTTTGATCTCCTTACATCCAAA
ATTATAATACCACTTTATGGTATCACGACATCACCACAACAGAGAAGGATTGCCGCATTT
GGATATCGTAAACAAAGGCGTTACCATAGAAATGTACTGATTGGCAGAATTACTCTTCAG
GAGAATCTTTCATACAAAGGAATTCCATTGGGGAAAATCTCGTTACCAAGTCAATGCTGA
ACTTTCTATGGCCTTTGTTTACTATCGTTAATTATTTTACGACCACTTCTGGGTAGAAAT
ATTTCGTAGCCCTGGAACGAGCTTGTTTACGCGTTTTATCCCATTATATGGCACCCAAAT
CAAATTTAAAAAGAAAAAACGCGTAAACAGTGTCGGGTAAGTTCATCCTCTGTTACTTTA
ATTGCTTCTTTTTTTGAAATTCTAAGTAAACGCGTCATTTTGATCCTCAGGACACAGAAA
TCCTTGCAGAATCTTATTGGGTGTTGAATAGAGGACGCGTAAAAACGATATGGAAATTTT
TTTCATATAGTGTAGAAAGAATAGGTTGGCGTAGGTAGTTTCGTGTTTGATAGAAACCTC
CAACAAAGTCTGCAGCTCACGTTTTAGAATAACAAGTTTAGAGTTTATCTTGTTGCCTTT
GTTAAGTCAGTACCATTGAATAAAAATTATATAAAGGAGCTAATATTTCATTGTTGGAAA
ATTACTCTACCATAATTGAAGCATATCTCATCCTTTTCATCCTTTTCAACGCAAGAGAGA
CACCAACGAACAACACTTTATTTGTTGATATATTAACATC
Chr coordinates
Chr V from 298950-301616