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Locus Information
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| Standard Name |
RSP5 |
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| Systematic Name |
YER125W |
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| Alias |
HPG1, MDP1, MUT2, NPI1, SMM1, UBY1 |
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| Strain |
S288c |
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| Description |
NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome |
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| External sources |
Open in SGD 
Open in KEGG
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Gene Sequence
Download FASTA
Hide Seq |
>RSP5 YER125W
ATGCCTTCATCCATATCCGTCAAGTTAGTGGCTGCAGAGTCATTATATAAGAGGGACGTA
TTCCGTTCCCCGGATCCGTTTGCTGTTCTGACTATTGATGGTTACCAAACCAAATCTACA
TCCGCAGCGAAGAAAACGTTAAATCCCTACTGGAATGAGACTTTCAAATTCGACGATATC
AATGAAAATTCTATTTTAACCATCCAAGTCTTTGATCAAAAGAAATTTAAAAAGAAGGAT
CAAGGGTTTCTTGGCGTGGTTAACGTCCGCGTGGGTGATGTTTTGGGCCATTTGGATGAA
GATACTGCTACATCGAGTGGTAGACCTCGCGAAGAAACTATTACTCGTGATTTAAAAAAA
TCTAATGACGGAATGGCCGTCAGCGGTAGGTTGATTGTTGTTTTATCAAAACTACCTTCG
TCAAGTCCGCATTCACAAGCTCCTTCTGGCCATACTGCATCTTCTAGTACGAATACAAGT
TCAACTACTCGAACAAATGGTCATTCTACTTCCTCCACCCGTAATCATTCAACGTCTCAT
CCTTCCAGAGGCACCGCGCAAGCAGTAGAATCAACTCTTCAAAGCGGTACAACAGCTGCT
ACTAATACGGCAACAACCAGTCACCGTTCCACCAATTCCACATCCAGTGCTACCAGACAA
TACTCTTCGTTTGAAGACCAGTATGGTCGTTTACCCCCTGGTTGGGAGAGAAGGACCGAT
AACTTTGGTCGTACATATTACGTCGATCATAACACAAGGACTACCACTTGGAAACGTCCA
ACGCTCGATCAAACAGAAGCCGAACGTGGCAACCAATTAAATGCAAATACTGAGTTAGAG
AGAAGGCAGCATAGGGGAAGAACTTTACCTGGTGGATCATCAGATAATTCCTCTGTAACA
GTTCAAGTGGGAGGTGGTTCCAATATACCTCCTGTTAATGGTGCAGCAGCAGCAGCGTTT
GCAGCTACAGGTGGTACCACATCTGGTTTAGGCGAATTACCTTCAGGCTGGGAGCAGCGA
TTTACTCCAGAAGGAAGAGCTTATTTCGTTGACCATAATACTAGAACAACCACTTGGGTG
GATCCAAGGAGACAACAGTATATACGTACTTATGGCCCTACAAATACCACCATTCAGCAA
CAACCGGTCTCCCAATTAGGTCCTTTGCCTTCTGGATGGGAAATGAGATTGACCAATACG
GCACGTGTATATTTCGTTGACCACAATACAAAAACAACGACCTGGGATGACCCAAGACTT
CCATCATCGCTAGACCAAAATGTTCCACAATACAAGCGTGACTTCAGACGTAAGGTTATT
TATTTCAGGTCCCAGCCCGCTCTTAGAATATTGCCGGGACAATGTCATATTAAAGTACGT
AGAAAGAACATTTTTGAGGATGCTTATCAAGAAATTATGAGACAAACCCCAGAAGATTTA
AAGAAAAGATTAATGATCAAGTTTGATGGTGAGGAAGGTTTAGATTACGGTGGTGTTTCC
AGAGAATTTTTCTTTTTATTATCACATGAGATGTTTAATCCATTTTATTGTTTGTTTGAA
TATTCTGCGTATGACAACTATACCATTCAAATAAATCCTAACAGTGGCATCAACCCCGAA
CATTTGAACTATTTCAAATTCATTGGTAGAGTTGTGGGTCTTGGTGTTTTCCATAGAAGA
TTTTTGGATGCATTCTTTGTAGGTGCACTTTACAAAATGATGCTACGTAAAAAAGTCGTA
TTGCAAGATATGGAAGGTGTTGACGCAGAGGTGTATAACTCATTAAACTGGATGCTTGAG
AATAGTATAGATGGTGTCTTGGATCTGACGTTCAGTGCCGACGATGAAAGATTCGGTGAA
GTTGTAACAGTGGATTTGAAGCCAGATGGGAGAAATATTGAAGTTACTGATGGTAATAAG
AAAGAATATGTCGAATTATATACCCAATGGAGAATTGTTGATAGAGTTCAAGAACAATTT
AAGGCATTCATGGATGGTTTTAACGAATTAATCCCCGAAGACTTAGTAACTGTGTTTGAT
GAGCGTGAACTAGAACTATTGATCGGTGGTATTGCGGAAATTGACATTGAAGATTGGAAG
AAACACACTGATTATCGTGGTTACCAAGAGTCAGACGAGGTCATTCAATGGTTTTGGAAG
TGTGTCAGTGAATGGGATAATGAACAAAGAGCCCGTTTATTGCAGTTCACCACTGGTACT
TCTCGTATACCTGTCAACGGGTTTAAAGATTTGCAAGGCTCTGATGGTCCAAGAAGATTC
ACTATTGAAAAAGCTGGTGAAGTACAACAATTGCCAAAATCTCACACATGTTTTAACAGA
GTTGATTTGCCACAATACGTTGATTATGACAGCATGAAACAGAAGCTAACATTGGCCGTG
GAAGAAACCATAGGGTTTGGTCAAGAATGA |
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Promoter Sequence
Download FASTA
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>RSP5 YER125W
ATATTTCTACCTTTTTATATATTGTAAAACGTTTACGCACTTATTTATGTAAACCAGTAA
GCACCCACCCAGCTATGTCGTCATGACTACAAATTGGTTATGAACCAAGCCTTATTCAGT
AAACCAGCAAATTTAACATCATGCCGGCATTGAATCATACATAGAAATCAACACAATAGC
TTTGAGAACTGAGAATGTAGCTTTGACGCTGCTATTATTATTTGGTATTGTTTACCTTTT
AATGTTTATTTGTTTAGAAAACAGACTGCTGGTTTGTTTACATTTGAGAGCAGAAAAAAA
AAATTGCTGGCGCAGACCAGCCGCACAGTCACGTGACAGTATACGATCATGTGATCTTAC
GTACATAATGACATTATACGAGAAAGGGGAAAAAACAAAAATTTAGTGGAAATTTTTGGT
AAAGACCAAATTGCAGTGATCTTCATGGTGAAAGGTAATATTTTTTGCTGGCGGGGGAGG
GGGCTTCTATCTCGACAATTAAAAGACATACGCTTAACCATTTTTAGGGTACTCGAGTAT
CGCATCTGCTAATTGATAAAAGGACTTTGTTGTGTTTTGAGGCTGTTTTCCATTTTCTTC
GTTAGAGCTACAAGAGTCGACTTTTTCGTTAAACAAAAACGATTATAAGATAATAAGCGC
TGTCAGTTTTTTCCACAGTTTTGGACTTGTTACTATAATTCGTGAAGCACATTTTGCAAG
TGAGTCAAAATTTCAGTTCAGTCCTTCTTTAGAAGAGTGAGTGCGTAGCAAATAAAACAG
CAGGAAATAATTGCTTGTTTTTGTGTGTAAGTACCTTTTAGTTGGAACTACCGAATATAG
TGTTATTCGACTTTCACTTTCATAAGCCACAGCTTTTTCTTAGTGCGTTTTTAGTTCGAT
AAATTTACCAAAAACTATTTTCCCCTTTTCTTATTCCCTTTTCTTTGTTAGCTTGGGTAT
TATATTTAAAGTAACAGAAAGGAAAGAAAAAAGAAAAAAA
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| Chr coordinates |
Chr V from 410189-412618 |
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