Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
ECO1
Systematic Name
YFR027W
Alias
CTF7
Strain
S288c
Description
Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>ECO1 YFR027W
ATGAAAGCTAGGAAATCGCAGAGAAAAGCGGGCAGTAAACCAAATCTTATCCAGTCTAAA
TTGCAAGTTAATAATGGTTCGAAATCGAATAAAATAGTCAAGTGTGATAAATGTGAGATG
TCATATTCCTCGACATCAATAGAAGATCGCGCCATCCACGAGAAATACCACACTTTACAG
CTGCATGGACGTAAATGGTCGCCGAATTGGGGTTCTATAGTATACACAGAGCGAAACCAT
TCAAGGACGGTGCATCTATCAAGATCGACAGGGACAATAACGCCATTGAACTCCTCACCT
TTGAAAAAAAGTAGTCCGTCTATTACCCATCAGGAGGAGAAGATTGTATATGTGAGACCA
GATAAGTCGAATGGTGAAGTCCGAGCCATGACGGAGATAATGACACTAGTGAATAACGAG
CTGAATGCGCCACACGATGAGAATGTCATTTGGAACAGTACCACAGAAGAAAAAGGCAAA
GCGTTTGTATACATAAGAAATGACAGGGCGGTCGGAATAATAATTATAGAGAACCTTTAT
GGGGGCAATGGTAAAACATCTAGTCGTGGACGTTGGATGGTTTATGATTCTAGAAGATTG
GTACAGAATGTGTACCCCGATTTTAAGATTGGCATATCGAGAATTTGGGTGTGCAGGACA
GCAAGGAAGTTGGGTATCGCAACCAAATTGATTGACGTTGCAAGAGAAAATATTGTTTAC
GGTGAAGTTATTCCTAGGTACCAGGTAGCATGGTCGCAACCCACAGACAGCGGTGGAAAA
CTGGCTAGCAAATACAACGGCATTATGCATAAATCAGGCAAGTTACTATTGCCGGTATAC
ATATGA
Promoter Sequence
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>ECO1 YFR027W
TTTGCCGCGCAGCCTGTGTAAAATGGCGCACACAATCACGTTACTTGAATCTCAGTTCAG
AAGTTTCTTTCAACACAGCCAATTGCATTTAGTCTGCTATGCTTAATATTGTAGCTACTA
CGTGGCAAACATAGCTGCCCGAACTACTTTATGCGTACGTGTCCACAGCAATTTGTATAA
CGACTCAATCAAAATTCTCTCAAACACCTTCATGGGAATCTGTCGACAATGTAATCAGAT
CTCAGCCCAATTGCCAGTATGTGTTCATATCTTATTCCGTGGCCGCCCCTCCAAAAAGCT
TCAAAATACACTCACCAGGCTTACTTCTTGTTGGGAGAAGAACCGTTATCGTTCACTTGA
TAATATTCCTACCAGTATGTTGTCCTATATGGAGTCATGAGCATACATGGTGCAAAATTA
TGGAATTAGCGCAATGAGTTTCAAACAGCAATTTGATCTTTTTATAAACACTGAAATGCC
AGAATTGATAATGTAATAGGAAAAAAAAATGAAAAGATTCAAAACCGAAGATAAAATGAG
ATTATTTTTTTCTTTTATGTAGAAACATCGATTCGCTTCTGTGGGTTCCCATATCCTCGA
GGAGAACTTCTAATATATTCTGTATAATTAATATTATAGCATTAACAACGGTATAATCTC
AGTCATTATCCCAAAATTCACCTATTTTCCCATCATACCGATCTTTGCGAATACTTGAGC
ATGTAAATCAGAGATTCTATGTAACAGCTGCCCAGAAACCAGAAAACGTCTCTTAACCAC
TTCCATTGTTGGCATGTTGAAACCTCCTGCCGCCTTGATCATCCTTCGACTTAGGGAAGA
ATCTTAACAAATGAAATTTAACGTCAACGCGTAATAGAAAAAAAGCCTTTCGCGTACTGT
AATCAGTAATAATACATAAGGAGATGCCAGCTACAACGGACATCAACATATATCTATGTT
TACATATTAGGGTTCAACAGAATATAAATCGTTGCACAAA
Chr coordinates
Chr VI from 207452-208297