Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
ALG2
Systematic Name
YGL065C
Strain
S288c
Description
Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in N-linked glycosylation pathway; mutants exhibit temperature-sensitive growth and abnormal accumulation of lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; mutations of human ALG2 cause congenital myasthenic syndrome; human ALG2 complements temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>ALG2 YGL065C
ATGATTGAAAAGGATAAAAGAACGATTGCTTTTATTCATCCAGACCTAGGTATTGGGGGC
GCTGAAAGGTTAGTCGTCGATGCAGCATTAGGTCTACAGCAACAAGGACATAGTGTAATC
ATCTATACTAGTCACTGTGATAAATCACATTGTTTCGAAGAAGTTAAAAACGGCCAATTA
AAAGTCGAAGTTTATGGTGATTTTTTACCGACAAACTTTTTGGGTCGTTTTTTTATTGTT
TTCGCAACAATTAGACAGCTTTATTTAGTTATTCAATTGATCCTACAGAAAAAAGTGAAT
GCGTACCAATTAATTATCATTGATCAACTGTCTACATGTATTCCGCTTCTGCATATCTTT
AGTTCTGCCACTTTGATGTTTTATTGTCATTTCCCCGACCAATTATTGGCTCAAAGAGCT
GGGCTATTGAAGAAAATATACAGACTACCATTTGACTTAATAGAACAGTTTTCCGTGAGT
GCTGCCGATACTGTTGTGGTAAATTCAAATTTCACTAAGAATACGTTCCACCAAACGTTC
AAGTATTTATCCAATGATCCAGACGTCATTTATCCATGCGTGGATTTATCAACAATCGAA
ATTGAAGATATTGACAAGAAATTTTTCAAAACAGTGTTTAACGAAGGCGATAGATTTTAC
CTAAGTATAAATCGTTTTGAGAAAAAAAAGGATGTTGCGCTGGCTATAAAGGCTTTTGCG
TTATCTGAAGATCAAATCAATGACAACGTTAAGTTAGTTATTTGCGGTGGTTATGACGAG
AGGGTTGCAGAAAATGTGGAGTACTTGAAGGAACTACAGTCTCTGGCCGATGAATACGAA
TTATCCCATACAACCATATACTACCAAGAAATAAAGCGCGTCTCCGATTTAGAGTCATTC
AAAACCAATAATAGTAAAATTATATTTTTAACTTCCATTTCATCATCTCTGAAAGAATTA
CTGCTCGAAAGAACCGAAATGTTATTGTATACACCAGCATATGAGCACTTTGGTATTGTT
CCTTTAGAAGCCATGAAATTAGGTAAGCCTGTACTAGCAGTAAACAATGGAGGTCCTTTG
GAGACTATCAAATCTTACGTTGCTGGTGAAAATGAAAGTTCTGCCACTGGGTGGCTAAAA
CCTGCCGTCCCTATTCAATGGGCTACTGCAATTGATGAAAGCAGAAAGATCTTGCAGAAC
GGTTCTGTGAACTTTGAGAGGAATGGCCCGCTAAGAGTCAAGAAATACTTTTCTAGGGAA
GCAATGACTCAGTCATTTGAAGAAAACGTCGAGAAAGTCATATGGAAAGAAAAAAAGTAT
TATCCTTGGGAAATATTCGGTATTTCATTCTCTAATTTTATTTTGCATATGGCATTTATA
AAAATTCTACCCAATAATCCATGGCCCTTCCTATTTATGGCCACTTTTATGGTATTATAT
TTTAAGAACTACTTATGGGGAATTTACTGGGCATTTGTATTCGCTCTCTCCTACCCTTAT
GAAGAAATATAA
Promoter Sequence
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>ALG2 YGL065C
ACCTTATTTTCTGTTCCGCTACTATTCCTCAAGAGTTTAATAAAACAATGCAAAGACTAT
TTCCTACAGTGGTTCCTATAATGACACCCAGACTGCATAAGTTACCATTCGCTTTGGACT
TTAAAGTTATAAATTCTGCCTTAAGTCCTTTCAAGGGATCCAAGATCAAAGCATTGGCAC
AAACTTTATATGCTATTTCAAATGATGACACGGAACCAGGGTTCGAGAAAAGATGCATTA
TCTTTGTTAACGAAAAAAAGAATGTTCCTGAAATTGTTAACCTATTGAATAAGAAATTCG
GTCATAATGCCATCGGTTTAACTGGTGAAGATACATTTGAAGAAAGATCCGAGAAAATTA
TGCCCTTTTTATCACCACCGCGACCACTTTCGGAGGTGGTTGCTCAGAGTACTTCACCTC
CCACTTCCTTGAAGAAATTTGAAATTCCTGATTCCAACATCGTCATCGGCAAATTGAAAA
ACACAAATTCTAATGGTACCGCACCCAGTAACAAGTCTTTGCATGTACTCGTAACCACCG
ACCTCATGGCAAGAGGGCTCAATTTCAAAGGTGTACGGAATGTTGTTCTCTACGATGTAC
CCAAAACGTCAATAGACCTGATACACCGAGTGGGCAGAACTGCTAGAATGAAACAGGGCG
GCCGCGTATTTATGCTAACTGACAGTAAAACAAAATCTTGGGCTAAAGCTCTTCCAAAGA
TCATCAAAAAGCACCAGAGATTATCATGATAAATGTATATTCTTGTAAATATTATAACAT
ATATACGAAAGGGTCACAATCACAGATACAATTTATAGATCGAGAGCCTTGCGTATAGCT
TCTTTTTTTATAAACAAGTGCCTGGCTAGATGAACGCGCGAACAACAAAATAAATGATGT
ATTCATTTTAACATCAAAAGATTACGTTCGCCATTTAAGAAGTCACGAAATAGATACAGT
AGTAAAGACAGATAAAAAAGAGTCGATTAGACAAGCAAAA
Chr coordinates
Chr VII from 381271-379760