Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
ERG1
Systematic Name
YGR175C
Strain
S288c
Description
Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; human SQLE functionally complements the lethality of the erg1 null mutation
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>ERG1 YGR175C
ATGTCTGCTGTTAACGTTGCACCTGAATTGATTAATGCCGACAACACAATTACCTACGAT
GCGATTGTCATCGGTGCTGGTGTTATCGGTCCATGTGTTGCTACTGGTCTAGCAAGAAAG
GGTAAGAAAGTTCTTATCGTAGAACGTGACTGGGCTATGCCTGATAGAATTGTTGGTGAA
TTGATGCAACCAGGTGGTGTTAGAGCATTGAGAAGTCTGGGTATGATTCAATCTATCAAC
AACATCGAAGCATATCCTGTTACCGGTTATACCGTCTTTTTCAACGGCGAACAAGTTGAT
ATTCCATACCCTTACAAGGCCGATATCCCTAAAGTTGAAAAATTGAAGGACTTGGTCAAA
GATGGTAATGACAAGGTCTTGGAAGACAGCACTATTCACATCAAGGATTACGAAGATGAT
GAAAGAGAAAGGGGTGTTGCTTTTGTTCATGGTAGATTCTTGAACAACTTGAGAAACATT
ACTGCTCAAGAGCCAAATGTTACTAGAGTGCAAGGTAACTGTATTGAGATATTGAAGGAT
GAAAAGAATGAGGTTGTTGGTGCCAAGGTTGACATTGATGGCCGTGGCAAGGTGGAATTC
AAAGCCCACTTGACATTTATCTGTGACGGTATCTTTTCACGTTTCAGAAAGGAATTGCAC
CCAGACCATGTTCCAACTGTCGGTTCTTCGTTTGTCGGTATGTCTTTGTTCAATGCTAAG
AATCCTGCTCCTATGCACGGTCACGTTATTCTTGGTAGTGATCATATGCCAATCTTGGTT
TACCAAATCAGTCCAGAAGAAACAAGAATCCTTTGTGCTTACAACTCTCCAAAGGTCCCA
GCTGATATCAAGAGTTGGATGATTAAGGATGTCCAACCTTTCATTCCAAAGAGTCTACGT
CCTTCATTTGATGAAGCCGTCAGCCAAGGTAAATTTAGAGCTATGCCAAACTCCTACTTG
CCAGCTAGACAAAACGACGTCACTGGTATGTGTGTTATCGGTGACGCTCTAAATATGAGA
CATCCATTGACTGGTGGTGGTATGACTGTCGGTTTGCATGATGTTGTCTTGTTGATTAAG
AAAATAGGTGACCTAGACTTCAGCGACCGTGAAAAGGTTTTGGATGAATTACTAGACTAC
CATTTCGAAAGAAAGAGTTACGATTCCGTTATTAACGTTTTGTCAGTGGCTTTGTATTCT
TTGTTCGCTGCTGACAGCGATAACTTGAAGGCATTACAAAAAGGTTGTTTCAAATATTTC
CAAAGAGGTGGCGATTGTGTCAACAAACCCGTTGAATTTCTGTCTGGTGTCTTGCCAAAG
CCTTTGCAATTGACCAGGGTTTTCTTCGCTGTCGCTTTTTACACCATTTACTTGAACATG
GAAGAACGTGGTTTCTTGGGATTACCAATGGCTTTATTGGAAGGTATTATGATTTTGATC
ACAGCTATTAGAGTATTCACCCCATTTTTGTTTGGTGAGTTGATTGGTTAA
Promoter Sequence
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>ERG1 YGR175C
GGATAAGCTGTTCACAAAATCTCTTCTCGAGTATGGGTTCGATGTGGCTATTCCAAGCAA
CGCAAGAAGGTTTTTACCAAACGATGAAGAGTTAAGAGATTCTTATAAATACGGCTCCAA
CGTTGGAGGTTCGCATTACGCCTATCTAATCTCCTCATTCGACATTCCCGAAGGTGACAA
TGACAAGTTTTGGAGTCTTGTCGAATACTACTATGACCGCTTTTTAGAATCGTACGACAA
CGGTGACCACTTGATTGGTCTGGGGGTCCTACAACTTGATTTTATCGTTGAAAACAAGAA
TATAGACAGCCTTCTTGCCAACTCTTATTTGCACCAGCAAAGAGGCGGTGCAATCATCAG
TAATACAGGACTTGTCTCGCAAGATACGACCAAGCCGTACTACGTTCGGGATTTAATCTT
CTCGCAGTCTGCAGGCGCCTTGAGATTTGCGTTCGGCCTAAACGTTTGCTCCACAAACGT
GAATGGTATGAACATGGACATGAGCGTGGTTCAGGGCACTCTACGGGATCGTGGCGAATG
GGAATCGTTCTGCAAGCTCTTCTACCAAACCATCGGCGAATTTGCGTCGCTTTAATGCGA
TACTGCCGTAGCGGGCCTTCGTATAGCTCGGCCGAGCTCGTACAAAAGGCAAGCAGTGTA
TCGGACAGAGCTGATATAACACAATACGCTCGTAGTCGATGCATGCCGTGGCTGCTCTCG
GTCGGGTATAAGTCTTAGACAATAGTCTTACCTCGCATGTATAATAAATCTTTTGTATTT
AATCTATTATATGTTTCTATGCTTTTTTTTCCTATTGTTGTTTGCTTTTCCTTTTCCTTA
TTTCTTTCTAGCTTCTAATTTTCTTTCTTTTTTTTTTTTTTTTCATTGAAAATTATATAT
ATATATATATATCAGAACAATTGTCCAGTATTGAACAATACAGGTTATTTCGAACAATTG
AAAAAAAAAAATCACAGAAAAACATATCGAGAAAAGGGTC
Chr coordinates
Chr VII from 848423-846933