S.cerevisiae - Yeastract

Locus Information

Standard Name	UBR1
Systematic Name	YGR184C
Alias	PTR1
Strain	S288c
Description	E3 Ub-ligase (N-recognin); recognizes and ubiquitinates N-end rule pathway substrates in complex with Rad6p; Roq1p-bound form accelerates degradation of misfolded and native ER membrane and cytosolic proteins as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; role in ER-associated protein degradation; modifies Cup9p to regulate peptide transport; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
External sources	Open in SGD Open in KEGG

Gene Sequence Download FASTA View Seq	Sequence hidden
Promoter Sequence Download FASTA	>UBR1 YGR184C CCCCGGTAACGTCGAAGAGAATGGTTTACTGTCATTTGTCCAATATGTCATTGCACCAAT CCAAGAATTGAAGTTTGGTACAAATCACTTCGAATTCTTCATTGATAGACCAGAAAAGTT CGGTGGTCCAATTACCTACAAATCCTTCGAAGAAATGAAATTGGCTTTTAAAGAAGAAAA ATTGTCCCCACCTGATCTAAAAATTGGTGTTGCTGACGCTATCAACGAGCTATTGGAGCC AATCAGACAAGAATTTGCCAACAACAAGGAATTTCAAGAGGCCTCCGAAAAGGGTTATCC AGTTGCCACACCACAAAAGTCGAAAAAGGCTAAGAAACCAAAGAATAAGGGTACTAAGTA CCCAGGCGCTACTAAGACCAACGAGATTGCCACGAAACTAGAGGAAACCAAATTGTAAGC ATAGCTTAATCCGTTTTCACGATTCATAATATAATAAATAAGAAAAGATATATCATATAA ACGTTATAAAATTAATAACCGGGTAAGTGTAGAAAAGTGATGCGACGGTTTATTTTCTCT TCCTCTTGCGATTGAATTTAACTTGCAGATAGTGACCATAAGGCAACTACCCAGTGGCAA ACAGTTTTGATAACGCCCAGTACATCAACGAGCGAGTATAAAGACTTTGGTACATTTTAA AAAGGAAACATATATTGTTTTCATTGCTAGACCCTTTTAGTCTCACCTCAATAAAACTGC TTTATTCCTCATTGGGCTTTTTATTCTTTAATTTTGCATACTTATAGCGTGAAACTGGGC ATTTAACAAAAGCAAACTATTTTAATAGTAGCATCCTGCTTTCTTTGCCCCTCCTTCTTA TTGCGATACATTATTAAGTTTTTTTACCACCTTTCTTCCTTTTTCTTCGCATCTTCGGAC AAAGGCAGTTGAAGTTTACTGTATCCTATTAGTTGACTATTTTCTCTCACTGAAGTCCCT AATCTTTACAGGTCACACAAATTACATAGAACATTCCAAT
Chr coordinates	Chr VII from 865753-859901