Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
COS8
Systematic Name
YHL048W
Strain
S288c
Description
Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>COS8 YHL048W
ATGAAAGAGAATGAAGTCAAAGATGAGAAAAGCGTAGATGTGTTATCCTTCAAACAGCTC
GAATTCCAAAAGACCGTTCTACCTCAAGATGTTTTCCGAAACGAATTGACCTGGTTTTGT
TATGAAATTTACAAGTCTTTAGCGTTTCGCATCTGGATGCTGTTATGGCTACCACTTAGC
GTCTGGTGGAAACTTTCCAGCAATTGGATTCACCCACTTATAGTTTCACTTCTTGTCCTG
TTCCTGGGACCATTTTTTGTCCTTGTTATTTGTGGACTTTCTCGTAAGCGTTCCTTATCG
AAACAACTCATTCAGTTTTGCAAAGAGATTACTGAAGACACACCAAGTTCGGATCCTCAT
GATTGGGAAGTCGTTGCAGCAAATCTAAATTCGTACTTCTATGAAAATAAGACTTGGAAT
ACCAAGTACTTTTTTTTCAATGCCATGAGCTGCCAAAAAGCGTTTAAAACAACCCTTCTC
GAACCCTTCTCTTTAAAAAAAGACGAATCTGCAAAGGTTAAGTCATTTAAGGATTCCGTT
CCTTATATCGAAGAGGCCTTGCAAGTGTATGCTGCAGGATTTGACAAAGAGTGGAAGCTG
TTTAATACTGAGAAGGAAGAGAGTCCTTTCGACCTGGAAGACATTCAGCTCCCCAAAGAA
GCTTACCGATTTAAGCTTACCTGGATTCTTAAAAGGATTTTCAACCTGCGGTGTTTACCA
CTCTTCCTTTATTATTTTTTAATTGTCTACACGTCTGGAAATGCTGACCTTATATCACGT
TTCTTGTTTCCGGTAGTAATGTTTTTTATCATGACGAGAGATTTCCAAAATATGAGGATG
ATTGTTTTATCCGTGAAAATGGAACACAAGATGCAGTTCTTGTCAACTATTATAAATGAG
CAAGAAAGTGGTGCGAATGGATGGGACGAAATTGCAAAGAAAATGAATAGGTATTTGTTT
GAGAAAAAAGTCTGGAATAATGAAGAGTTTTTCTACGATGGACTTGACTGCGAATGGTTT
TTTAGGCGCTTTTTCTATCGTCTCTTATCTTTAAAAAAACCTATGTGGTTTGCTTCGTTG
AACGTTGAGCTATGGCCATACATTAAAGAAGCGCAATCGGCCCGCAATGAGAAGCCCCTA
AAGTAG
Promoter Sequence
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>COS8 YHL048W
ACTCAATTTATATACACTTATGCCAATATTACAAAAAAATCACCACTAAAATCACCTAAA
CATAAAAATATTCTATCCTTCAACCATAGTACATAAACACACTCAATTGCGTATCAATAC
CACCATGACGTCATTAACTTAAATGTTCCTTAATACCGTCATACCACTATGCTCTATTCC
ATATATTGTAATATAACTGTACTCTATAGTCATACAGACGCTTTTACTTCACCCTATCTT
CTCATACTATTGTCATAGAATCTCACACTGACGCATGATTAAAACGAATAATTTTTACTA
TAAGGCCTCCCATCCGTGCTCTACCCTTTTGTTTGCAATATTTATACAGAATCTCAAAGC
AAGCGGGAGAAGTGGTGATTACCCAGATGTCATGCATGATCTGAGCACCACCGTACCTCT
AGGTTTTGCCTTGATCAATTTTACAGTGACACCAAGCATAAGGATAAAAAATGGTATTGA
AAGGTTGTCCACATTTGTAAGTAACTTGGTTCTATGAATCTTCATGTCAGATACGTAGGA
CGGACTCTTTCCTGTGTAAATATTTGTGACAGCTACGTCTATTTTCTACTAGATGTTTAC
ACAGTTTTGTCACAGGAAATCTACGCTTAAAATATGTATTTCATTCAAGCGGTAACCGCT
GTACGAGCAGTGACATTGCTGGTCGCACCTTAAATGTAAACCAAAGTTACGGCACACCGT
GATGCACCCGCATTAAAGTTTTGTAAATTCGTTATTACGATTATCGAGTTGGCTAGATAG
AAAACCGGAAATGAAATGGATGCCCTTTTCGAATAGCTGAGTTTCTTTGCCTAAAATAGC
CCAATATTGTTTCCCTTTTTCTATCACGAGGTTACTGAGCCATTGCATGAACGCGCGCGC
CTCGGCGGCTTTTTTTTTCTGCTGTGCTGTATAAAAGCGAAAAGTCAGAAGTTACTATTT
CGAATAAAAAACCCCTCGAACTGCCATCTCACTACCGAAA
Chr coordinates
Chr VIII from 6401-7546