Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
PRP8 Systematic Name
YHR165C Alias
DBF3, DNA39, RNA8, SLT21, USA2 Strain
S288c Description
Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>PRP8 YHR165C
ATGAGTGGACTACCGCCCCCACCTCCTGGTTTTGAAGAGGACAGCGACTTAGCACTTCCA
CCACCACCACCACCACCGCCTGGATACGAAATCGAAGAACTGGATAATCCGATGGTGCCA
TCATCGGTAAATGAGGATACATTCCTTCCGCCTCCACCACCTCCTCCAAGCAACTTCGAA
ATAAACGCTGAAGAAATTGTGGACTTCACATTACCACCGCCACCACCCCCTCCAGGTCTA
GATGAATTAGAGACTAAAGCAGAAAAGAAAGTAGAATTACATGGAAAGAGAAAATTGGAC
ATAGGAAAAGATACTTTCGTCACTCGAAAATCAAGAAAGCGTGCAAAAAAAATGACCAAA
AAGGCAAAGAGAAGCAATTTATATACTCCTAAAGCCGAGATGCCACCGGAACATCTGCGA
AAGATTATTAATACTCACAGTGACATGGCCTCCAAAATGTACAATACTGATAAAAAGGCT
TTTCTAGGCGCTCTAAAGTATTTACCGCACGCGATTTTAAAATTGTTAGAGAACATGCCT
CATCCATGGGAGCAAGCCAAAGAAGTTAAAGTTTTATATCACACTTCAGGAGCCATAACA
TTTGTGAATGAAACACCAAGAGTAATAGAGCCTGTATATACTGCCCAATGGTCAGCTACT
TGGATAGCAATGAGGAGAGAAAAACGAGATAGAACACATTTTAAAAGAATGAGATTTCCA
CCTTTCGATGATGACGAACCACCTCTGTCATATGAACAGCACATAGAAAATATCGAGCCA
CTGGATCCTATAAATCTTCCCTTAGACTCTCAAGATGATGAATATGTTAAAGATTGGCTC
TACGATTCCCGGCCCTTGGAGGAGGATAGTAAAAAGGTCAATGGTACATCTTATAAAAAG
TGGAGTTTTGATTTACCTGAAATGTCGAACTTATATAGGTTATCAACGCCACTTAGAGAT
GAAGTAACTGACAAAAATTACTATTATCTTTTCGATAAAAAATCTTTTTTTAACGGTAAA
GCCCTTAATAACGCAATCCCTGGAGGTCCTAAATTTGAACCTTTATACCCAAGAGAAGAG
GAGGAAGATTATAACGAATTCAACTCTATAGATAGAGTAATATTTAGGGTTCCTATTAGA
AGCGAATATAAGGTAGCGTTTCCTCATCTATATAATTCCCGGCCCCGTTCAGTGCGCATA
CCATGGTATAATAATCCAGTGTCGTGTATTATCCAGAACGATGAGGAGTACGACACGCCT
GCACTTTTTTTTGATCCATCGCTGAACCCAATACCTCACTTTATTGATAATAATTCATCC
CTCAACGTATCAAATACAAAGGAAAACGGTGATTTCACTTTACCTGAAGATTTTGCACCT
CTTTTGGCTGAAGAAGAAGAACTTATTTTGCCAAATACAAAAGATGCGATGTCGTTATAT
CATTCACCTTTTCCATTTAATAGAACTAAAGGAAAAATGGTGAGAGCACAAGATGTTGCC
CTGGCTAAAAAATGGTTTTTGCAACATCCTGACGAGGAGTATCCCGTTAAAGTTAAGGTC
TCTTACCAAAAGCTCTTGAAGAACTACGTGCTAAATGAATTGCACCCTACTTTGCCAACA
AACCACAACAAAACTAAGTTATTGAAGAGTTTAAAAAATACCAAGTATTTTCAACAAACT
ACAATTGATTGGGTAGAGGCAGGACTCCAGCTATGTCGACAAGGACACAATATGTTAAAT
TTATTAATCCACAGAAAGGGCCTAACTTATTTACATCTCGACTACAATTTCAATTTAAAA
CCAACTAAAACCTTAACCACAAAAGAACGTAAAAAGTCAAGACTTGGAAACTCATTTCAT
TTGATGCGTGAATTGCTAAAAATGATGAAACTGATTGTAGATACACATGTGCAGTTTAGG
TTAGGAAATGTAGATGCCTTCCAGTTAGCAGATGGTATACATTATATTTTGAACCACATA
GGACAATTGACCGGTATTTATCGTTATAAATATAAAGTAATGCATCAAATCCGCGCATGT
AAAGATCTGAAACATATCATATATTATAAGTTTAATAAAAATTTGGGAAAAGGACCTGGT
TGTGGATTTTGGCAACCTGCGTGGAGAGTGTGGCTAAATTTCTTAAGAGGCACTATACCA
CTACTCGAAAGATATATTGGAAACCTTATCACACGTCAATTTGAAGGCCGTTCTAATGAA
ATTGTCAAAACTACAACTAAACAAAGACTTGACGCCTACTACGATCTTGAGTTACGAAAC
TCGGTCATGGATGACATTTTAGAAATGATGCCTGAGAGTATTCGACAGAAAAAGGCAAGA
ACTATACTGCAACATTTAAGTGAGGCTTGGAGATGTTGGAAGGCTAATATTCCATGGGAT
GTTCCTGGTATGCCAGCCCCAATCAAAAAAATAATTGAACGGTATATAAAATCCAAAGCT
GATGCCTGGGTATCTGCAGCTCATTACAATCGAGAACGTATAAAGCGTGGAGCTCACGTC
GAAAAGACTATGGTTAAAAAAAATCTGGGGCGTTTAACGAGACTTTGGATCAAAAATGAG
CAGGAACGTCAAAGGCAAATACAGAAAAACGGTCCCGAAATTACTCCCGAAGAGGCTACG
ACCATATTTTCTGTTATGGTTGAGTGGCTTGAATCAAGGAGCTTTTCACCAATACCATTT
CCACCTTTAACTTACAAAAATGATACTAAGATATTAGTTCTTGCCCTCGAAGACCTAAAA
GATGTCTACGCATCAAAAGTACGTTTAAATGCATCTGAAAGGGAAGAACTTGCGTTGATA
GAGGAGGCTTATGATAATCCTCACGATACTTTGAACAGAATCAAAAAGTACTTGTTGACC
CAGCGAGTTTTTAAGCCTGTTGATATAACCATGATGGAAAACTATCAAAACATTTCCCCT
GTTTATTCAGTTGATCCCTTGGAAAAGATTACCGATGCATATCTTGATCAGTATTTATGG
TACGAAGCTGACCAACGAAAGCTTTTCCCAAACTGGATTAAACCAAGTGATTCAGAGATA
CCACCTCTTCTGGTATACAAGTGGACTCAGGGTATAAACAACCTATCTGAAATTTGGGAT
GTATCCAGAGGCCAATCTGCAGTTTTGCTTGAGACTACTTTGGGTGAAATGGCCGAAAAA
ATTGACTTTACTTTACTTAATAGATTACTTCGCCTGATTGTAGATCCTAATATTGCTGAC
TATATCACTGCAAAAAATAATGTTGTTATCAACTTTAAAGATATGAGTCACGTCAACAAA
TATGGCTTAATACGCGGGTTGAAGTTCGCTTCTTTCATATTCCAATATTACGGACTAGTT
ATAGATCTTTTACTATTGGGTCAGGAAAGGGCTACAGATTTGGCTGGTCCAGCTAACAAT
CCAAATGAATTTATGCAATTCAAGAGCAAAGAAGTAGAAAAGGCACATCCGATCAGACTT
TACACCAGATATTTAGATCGTATATATATGCTTTTTCACTTTGAAGAAGATGAGGGAGAG
GAATTGACTGATGAATACTTGGCAGAGAATCCAGATCCAAACTTTGAAAACAGCATCGGA
TACAATAATAGAAAATGCTGGCCCAAAGATTCGCGCATGAGGCTAATACGTCAGGACGTT
AACCTAGGGCGAGCAGTGTTTTGGGAAATTCAAAGTAGGGTGCCAACTTCGTTAACGTCA
ATTAAATGGGAAAATGCTTTTGTTTCCGTATACAGTAAAAACAATCCGAACTTACTCTTC
TCTATGTGTGGTTTTGAAGTCAGAATATTACCAAGACAAAGAATGGAAGAGGTGGTTTCT
AACGATGAAGGTGTTTGGGATTTAGTTGACGAAAGAACCAAGCAAAGAACTGCAAAAGCA
TATTTAAAGGTATCTGAAGAAGAAATCAAAAAATTTGACAGCAGAATAAGAGGCATATTG
ATGGCCTCCGGTTCAACCACTTTTACTAAAGTGGCCGCTAAATGGAACACTTCACTGATA
TCCCTTTTCACATACTTTAGAGAAGCCATTGTTGCCACGGAGCCGTTATTAGATATCCTG
GTGAAAGGAGAAACAAGAATTCAAAACCGTGTCAAACTTGGTTTAAATTCGAAAATGCCA
ACAAGATTTCCACCTGCTGTTTTTTATACACCAAAAGAACTTGGTGGGTTGGGTATGATT
AGTGCTTCTCATATTTTAATTCCTGCATCTGACTTAAGTTGGTCAAAACAGACCGATACT
GGAATTACGCATTTTCGTGCTGGTATGACGCACGAGGATGAAAAATTAATCCCAACTATC
TTCCGTTACATCACTACTTGGGAAAATGAATTTTTAGACTCTCAAAGGGTGTGGGCCGAG
TATGCAACGAAAAGGCAGGAAGCTATTCAGCAGAATAGGAGGTTAGCTTTTGAAGAACTT
GAAGGATCGTGGGATCGTGGTATACCTCGTATTAGCACTTTATTTCAAAGAGATCGACAT
ACTCTAGCGTATGACAGAGGTCACAGAATCCGTAGGGAATTTAAACAGTACTCTCTAGAG
AGAAACAGCCCCTTTTGGTGGACAAACTCCCACCATGACGGTAAATTATGGAATTTAAAT
GCCTATAGAACTGATGTGATTCAAGCCCTAGGAGGTATTGAAACAATTTTGGAACACACT
TTATTTAAGGGGACTGGTTTTAATTCATGGGAAGGTTTGTTTTGGGAAAAGGCGTCCGGG
TTTGAGGATTCCATGCAATTTAAGAAGCTAACTCATGCTCAAAGAACTGGTTTAAGCCAA
ATTCCAAATCGTAGATTTACCTTATGGTGGTCACCAACTATTAACAGAGCAAATGTCTAT
GTCGGTTTCTTGGTGCAATTGGATCTGACTGGTATCTTCCTCCATGGTAAAATTCCTACG
TTAAAAATATCTTTAATTCAAATATTCCGTGCTCATTTGTGGCAAAAAATACATGAAAGT
ATAGTTTTTGATATTTGTCAAATTCTCGATGGTGAGCTAGATGTTTTGCAAATTGAATCT
GTGACTAAAGAAACAGTGCATCCCCGCAAATCGTACAAGATGAATTCATCTGCCGCTGAC
ATAACTATGGAAAGTGTTCATGAATGGGAAGTTTCAAAACCCTCCCTATTACATGAAACA
AATGACTCATTTAAGGGATTGATTACCAACAAAATGTGGTTTGATGTACAATTGAGATAC
GGTGATTATGATTCTCATGATATATCTCGTTATGTGAGGGCAAAATTCCTCGATTATACA
ACAGATAATGTCAGCATGTATCCCTCCCCAACAGGTGTTATGATCGGTATCGATTTGGCT
TATAACATGTATGATGCCTATGGTAATTGGTTCAACGGATTAAAACCTTTGATACAAAAT
AGTATGAGAACAATTATGAAAGCTAACCCAGCATTATATGTCCTTCGTGAACGTATTAGA
AAAGGTCTTCAAATATATCAATCTAGTGTACAGGAACCATTTTTAAACTCCTCAAACTAT
GCCGAGTTATTCAATAACGACATTAAACTCTTCGTTGACGACACTAATGTGTATAGAGTT
ACTGTCCACAAGACTTTTGAAGGGAACGTTGCTACAAAAGCAATTAATGGTTGCATTTTC
ACTTTAAATCCAAAGACTGGGCATCTGTTTCTGAAAATTATCCATACCTCTGTATGGGCC
GGTCAAAAACGTTTAAGCCAATTGGCCAAATGGAAAACAGCTGAGGAAGTTAGTGCTCTT
GTGAGATCTTTGCCCAAAGAAGAGCAGCCAAAACAAATTATCGTCACAAGAAAGGCAATG
CTTGATCCTTTAGAGGTTCACATGCTTGACTTTCCTAACATAGCAATCAGGCCAACAGAG
CTGCGACTACCATTTTCAGCTGCAATGTCAATAGATAAACTTTCTGATGTTGTGATGAAA
GCTACTGAACCTCAGATGGTTCTGTTTAACATTTATGATGATTGGTTAGACCGTATTTCA
TCGTACACTGCATTTTCTAGACTTACACTACTTTTAAGAGCTTTAAAGACGAACGAGGAA
AGTGCCAAAATGATTCTACTCAGTGACCCCACGATCACTATCAAATCGTACCATTTATGG
CCTTCATTCACTGATGAACAATGGATCACTATCGAATCTCAAATGAGAGATTTGATTTTG
ACTGAGTACGGCAGAAAATACAATGTCAATATATCTGCCTTAACTCAAACGGAAATTAAA
GATATTATATTGGGTCAAAATATCAAGGCACCATCTGTGAAGAGACAAAAAATGGCTGAA
TTAGAAGCTGCCAGGTCAGAAAAGCAGAACGACGAAGAAGCTGCAGGTGCATCAACTGTT
ATGAAAACTAAAACTATCAATGCGCAAGGTGAGGAGATAGTTGTAGTAGCTTCCGCTGAT
TACGAAAGTCAAACGTTTAGTTCAAAGAATGAATGGAGAAAATCTGCAATTGCTAATACA
CTATTATATTTGAGGTTAAAAAACATTTATGTTTCGGCTGATGATTTCGTGGAGGAACAG
AATGTTTACGTCCTTCCAAAAAATTTATTAAAGAAGTTTATTGAGATATCCGATGTGAAA
ATCCAGGTGGCGGCCTTTATTTATGGTATGTCAGCAAAAGATCATCCGAAGGTGAAAGAA
ATCAAGACTGTTGTGCTGGTACCTCAATTAGGCCACGTAGGATCCGTTCAGATAAGCAAC
ATCCCTGACATCGGAGACCTTCCGGATACTGAAGGCCTTGAACTACTCGGTTGGATCCAT
ACCCAGACAGAAGAACTTAAATTCATGGCTGCGTCTGAAGTAGCAACTCATTCTAAACTT
TTTGCGGATAAGAAAAGAGACTGCATTGATATTTCAATTTTTTCCACCCCGGGATCAGTA
TCATTAAGCGCTTATAACCTGACCGACGAAGGTTACCAATGGGGTGAAGAAAATAAGGAT
ATAATGAACGTGCTATCGGAAGGGTTTGAGCCTACTTTCAGCACGCATGCCCAATTACTT
CTCTCTGACCGTATCACAGGTAATTTTATAATTCCATCTGGAAACGTTTGGAACTACACA
TTTATGGGAACAGCATTTAACCAAGAAGGTGACTACAATTTTAAATACGGCATTCCTTTG
GAATTCTATAATGAGATGCATCGTCCAGTACACTTTTTACAGTTTAGCGAATTGGCGGGG
GACGAAGAGTTAGAGGCCGAACAAATCGATGTATTTAGCTGA Promoter Sequence
Download FASTA
>PRP8 YHR165C
CCTACTCCAATATTCTATACGTCATGCAGAAGAATTCAAAATTAGCCTATTTGGCGCAAT
TCGTCTCCCAAATAGATAGATTTAGACCGGAAACATGTTGTATCATAGCGAACTATTACA
GTGCCCGACAGGAACATGAAAAATCTATCATGTATTTCCGTCGAGCACTAACTTTGGATA
AAAAAACAACAAACGCATGGACTTTGATGGGTCACGAATTTGTTGAACTAAGCAATTCAC
ATGCCGCAATAGAATGCTATCGTCGGGCCGTAGATATATGCCCTCGAGACTTCAAAGCAT
GGTTTGGTTTGGGCCAGGCTTATGCTCTCCTGGACATGCATTTATATTCTCTTTACTACT
TCCAGAAAGCTTGCACTTTGAAACCTTGGGATCGTCGGATTTGGCAAGTATTGGGAGAAT
GTTATAGTAAGACGGGAAATAAGGTAGAAGCTATAAAATGCTACAAAAGATCCATAAAAG
CTTCACAAACGGTCGATCAAAATACTTCAATATATTACCGGTTAGCGCAACTATATGAAG
AACTTGAAGACTTGCAAGAATGTAAGAAGTTCATGATGAAATGTGTAGATGTGGAAGAAC
TTCTGGAAGGTATAGTAACAGATGAAACCGTGAAGGCTAGGCTTTGGCTGGCAATATTTG
AGATTAAGGCAGGAAACTACCAATTGGCTTATGATTATGCCATGGGGGTATCTAGTGGAA
CGTCTCAAGAGATTGAAGAGGCTCGTATGCTGGCTCGGGAGTGCAGAAGGCATATGTAGT
GAAGTGAACATACACATAGCTATTCGTACTAAATGATATGAAATTTTTATAAATGCCAGG
CTATATAGCTATTTAAAGTGACCATGGCAGAAGGATGAACCGAGGTAATACGGCTAGTAC
AAAAGCAACAAAGTTAGGAATACAATTTGAGAAACGAAGACCATAGAAAATACTTGTGCG
ATTGAACTTCCTTCCAAAAAAAAAATAGCGTCAAAGAAAG
Chr coordinates
Chr VIII from 436948-429707
