Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
SSM4
Systematic Name
YIL030C
Alias
DOA10, KIS3
Strain
S288c
Description
Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>SSM4 YIL030C
ATGGATGTTGATTCTGACGTTAATGTCTCCAGGTTAAGAGATGAACTGCATAAGGTGGCA
AACGAGGAAACAGATACCGCCACTTTCAATGATGATGCGCCATCCGGCGCCACCTGCCGT
ATTTGTCGTGGAGAAGCTACTGAGGACAATCCTCTTTTCCATCCTTGTAAATGCAGGGGC
TCAATTAAATACATGCATGAATCCTGTCTGTTGGAATGGGTAGCTTCAAAAAATATAGAC
ATTTCAAAACCAGGCGCGGATGTTAAATGTGACATCTGTCACTATCCCATTCAATTCAAA
ACGATATATGCGGAAAACATGCCCGAAAAGATACCTTTTTCTTTACTACTATCCAAGAGC
ATCTTGACATTTTTCGAAAAAGCTCGTTTGGCTTTAACGATTGGTTTGGCCGCTGTACTA
TATATTATCGGTGTTCCTTTGGTATGGAACATGTTTGGAAAATTATACACCATGATGCTA
GATGGATCATCCCCTTATCCTGGTGATTTCCTAAAGAGTTTGATTTATGGTTATGATCAG
TCAGCAACTCCAGAATTAACCACGAGAGCAATTTTTTACCAACTTTTACAAAACCATTCG
TTTACGTCTTTACAATTTATTATGATAGTGATACTACATATAGCATTGTACTTTCAATAC
GATATGATAGTAAGAGAGGATGTTTTCAGTAAAATGGTTTTCCACAAGATAGGTCCAAGA
TTATCTCCCAAGGACTTGAAATCACGTTTGAAGGAAAGATTCCCCATGATGGATGATAGA
ATGGTTGAATATTTAGCGAGGGAAATGAGAGCTCATGACGAAAATCGTCAAGAGCAAGGT
CATGATAGACTGAACATGCCAGCCGCAGCAGCAGATAATAATAATAATGTTATTAATCCC
AGAAACGATAACGTTCCACCTCAGGATCCTAATGACCATCGGAATTTTGAAAACCTTCGC
CACGTAGACGAATTAGATCATGATGAGGCTACGGAAGAGCACGAGAACAACGACTCTGAC
AATAGTTTACCATCAGGTGATGATTCGTCACGAATTTTACCGGGGTCTTCAAGTGACAAC
GAAGAAGATGAAGAAGCAGAGGGGCAACAGCAACAGCAGCAACCAGAAGAAGAGGCAGAT
TACCGTGATCATATAGAGCCCAATCCGATTGACATGTGGGCAAATCGTCGTGCGCAAAAT
GAATTTGATGACCTAATCGCTGCTCAACAGAACGCAATAAACAGGCCCAACGCTCCGGTT
TTCATCCCACCACCTGCCCAAAACAGAGCTGGAAATGTCGATCAAGACGAACAAGACTTT
GGCGCAGCTGTTGGTGTGCCACCAGCACAGGCTAACCCAGACGATCAAGGACAAGGCCCT
CTAGTGATAAATCTCAAATTGAAATTGTTGAATGTCATTGCTTATTTCATAATTGCCGTA
GTTTTCACCGCAATATACCTGGCAATTTCCTATTTGTTTCCAACTTTTATTGGGTTCGGT
TTGTTGAAAATTTATTTTGGTATATTTAAGGTTATTTTGCGTGGGTTGTGCCATCTTTAC
TACTTGTCTGGCGCTCATATAGCTTACAATGGGCTGACGAAACTGGTCCCTAAAGTAGAT
GTCGCGATGAGTTGGATTTCAGACCACTTAATTCATGACATCATTTATCTTTACAACGGC
TACACTGAAAACACCATGAAGCACTCAATTTTCATCAGAGCTTTACCTGCTTTAACGACG
TATCTAACCTCAGTCAGTATCGTTTGTGCTTCATCCAATCTTGTCTCGAGGGGTTATGGC
CGTGAGAACGGAATGAGCAACCCTACTAGAAGGCTGATTTTCCAGATTTTATTTGCACTC
AAATGCACTTTCAAGGTGTTCACTTTATTTTTCATCGAATTGGCTGGATTCCCCATTCTA
GCTGGTGTAATGCTAGATTTCTCATTATTTTGCCCAATCCTGGCATCCAATAGTCGGATG
CTTTGGGTTCCTTCAATATGCGCAATATGGCCTCCATTTTCCCTTTTCGTATACTGGACG
ATTGGTACTCTCTACATGTATTGGTTTGCCAAATATATCGGAATGATTAGGAAAAATATC
ATTAGACCAGGTGTTCTATTCTTTATCAGATCTCCAGAAGATCCTAATATTAAGATCTTG
CATGATAGTTTAATTCATCCGATGAGTATTCAATTATCAAGGCTTTGCTTATCCATGTTT
ATTTATGCGATTTTTATTGTCTTAGGTTTTGGCTTCCATACTAGAATTTTTTTCCCATTC
ATGCTCAAATCGAACTTATTATCCGTTCCTGAAGCTTATAAACCAACATCAATTATTTCA
TGGAAGTTCAATACAATTTTGCTAACTTTATATTTTACGAAGAGGATCCTGGAGTCTAGC
TCTTACGTTAAACCCTTATTGGAAAGGTATTGGAAAACAATTTTTAAGTTATGTTCAAGA
AAATTACGTTTATCATCCTTTATCTTAGGTAAAGATACCCCAACAGAGAGAGGCCATATT
GTTTACCGCAATTTGTTTTACAAGTACATTGCTGCCAAGAATGCAGAATGGTCAAACCAA
GAACTTTTCACTAAACCAAAGACTCTAGAACAAGCAGAAGAATTGTTTGGGCAAGTTCGT
GACGTTCATGCTTATTTTGTCCCCGATGGCGTTTTAATGCGTGTTCCTTCTTCTGATATA
GTATCCAGAAATTATGTACAAACAATGTTTGTCCCCGTTACAAAGGATGATAAGCTGTTG
AAACCATTAGATTTGGAAAGAATTAAAGAGAGAAACAAACGTGCTGCTGGTGAATTTGGT
TATTTAGACGAACAAAACACGGAATATGATCAATATTATATCGTTTACGTCCCTCCAGAT
TTCCGTTTACGCTATATGACATTGCTTGGCCTGGTTTGGTTATTTGCTTCCATTTTAATG
CTTGGTGTTACATTTATTAGTCAAGCTTTAATAAACTTTGTTTGTAGTTTCGGCTTTCTT
CCAGTCGTAAAGCTATTGTTAGGTGAAAGAAATAAGGTCTATGTTGCATGGAAGGAACTC
TCTGACATTAGCTACTCCTATTTGAACATTTATTATGTCTGTGTCGGATCTGTTTGTTTA
TCCAAGATTGCTAAGGATATTCTTCATTTTACAGAAGGCCAAAACACTCTCGATGAACAT
GCCGTTGACGAAAACGAAGTAGAGGAAGTGGAACACGATATACCAGAGAGAGATATCAAC
AATGCCCCTGTTAATAATATCAATAATGTGGAAGAGGGTCAAGGAATTTTCATGGCCATC
TTTAACAGTATATTTGATAGTATGTTGGTGAAGTATAACCTGATGGTGTTTATAGCTATC
ATGATTGCGGTTATTAGAACTATGGTTTCGTGGGTCGTCTTAACCGATGGTATACTAGCC
TGTTACAATTATCTCACCATCAGAGTGTTTGGCAATTCTTCATACACTATTGGTAATTCC
AAATGGTTTAAATATGACGAGAGTTTGTTATTCGTCGTTTGGATCATTTCGTCAATGGTC
AATTTCGGAACCGGATATAAGTCATTGAAACTATTTTTCAGAAACAGAAATACTAGTAAA
TTGAACTTCTTGAAAACAATGGCTTTGGAACTGTTTAAACAAGGTTTCCTGCACATGGTA
ATTTACGTCTTGCCGATTATTATTTTATCCTTAGTATTTTTACGTGATGTTTCTACAAAG
CAGATTATCGATATTAGCCATGGATCCAGGAGTTTCACTTTATCGCTTAACGAATCATTC
CCAACATGGACAAGGATGCAAGATATTTATTTCGGACTACTGATAGCATTAGAGTCATTT
ACGTTCTTTTTCCAAGCAACTGTGCTGTTCATTCAATGGTTCAAAAGTACTGTACAGAAT
GTAAAAGACGAGGTTTACACTAAGGGTAGAGCTTTAGAAAATTTACCAGATGAAAGTTAA
Promoter Sequence
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>SSM4 YIL030C
CAACTGTAAAAATTGGATGCATTTTTTCCTATTATACCTTTTTCTAACCGCTTCTAACTT
AATTGTTCAATTGGCCTATTTTTCAAAAGAAATGTGTAGTCAGGGTATAAACGTTCCTGG
AACGAAGAAACCAGGTAATAGAGTTTATTTATCGGTTATCATACTAATGGGGAACGGGTG
ATAGAACTTTTACCAATGAAAAGAAATCAGCAGGCCATAATTTGGCTTTATTAAAATTAA
TAACATTATGGTGCTGTTGCGTTTATTAAAACAGACTAAAGCTGTTGGAATGAAATTCTA
ATGTTATCTATTTAGTAGTAATAGCATCACATGCGGTGTAAGAGGATGGCGTAAATTATG
AGAAGCTGTCATCGAGGTTAGAGGAAGCTGAAATACAAAAATTGATAATGTAATAGGAGA
ATGAAACATATAAAACGGAATGAGGAATAATCGTAATATTAGTATATAGAAATATAGATT
CCATTATGAGGATTCCTAGATCCTCGAGGAGAACTTCTAGTATATTCCGTATACATAATA
TTATAAGCCTTTATCAACAATGGAACCCCCAACAATTATCTCAAAATTCACCCATATCTT
AATTAGTAACATGAATAGTACTAAACAGATGATATTTTAAAGTTTCATTCCAACAAGCAT
CTTAAATGTGCTATTACTTCCTAAAATAAGTAGTTTTTCCAACGAAATAGCCTTGTTGGC
GCAATCGGTAGCGCGTATGACTCTTAATCATAAGGTTAGGGGTTCGAGCCCCCTACAGGG
CTATCTTTTTACCATTTTCAATTCAATAGAAAAATTAAATCATTAGAGACGGAAAACTGG
TTGAAAACGCATCGATTGAGGACATTGAAAAGATGATTATGACCGATCTATGAAGCCATA
AGATTACGTTAAGAATAGTTCTTTGTTACTGATTTCAAAAACTGTTTTTTTAGCCAAGAG
TACCACTAATTGAATCAAAGAGACTAGAAGTGTGAAAGTC
Chr coordinates
Chr IX from 300009-296050