Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
MPH1
Systematic Name
YIR002C
Strain
S288c
Description
3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>MPH1 YIR002C
ATGGCTAGTGCAGATGATTACTTTAGTGATTTCGAAGATGACGAGCTGGATAAACTGTAT
GAAAAGGCTATCAATAAATCTGTGAAGGAAACTATAACGAGACGTGCTGTACCAGTTCAA
AAAGACCTTCATGATAACGTTTTACCTGGGCAGAAAACTGTGTACGAAGAAATTCAAAGA
GATGTCAGTTTTGGACCCACTCATCATGAGCTTGATTACGATGCTTTGTCGTTCTACGTG
TACCCTACAAATTACGAGGTAAGGGATTATCAGTATACAATTGTTCACAAATCACTGTTT
CAAAATACGTTATGCGCCATCCCAACGGGTATGGGTAAAACGTTCATTGCCAGTACAGTA
ATGTTAAATTATTTTCGTTGGACCAAAAAAGCCAAAATAATCTTTACTGCTCCAACAAGA
CCTTTGGTAGCCCAGCAAATTAAGGCATGCTTAGGTATAACAGGAATACCTTCGGATCAA
ACTGCTATATTACTCGATAAAAGCAGGAAAAATAGAGAAGAAATTTGGGCCAATAAGAGA
GTTTTCTTTGCCACACCGCAAGTAGTGGAGAATGACTTGAAGAGGGGTGTATTGGATCCT
AAGGATATTGTATGTCTTGTCATCGATGAAGCTCACAGAGCTACTGGCTCCTCTGCGTAT
ACAAATGTGGTAAAATTCATAGATAGGTTCAATTCATCATACAGATTATTAGCATTGACC
GCTACACCAGCCTCTGACCTGGAAGGTGTCCAAGAAGTGGTTAATAACTTAGATATTTCC
AAGATTGAAATTAGGACTGAAGAAAGCATGGATATCGTGAAATATATGAAGAAAAGAAAA
AAGGAAAAAATTGAAGTGCCCCTTTTGTTGGAAATTGAAGACATAATCGAACAATTAGGT
ATGGCCGTCAAACCAGTGCTTCAACAGGCAATTGAACTCGGTATATATGAGGAATGTGAC
CCTTCACAAATAAACGCCTTCAAAGCCATGCAACAAAGCCAAAAAATTATTGCTAACCCT
ACTATACCTGAAGGAATTAAGTGGAGGAACTTCTTTATTTTACAGTTATTGAACAATGTG
GGTCAAATGCTAAAGAGATTAAAAATTTATGGAATAAGGACATTTTTCAATTACTTCCAG
AATAAATGTACAGAATTCACTACGAAATATAATCTTAAAAAATCTACTAATAAAATTGCA
GCTGAGTTTTATTACCATCCGATTTTGAAAAACATCAAAAATCAATGCGAAAATTATTTA
AGTGATCCAAAGTTTGTCGGTCATGGGAAGTTACAATGTGTTAGAGATGAACTAATGGAC
TTTTTTCAGAAAAGGGGTTCCGACTCGAGGGTTATTATTTTTACAGAATTAAGAGAAAGC
GCACTTGAAATTGTGAAGTTCATAGACTCGGTAGCTGACGATCAAATCAGGCCTCATATT
TTTATTGGACAAGCTCGTGCAAAAGAAGGTTTTGATGAGGTCAAATACACAAGAAAACAT
GCGCCAAAGGGAAGGAAGAAGGTAGAGAGATTGCATAGGCAAGAGCAAGAGAAATTTTTG
GAAGCTGAACGAACTAAGAGAGCGGCGAATGATAAACTTGAAAGAAGTGCCAGACGAACG
GGGAGCTCTGAAGAGGCTCAGATTAGCGGAATGAACCAAAAAATGCAAAAAGAGGTTATC
CATAATTTCAAAAAGGGTGAATATAATGTTCTCGTTTGTACATCAATTGGAGAAGAAGGT
TTGGATATCGGAGAAGTTGATTTAATAATCTGTTATGATACTACAAGTAGTCCAATCAAA
AATATTCAGCGTATGGGTAGAACAGGCAGAAAACGAGATGGTAAGATAGTACTACTGTTT
AGCAGTAATGAATCATACAAATTCGAGCGTGCTATGGAAGACTATTCAACCCTGCAAGCG
CTTATATCCAAGCAATGCATTGACTATAAAAAATCAGATCGGATAATCCCTGAAGACATT
ATTCCGGAATGTCACGAGACATTGATCACGATTAATGATGAAAACGAAATAATTAATGAA
ATGGAAGATGTTGACGAAGTTATTCGTTATGCGACTCAGTGTATGATGGGCAAAAAGGTG
AAGCCAAAAAAAGCCATAACAAAGAAGAAGAGAGTTCAGGAAAATAAAAAACCGAAGAAG
TTCTTTATGCCTGATAATGTTGAGACCAGTATTGTTAGTGCAAGCACTTTAATTAATAAG
TTCTTGGTGAATGAAAGTGGCGGGAAACAACTAGTAACGAGTAATGAAAACCCAAGTAAG
AAGCGGAAGATTTTTAAAGCTTTGGATAATCTGGAGAATGATTCAACCGAGGAAGCTTCC
TCCTCATTAGAAACTGAAGATGAAGAAGTCAGTGATGATAATAATGTTTTCATTGCGGAA
GGGCAGAATGGATGCCAAAAAGATTTGGAAACTGCCATTATTCGCACTGGCGAAAGTCTT
ACCACACTCAAGCCACTTCATAATTTTGAACGCCCTAATATGGCTTTATTTGTGAATGAT
TGTGGTCTTCCAACTAAAATCGAGAAAAATGTGAAAGACATCCGAGGAAATCAACACAAC
CTTGAAAAAGAAAAGAGCTGTACTGTTGACAAGAATAACATGGTATTGAGTTTGGACGAT
TGGAATTTTTTCAGAAACCGCTATATCCCAGAAGGTGTTTCCTTCGATGTGGAGCCCAAT
TTTGTACAATACACCAAAGGGGTAAAAGTTCCGCATTGTCACAAAGTTTCAAAAATCATT
ACGTTATTTAACGACGAGAGTAATGATAATAAGAAGAGGACAATTGATATGAACTATACT
AAATGTTTGGCGAGAGGCATGTTACGAGACGAAAAAAAATTTGTAAAAGTTAACGATAAA
AGTCAAGTCGATAACAACAGTGTCAACCATGATTCATCCCAATCTTTTACCTTATCGAAC
GCAGAATTAGATGACATACTGGGCTCAGATTCTGATTTTTGA
Promoter Sequence
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>MPH1 YIR002C
AAATTAGAAGGTGAAATAGCAGACTCATTGCCCTCAGCACCCTCGTGCTCATTTTTTTCG
AGTGGGGAGGGATTTGTAGAAGTTTTGTTATCTGATGCACTTCTTTGCCCGTTTTGATGA
ATGGCGGCCACCTTTCCCTCTTCCACAGAAGTTGGACTTTTTTTCCTGGAAACATTGTGT
ATATTGTGCTTTGAAATCAAACTTTCAATCTCCTCTAACTCCTTACTGGTGTTATTCATT
ACATTATTTAGTTCTTCAGTAGTGGAGCGTCTAACTGGCCTCTGCAATGGTACCTTGGGC
AAACTCTCTTGATCCATACCACTCTCAAACGAAGTCATCGTCTTTGCTTTAAGTATGGGT
CTACGTGTTGGTACATTGGGCGTTCCTGCTGGTGTTGGTGGCTCGCTATTAGCTTTAATA
TCTCCTGATTCAGAGCCGGATAACGGAAACAGCTCAGATGTCTTCCTCCTTGAGGGCCTC
TCAGGTACTTTTGGCGTAACTTCCGATGGCATTGTATAATCGGTCAAAATAGATTTCCTG
TTAGATCACCAACAAAACATGATACTTTCTAAATCAGAAAGCTTAAATTAAAATATACTC
AATATTTCTCCTTTTCTTTTGCTTCGCGCCTGGTAAAACAAGATTGCTTTCATTGTGCAT
GTGGTAGAAAAGACAAGTTAAAAAAGGAGAATGTACTAACACAAAATTCAAACTCCAAAG
GGGATAATTGCACTCAATTTGCAAGGTTGTTCCATATGAGACAGGAGTCTTCTTCTCCAT
CGACCTTCCTAGCTTACTGTGCTCACAGAAAGACATAAACCGGGTAACGGCTTTTACGGG
GTTACGTGTGTATATAACCGGGCATCACGAAGAGATCAATAGAGGTGCCCTATGCTCTAT
CACGGAGCTAAGATATTGTGATTCAAGATATAGTAGCTCACTTCAGTTTTATTCAACACA
TTCCGGTTCTGTTTTATTTTAGTGTCCTTTTTTCTCTCTG
Chr coordinates
Chr IX from 360396-357415