Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name HAM1
Systematic Name YJR069C
Strain S288c
Description Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA
External sources Open in SGD external link
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Gene Sequence
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Promoter Sequence
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>HAM1 YJR069C
AATCCTTCGTCAATGACAAGTCTGAGTTGTTGAAGCACGAAGTGGCCTACGTGTTGGGTC
AAACCAAGAACTTGGACGCTGCTCCAACTTTAAGACACGTTATGTTAGATCAAAATCAAG
AACCAATGGTGAGACACGAAGCCGCTGAGGCTTTGGGTGCCCTAGGTGACAAGGATTCGT
TGGATGACCTAAATAAGGCTGCTAAGGAGGATCCACACGTTGCTGTGAGAGAAACCTGTG
AACTGGCCATTAACAGAATCAACTGGACCCATGGAGGTGCCAAGGATAAGGAAAACTTGC
AACAATCCCTATACTCGAGTATTGACCCAGCCCCACCTCTACCATTAGAAAAGGATGCTA
CCATCCCAGAACTACAGGCCTTATTGAATGATCCTAAGCAACCTTTGTTCCAAAGATACA
GAGCCATGTTCAGACTGAGAGATATCGGTACTGATGAAGCAATCCTGGCCTTGGCCACTG
GTTTCAGTGCAGAATCCTCCCTTTTCAAGCATGAAATCGCCTACGTCTTCGGTCAAATAG
GTAGTCCGGCTGCTGTCCCAAGTTTGATTGAAGTTTTGGGCAGAAAGGAAGAAGCTCCAA
TGGTTAGGCATGAAGCTGCTGAAGCCTTGGGTGCCATTGCTTCTCCAGAAGTTGTCGACG
TCTTGAAATCTTACCTCAACGATGAAGTCGATGTCGTCAGAGAATCTTGTATCGTTGCGC
TAGATATGTATGATTACGAAAACAGCAACGAACTAGAATATGCTCCAACTGCTAATTAGA
AGAATCAGCATCATCAATAATGATAGTAACAATAATCATTGTATAATCTTGTATTTTATA
CTTTTCAAAACCCGCCATTTCCGTTATATATACAAATGTATCAAATAGCAAAAAAATTAT
TTATTTTCGAAACCGTTCTCTCGAGCTTCAGCTTTCAACACTGGTCTTCAAAGCATAGGA
AACACTCACATAGAGATATCTAAAAACGAACGATAGCAGA
Chr coordinates Chr X from 569399-568806
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