Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
STE24
Systematic Name
YJR117W
Alias
AFC1, PIO2
Strain
S288c
Description
Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>STE24 YJR117W
ATGTTTGATCTTAAGACGATTCTCGACCATCCTAATATCCCGTGGAAATTAATCATTTCT
GGGTTCTCGATTGCCCAATTTTCTTTCGAATCTTACTTGACGTACAGACAGTACCAGAAG
CTATCTGAAACAAAGTTGCCACCTGTGCTGGAAGACGAAATTGATGATGAAACTTTTCAT
AAATCAAGGAACTACTCCCGGGCCAAGGCCAAGTTCTCCATTTTCGGTGACGTCTATAAC
CTAGCCCAAAAGCTAGTTTTCATCAAATACGACCTCTTCCCTAAAATCTGGCACATGGCC
GTTTCTTTATTGAATGCAGTCCTGCCAGTCAGATTTCATATGGTCTCCACTGTCGCACAG
AGTTTATGCTTCTTGGGTCTCTTATCCAGTTTGTCTACCTTGGTTGATTTGCCACTCTCT
TACTATAGCCATTTTGTCCTGGAAGAAAAATTTGGTTTCAATAAATTGACCGTCCAACTA
TGGATCACCGATATGATCAAGAGTCTGACTTTGGCGTATGCTATTGGTGGCCCAATCCTT
TACCTGTTCCTTAAGATCTTTGATAAATTCCCTACTGATTTCCTTTGGTACATTATGGTC
TTCTTGTTCGTTGTCCAAATCTTAGCCATGACAATCATTCCAGTCTTCATCATGCCCATG
TTTAATAAGTTCACTCCATTGGAGGACGGTGAACTGAAAAAATCTATTGAAAGTTTGGCC
GATAGAGTTGGGTTCCCTCTAGATAAGATTTTTGTCATTGACGGCTCAAAAAGATCTTCT
CATTCAAACGCATATTTCACAGGTTTGCCATTCACCTCCAAGAGAATTGTTTTGTTCGAC
ACTTTAGTGAACAGTAATTCTACTGATGAAATTACGGCTGTTTTGGCCCATGAAATCGGT
CACTGGCAAAAAAACCACATCGTTAATATGGTCATCTTTAGTCAATTGCACACCTTCCTC
ATTTTCTCCCTTTTCACCAGCATCTACAGAAATACATCATTTTACAACACCTTCGGCTTT
TTCTTAGAGAAGTCCACTGGCAGTTTTGTTGATCCCGTTATCACTAAGGAATTCCCCATT
ATCATTGGATTTATGTTATTTAACGACTTATTAACTCCACTCGAATGTGCCATGCAATTC
GTGATGAGTTTAATTTCCAGAACTCATGAATATCAAGCTGATGCTTATGCTAAAAAATTG
GGCTACAAGCAAAATCTATGTAGGGCTCTAATTGATCTACAAATCAAAAACCTTTCCACC
ATGAATGTAGATCCTCTGTATTCTAGCTATCATTATTCCCATCCAACTCTAGCTGAAAGA
TTGACCGCTCTAGACTATGTTAGTGAAAAGAAGAAAAACTAA
Promoter Sequence
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>STE24 YJR117W
GCACTACACCACGATCCGTGACCCACTGCTGAAAATTGATTTCAATGTCCACACCGTCTC
GATGATCCAGGCTGTCGTCTCGAACACCGTCCTGTTGCCCACCCTCACGACGCCAATGCA
TTATAATGTTGTCACCTACACAGATTCGTACAGTTCAATGGTATCTTCCCTCAGCGCAGG
GTACTTTATCTGGGACTTGACTATGTGCGTGCGTTACTTCAAGCTTTATGGTCTCGAGTT
CACGGGCCACGCCATTGGCTCCGTATATGTGATGCTGTTGTCCTTAAGACCGTTCTGCCA
ACCCTGGATCGGCAGGTTCCTTATCTACGAGGCCTCCACTCCCTTTGTGAACATCAATTG
GTTCATCATGCAATGTAACGCCAAGAGCAAGAACTCTATCCCTCTGTGGTTTAATGTCGT
CAATGGCCTTTTGCTCATGACTGTGTTTTTCGTCGTCAGGATTTGCTGGGGCTCCATCGC
ATCCGCTCTCTTATTCAGGCAGATGTGGAAGGTAAGAGACGAGTTACCCAAGTTTTCTGC
TGTCACGATGATGTCGCTGAACATTTTCATGAACCTTTTGAACGTGCTTTGGTTCAAGAA
GATGATTAGAATCGCCAAGAAACTTGCAAAACCAGCCCCAACGTCGAAGCTAGACTAAAC
CTACCTTTTTTTCTATCTTCAACAACGAAACGCCTTACACACACACACACATACATCTAC
ATACATACATACAAATATACATATATGTAAACTTGTATATTCATTCCTATTAACCAAAAA
GAGGCAATTAAACTTTTCCCTCTTTTTCTACGTCATTTACTCAAAAACTCTAATTCCTTC
GTCTCTGTTCTGCCATTTTCTCCAGAAAAAAATCGACGGGAAATAAAAAAAAAAAGACAA
CGAACAAGAGAAAAAGTTCGCGAATTATAAACCACTTCTATAATTAACAGGAAAAGGAAG
GAAAAAAAAGGAGGAAATAGAAAACTGCAGGCCTTTATTC
Chr coordinates
Chr X from 642007-643368