Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
DBR1 Systematic Name
YKL149C Alias
PRP26 Strain
S288c Description
RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant External sources
Open in SGD
Open in KEGG
Gene Sequence
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>DBR1 YKL149C
ATGACTAAATTGCGAATTGCTGTACAAGGGTGCTGTCATGGTCAGCTAAACCAAATTTAT
AAAGAAGTGTCACGAATCCATGCGAAGACTCCCATCGATCTATTAATTATTCTTGGAGAT
TTTCAAAGTATTCGTGATGGTCAGGATTTTAAGTCAATAGCCATACCACCAAAATATCAA
AGACTCGGTGATTTCATATCATACTACAATAATGAGATTGAAGCCCCAGTCCCTACTATT
TTTATTGGCGGTAATCATGAATCGATGAGACATTTAATGCTTCTGCCACATGGTGGTTAT
GTAGCAAAGAACATTTTTTATATGGGATACTCTAACGTTATATGGTTTAAAGGCATAAGG
ATAGGTTCATTGAGCGGGATATGGAAAGAGTGGGATTTCAATAAGCAACGACCAGATTGG
AATGACCTAGAAAATAACAATTGGAAAGCTAACATAAGAAATCTGTATCATGTAAGAATT
TCTGATATTGCTCCTCTTTTTATGATCAAGCATCGTATTGATATTATGCTGAGCCACGAT
TGGCCCAATGGAGTCGTTTATCATGGCGATACTAAGCACTTGTTGAAGCTTAAGCCTTTT
TTTGAGCAAGATATTAAAGAGGGAAAACTAGGCAGCCCAGTGACCTGGCAACTACTAAGA
GATTTGCGGCCTCAATGGTGGTTGAGCGCCCATTTGCATGTCAGGTTCATGGCCTCCATT
AAGCATAATAAAAGAAGCCACGAACCGCCTAATAAGTCAACTTCAAAGACAAAAAAAAAC
AATAATGAAATAGATTTGGATTTATCCAGTGACGAGGACGAAAGGTCTGGTATTATGAAT
TGCCAAGAAGAGAATGAGTATGATTCCAAATACGGCGAGACACGGTTCTTGGCGTTGGAC
AAGTGCCTGCCAAGAAGACGTTGGTTAGAAATTCTGGAAATAGAACCGGATACATCGCAT
GCTTCGTGGAAGGACGAGAATCACCGTATGTTCTGGGATCCTGAATTTATCAATAATTTG
GTAATTTGTCAAAAAAATAAGAATCTCCTAAGCAATAAACCGTTTAATAGCGTCAATTGG
ATAGAACTGTCTCAATCTAATAGAGAGGAAGGAAGGGATATTGATTGGGAAAATTATGCC
ATTCCTGCATACACCTTAGATATTCAGAAAGATGAAGTACGACAAACTAAAGCATTTATC
TCTAAATTCATGACTTGA Promoter Sequence
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>DBR1 YKL149C
CCGCTTGTGTTTCTGTCCATGGTGCCAATAGATTAGGTGCCAATTCCTTGTTGGATCTTG
TTGTCTTTGGTCGTGCTGTTGCCCATACGGTTGCTGACACTTTACAGCCTGGGTTGCCAC
ACAAACCACTACCTTCTGATTTGGGTAAAGAATCCATCGCAAACTTGGATAAACTAAGAA
ATGCTAATGGTTCAAGATCTACGGCAGAAATTAGAATGAATATGAAACAAACTATGCAAA
AGGATGTTTCCGTCTTTAGAACACAATCATCTTTAGATGAAGGTGTTCGGAACATTACTG
CAGTAGAGAAGACCTTTGATGATGTGAAGACGACCGATAGATCAATGATCTGGAATTCTG
ACTTGGTTGAAACTCTGGAGCTACAGAACTTATTAACCTGTGCCTCCCAAACAGCTGTTT
CCGCTGCTAATAGAAAGGAATCCCGTGGTGCTCATGCAAGAGAGGATTATCCAAATAGAG
ATGACGAACATTGGATGAAGCATACATTATCCTGGCAAAAGGACGTCGCTGCCCCAGTGA
CTTTGAAATACAGAAGGGTTATCGATCACACTTTGGACGAAAAGGAATGTCCTTCCGTAC
CTCCAACTGTAAGAGCCTACTAATTTGAACCTCATTGTATTTTACGGAAAAGAATATCAT
ACTCTTCTTTAATTGCACTTTTTTTGTGCGTTTGCACTTTTTTACCACTGACTCACTAAT
TTGTATATATACCTATTAATATACATTTACATAAAGTTTCTTCTTATACATACTCTATTT
ATTTAGTTATTTATTAACTTACTATTTATTTATTTATTTATTTATTTATTTATTACTTTC
AATTTTTTATCGAGGCATTTCCTTAGTTCTCCAATTTTTTTTCTCATTAGCCAGATGTGT
GTTTTTCTGGCCCTCACAAAAAATGAGCAGGAGAAAGTCATATGGCGAACGTAAATATGT
AACTAAAAATTAAGATGGGCAGACATTTATCATTTTGCTT
Chr coordinates
Chr XI from 168829-167612
