Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
SRL3
Systematic Name
YKR091W
Alias
WHI7
Strain
S288c
Description
Repressor of transcription at Start; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; inhibitor of Start that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger Start; Srl3p is unstable and degraded by SCF-Grr1 after Cdc28p-dependent phosphorylation; contains a GTB (G1/S transcription factor binding) motif; binds SBF-regulated promoters in HU-treated cells; Cdc28p substrate
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>SRL3 YKR091W
ATGTTTCTTAAGACACCTAATTGGGAAACGGTAAATGAGACTCCCAAATCGAGAGTCTTA
ACGATAAACGAATTGATCTCTCCCAACCTGGATACTGAATCTAACAGCCTTCTGGCGACG
CCGGCAAGGAAATATTTCAAAACTTCAATAAGTGAAGCGCAAGATTCTCCTACATCTGCC
CCTTCGCCCGATGGCAATGAGGATCCCACATATCAATACAACGTACAATTTCATTTTCCA
GGACCAATAACACCTACAACACCCAGGTCTAAGAATGCAGAAATGTTTCCATCCCCCACG
CCCCCATTGGTTTCTCCCACAGCGGTTATCGAGGAAGAGAATGACGATTCCGTACGGGAG
TTTTCACGCACGCTAAAATCAAGACTCAACTGCGCAATGGTTAAGCTATCAAAGGAACAT
GAGCAAGTAGCTTTGATTCCTCCACCTCCGACGGAAAAGATACGAAAGGGCTCTTATAGT
AATAAATTTGCCGCTAAGCATAGGCGCTGTCACTCGTTAGATGAATCCAAAAAGTTTCTG
AGTTCTCTGGAAGATTCATCCGCTCATGCAGCGTTCTTGAAGGCAATTTCGTCCAAACAT
GCCAAAAGCAATAGGGTAGACAACGTTAACGTTTCGCCGTTACGTTGGTCATCTCATAGA
AGAACGCAAAGTACACAGGAGAATTCTTTACAAGAAGTTGTTGCTATCGATACATTATTG
AAGATGTCCTCATCGGACTGA
Promoter Sequence
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>SRL3 YKR091W
ACGGCGGCACTACGAGATACAGCTCTGATGCAGATTATAAAGAAACGGAGCCCATTGAGT
TTAAATATCCGCCTGGGGAGGGACCTTGCAGAGCATGCGGCTTGGAAGTCACAGGGAAAA
GAATGTTTTCCAAAAAGGAAAACGAACTGTCGGGTCAATGGCATCGTGAATGTTTTAAAT
GCATTGAATGTGGTATCAAATTCAATAAACATGTTCCCTGTTATATTCTAGGCGATGAAC
CATATTGTCAAAAGCACTATCACGAGGAGAATCACAGTATTTGTAAGGTTTGTTCAAATT
TCATAGAGGGTGAATGTCTGGAAAATGATAAGGTGGAACGATTCCACGTGGATTGTCTAA
ACTGTTTCTTATGCAAGACTGCCATTACTAATGATTATTATATATTCAATGGGGAAATTC
CATTGTGCGGTAATCACGACATGGAAGCTCTCTTGAAGGAAGGTATCGACAATGCTACAT
CAAGCAATGATAAGAACAATACTCTCTCTAAAAGGAGAACGAGGCTCATCAACTTCAACT
AGCATCACTACCCATTTGTCTTTCCTAGCACACATGTTTCATAACATTCTTAATAAGATT
TTGATTTTTTATATTATTAGCCAGCCTTGTTCATTTATAAATTGTATAGCGCAGGAAAAA
GGCATCTGCCTATCTATGGTATCAACAACATTAGTCGTCATTAGTTAGTTAGTTATAAAG
ACATCATTCACTCATATTCACTACGTTGTCTTCTTCTCAACAACTACCTCTAACTGTTTT
TTTACGCGTCATTTAATTGTAGCGAATTTCTATTTTTGGACATTCTCGTACCGGTGCATT
AAAGGCTAAAAGCTAAAAAGGGAACAGGAGCCTAAGAATAGAGAATAAGGAAATTTATTT
AAGGAAAGGCTAAGCAATGAAATGTTTCGTTATTTTATTGTATTTTCAAGAGGATGGAAG
AAGAACCTGAGCACAAACGGATAAATAATAGACGAATATA
Chr coordinates
Chr XI from 611525-612265