Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name SIC1
Systematic Name YLR079W
Alias BYC1, SDB25
Strain S288c
Description Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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>SIC1 YLR079W
ATGACTCCTTCCACCCCACCAAGGTCCAGAGGGACTAGGTACCTTGCGCAGCCTAGTGGC
AATACTAGTTCTAGTGCCCTAATGCAAGGTCAAAAGACCCCCCAAAAGCCTTCACAGAAC
CTAGTCCCTGTCACTCCCTCAACAACTAAGTCTTTTAAAAATGCGCCATTATTAGCACCT
CCCAATTCGAACATGGGTATGACCTCTCCATTTAATGGGCTTACGTCTCCTCAACGCTCG
CCGTTTCCAAAATCTTCAGTGAAGAGGACACTATTCCAATTTGAAAGTCATGATAATGGA
ACAGTAAGGGAAGAGCAGGAACCATTGGGTCGTGTAAATAGGATATTGTTTCCCACGCAG
CAAAATGTGGATATAGATGCAGCAGAAGAAGAAGAAGAAGGAGAAGTTCTTCTTCCCCCC
AGCAGACCTACATCTGCCAGGCAGTTACATTTATCACTTGAAAGAGATGAGTTTGATCAG
ACACATAGAAAGAAGATTATTAAAGATGTACCTGGTACGCCCAGCGACAAGGTGATAACA
TTTGAATTGGCAAAAAATTGGAACAACAACTCTCCGAAAAATGACGCCAGGAGTCAAGAA
AGTGAAGACGAGGAAGACATCATCATCAATCCAGTGCGGGTGGGTAAAAATCCCTTTGCA
TCAGATGAACTGGTCACTCAGGAAATTAGAAATGAACGTAAAAGGGCAATGTTGAGAGAA
AACCCAGATATAGAAGACGTAATAACATATGTCAATAAGAAGGGAGAGGTGGTAGAGAAA
CGAAGGTTAACGGATGAAGAAAAGAGAAGATTCAAGCCAAAGGCATTGTTTCAATCTAGG
GATCAAGAGCATTGA
Promoter Sequence
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>SIC1 YLR079W
CCGTTTATTGATAGAGGTGATAGTTTGTTCCGAAACACCCAATGTTCTTAGGCCATTTGA
CATTCTATCTTGTACCTTGGATAAAATTTTGTTTTGTTCCACTATATTTTCGAATGATTG
TTGGCCCATTTCTAGAATGTAATCTAATTGAGCGTTACCCCTTTCGAAAACAGACTGTTC
CTTTTGTAGCCCTTGGTACAACGGTAGTCCCCCACCGTTGCTAGAGCCCTCTTTACCATT
TGCACTCGCACCACCAACGTTCCTTTTATTCATGATGGTCTCTGATGTACTAAAGGGGTT
ATCGGAGTCCATAACATGCGATGCTCCTGAGCCAAACAACTGAGTTCTGGAATTATTTTC
GTTGTAGGATTGTTTTAAATCCTTAAACTTGGCAGTAAAGTCGTGCAGATCCTGTGTTAA
AGTTGCTAGTCGATTAGCGAACTTAGGATCAATTTCCTCTGCATTAGTATCTTCTTTATA
TCTGTTTAAATGTTCTGCATATTGCTTAACTGTTTTCTCCAGTGAGACCAGAGTTGCAGA
GATGGACCCTTGTAAAGAAATAGGGGCGGTCACAGAATTCTTTTCAAACCTGGCCAACTC
TTGTTGTAGTTGATTTTTTTGCTTCACAGCATGGTTGTAAAGAGCGTTCTATTTGATGGT
AGTAGCAAAATACCCTGTTAGTATTACATCTTGTTTTAGCAATAATGAGAAAAGATGCCT
CCGGCGATCAAACATACCATTCCCCCCTCAAATCAATATGATTAAGTCACGATAATATCT
GCACTATTGCCGTGTTTCCTTCTCCATCGACAGCGTCGATCCTGTCTATTATAGCCAGCA
CACTGAAAATTTCAATGGCTGGCTTGTTGTTCGCGTCGCAACTTTTGATATTTATAAAAA
GAGAGAAGGCATATCCAAAGGATAAGGTATTGTCTTTGTAAATCAATCAACCAAACCTCT
ACGGAATTTTGACCCTTGAAGCAGGGACTATTACACGAAA
Chr coordinates Chr XII from 286820-287674
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