Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
HMG2 Systematic Name
YLR450W Strain
S288c Description
HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA View Seq
Sequence hidden Promoter Sequence
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>HMG2 YLR450W
ACAAGAAAGCAGAGAAAGTTAAAGACTCGGAAGAGAGCAAACCAAAGCCAAAGACGAAGC
TACTGGAAGGCGGTATTATCATTGAAGACCGCGTCACAGGAAAAGGCCCACATGCCAAAA
AGGGTACCAGAGTTGGAATGAGATATGTTGGTAAGTTGAAGAACGGGAAAGTTTTTGACA
AGAATACAAAGGGTAAGCCTTTTGTTTTTAAGTTGGGCCAAGGCGAAGTAATTAAAGGAT
GGGACATCGGTGTTGCTGGTATGGCGGTCGGTGGTGAGCGTAGAATTGTCATTCCTGCTC
CATATGCCTACGGTAAACAAGCTTTGCCCGGTATTCCTGCTAACTCTGAATTGACATTTG
ATGTTAAATTGGTCTCCATGAAATAGGGTCCTTAATGCATACGTATTGATATATGTATCT
ATAATACTATATACAATTATCTATACTTCCATTACTAATATTATCTTTCAATTTTACATG
TTTTTTTCTGCCATAAAAAAGCAATATTTTTTTGCGAGCTATTTAGTGATATAGCCGCCC
AGCTACTTGTCGATGCATATATTGGCTGAGAGTACTAATACAATTATCGGAAGACCTCAA
AGTAAAATATAGAAGCTTTGAGTAAAAGGAGCTCGAGTTTTAAAAATGACTTCGTAATAT
GTAAAGTTTATGTCATATATACTTACACGATAAATAGACCATTGATCGTTAGAGACGAGC
GCATTGTTTTGTTGAATCCCTTTCAACAGCGCGACAAAAGTTAATCGAGAACAATAAGAT
GTTGCATTCAAGGGTTAGTCAAACATATCAGAAGGCCGTTTTCTAAATCACCTCAAGAAC
CTACCACACAGATACATCTTGAAGAGGTGGAGTACCAAAGGGAATATTTTGTACGAGCAA
GTTATAGTAAGACACTTCAGTGAGAAATTAATCTGACTTACTTTTACTTAATTGTGTTCT
TTCCAAATTAGTTCAACAAGGTTCCCACATACAACCTCAA
Chr coordinates
Chr XII from 1032627-1035764
