Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
SRC1
Systematic Name
YML034W
Alias
HEH1, YML033W
Strain
S288c
Description
Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SRC1 has a paralog, HEH2, that arose from the whole genome duplication
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>SRC1 YML034W
ATGAATAGTGACTTGGAGTATTTAGAGGACGGTTTTGATCCGAATTCAATGAAAGTTGCG
ACTTTGAGGAGGATATTGGTAGAAAATAATGTCGATTTCCCATCTAATGCTAGGAAAAAT
GCGCTGGTGGGGCTGTTCGATGAAAAGGTTAAACCGCAGATCCCGCAGTTACGGAAAATG
TATCTGAACGTTCGGCCCAGCGATGAAGGTATTGTGAAAATGGACCGTCCCTCATCTTCC
CCATCTATAGCTTCCCCTCGTAGAAGTAGACGAGCTCGCAGGGAGAAATCTGCTTCCCCC
ATGGCCAAACAGTTTAAGAAGAATAGAATACTGGATGATGTAAGTAATGATGATGATGAT
GATGATGATGATGATGATGACAATGATAAAAAAGACGATCCTTTAATTGTACCTAGTGGA
ACGGATACCGATGAAGTGGACGATGAAGAGGATGATGTGATAACATCAAGCTCCAACAAA
TCAGACACCAATGATTTCCAGCAAAATTCCGATACTCGTAAGAAAAGGAAAGACCCTGAT
TCTGACGACTGGTCTGAATCTAATTCAAAGGAAAATAAAATCGATAATAAGCATTTGAAC
CTCCTATCATCAGATTCAGAAATTGAACAGGATTACCAGAAGGCAAAAAAGCGTAAGACG
AGTGATTTGAACCAAGAGCATGGAAATGGCTCTGCCATTTTAGGAAAACTTTCCGTCAAA
ACACCAATAAAGAACACAAATAGAAAGCCAGTAAGCATGGATAATTTTAACGATTCGTTG
ACTTCAAGCGGTACGGAAAATGATCCATTTGTACCGAACATACGACACAATCCAAAAGAG
CTCGGAACTGCCAATGGAACAGGCCATAGCACACCCTTGAGTAAGTTAAAAGTTTCTGCC
TCATTTGCGGATAAATTGCCTCAAAAGGAGGTACCATCTACAATACTGGTTCCAGAAGTG
GAACAGCAAGAACCTTCTCAGAGTGAAAGAACACCGTCTTTGTTTTCGTCCGAAGGCTCT
GGCTCAGAGTCGGAAGCACCCTTGCTTCCAGAGATCACCACGCCAGGTCCTCATCAGCCT
ATGGGTAATACCAGCAATAATGTGGTCGAAATGATAGATACAGATAGTAGTAACTTGGTA
TCGGATGAAGATGAAGTTTTAGTGCCTACAAGGATCGAGACTCCCCAATTACCCACAGAG
AAAGACGTCGAAAAGTGTGAAGCAAGAGTGCAAGAACTTCAAGAGGAAGTAAATGAGCAA
TTAGAGCATGAAAATGGGAGTGAATTTGATGTTAAGCAAGGATCTGGGAAGGTCGGGAAC
AGGCATAAGTTCAAAAGAGCACTCAAATTTTTGAGCAAATCATTACTGGCGCTATTTTTA
TTTTGCATATTCATTGTTATTCCTCTCTTATTTGGCCTCTGGTATAGAGAGCAAAGACTG
CTCATAGGTTACTGTGGGCATGAAGTACCATCCCATCGAGTTAGTGGCAATTCCTTCGAG
TTTATTCAAAAACTGGATAATTTGTTGCAGGACTACAGACCGAAATGTATCCCTTGTCCA
CCCAATGGTATTTGTTATCCTTATTTGAAACTTAAATGTAAGCCAGATTACAAGTTAGCA
CCATCTAGACTTGACTTTTTGGAAATTATTCCTGCACAAGGCAAATGTGTTAAAGACGAC
AAAAAACAGCAGTTAGTTTCCGAAGTGGTTGAAAAATCTTTAGAGTTTCTGAGAGCCAAA
AATGCACAAATTTCATGCGGTGACGGAAAAGACGACATCGAGAGTGGTATGACGGAAGAT
GCCCTCTATCAAATATTTAATGAGGCTAGAGCTCCTTGGATTCGCGACGATGAATTTGAG
GACCTGTGGATCCAAGTTATCAAAGATTTAACTGAAGAACCAGAAATATTATGGAGGCAA
TTATCACCCACTGACAACAACATTGGCGGAAATTCCAACAACATCATTAAAACCAATGAC
GTTCCGAGACAGAAGAGACATCTTCCAGAAAAATTCATCTCCAAGACGAGGAATTTTCGG
TCGACGTCCAAGAAATACATTGGAATGAAGTGTCGATTTGAAAGAGAAATCTACCAAACG
TATAAAAAATTTCAAAGGCCAATATGGCTAATGTTTTTACTGATAGTCATTAGTAAAGTA
ATCGAGATCAAGCTGAAGAATTATTATAGAAAGAAGGCAAGAATTGAAGAACTCGTTACT
CAAACCATGGAAAAATTGAAATTCCAAAAGATTAAATCAATGTCCGATCCGAAAGAAAAC
GCGTATTTGAGCATAGTTCAATTGCGTGACATCTTTCTTTCTGATATTGTCGATCTGAAA
TACAAAAATCAATTATGGTCAGAAGTGGTAAAATATTTAGAGCATAATAACAGTAATATT
AAATCGAACTTAACTGAAATTCGAGGTGAAATAATGAAATGTTGGGAATGGATAGGTCCG
ATGGAACTCAATGAACCTAAGGATTCCGCTGAAAACAAAATATAA
Promoter Sequence
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>SRC1 YML034W
GTTGGAAGAGCTACAATTGGTAGAATGCGATGGTTGCTCCAAGATGGCAGAGTGAGAATC
ATGCTCATCTAGGGCCAACTGTTTGGTGCCATTTTCCAACAACTGCTGATTCTCGTGATA
CGAGAAATTAGCATTCCGAGAATCAGCAGCTAAACTTTCGTGTGAATCTTGCTGCTCTAA
GGGGGGTGTCTCATCATCCACTACGACACCAGCTTGTTCATCACCAATCTTTCTTTGATC
TATGTCAATGACTAGTCCTGAACCATCTTGTTCATCGTGTGAAGGAGCTGGTTCTAGAGA
AAGGTCGTTAAGCCTCTGTGTAGCCTGATTGTCCATAATTTTTTTTAGAATGCCCCCTTT
TTATTTGTTATATAATTTATTAATCTGGCGTACTAGCAGTTCAATCGAGTTTTGCTGAAT
CAAAATTGGCTATAGCAGGGAGACTATAATAAAAATACTATTAATATCCGATAATTGACT
AGTATACGAGAAACGCTGCTAATTCTGCCTGTAGAGAGAGAGAAGAAAAGTCGTCAAGAG
ATGCCTTTTTTTTTTTTTTAAAATTTATCTATTTTTTGATAATATCCTTTAAACCTTGTG
CTACTAGAACTCCTTTCTCATCATCGCCAGGCGCAAAAAAAAGATGAAAAAGGAATGAAA
AAAGAAAAGAGAAGACCCCCACGTGCCCTAAAAATAAAGTTAGGGCATCTATAAAATAAC
TAGGATATATATATTGATCACCCTGAACGGAAATCAAGGGTTTTAAAGAGCCCTCAAAAT
TACTGTTTTAGGAAGCCCCCTTTGTTTTTGTTTTGGTTTCAATTTGTGGTGGCTAATCTG
GACATCGATCTACTTGTATAGCTGTCAATATACTATGCGGAATACATGGAAGAGAAATAG
TCCTCAGTCATTATTAATAGTAGACTGAGACCATACGGAGTGAACGTAGAGGCCAGAACA
ACAAACAGTAGAACGGTAGCAGTACTCAGTTAGTGCCGCG
Chr coordinates
Chr XIII from 209525-211444,211571-212155