Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Standard Name
HMG1 Systematic Name
YML075C Strain
S288c Description
HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA View Seq
Sequence hidden Promoter Sequence
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>HMG1 YML075C
CGGCAAAAAAAGCGTTATCTTCTTTCTGTTCCTATTTCACTGAGTGCTACTGGATGGTCG
TCAAGAAAGGTGAAGAAATCTTCAAAGCAATAAGAATTCAGACATTGACGTTAAATTAGA
TTATCGCCGCAGCTGTAATTGCGGTTATGGCCTCTAGTATTTAGTTCGATGTTAATGAAA
TAAAGCGCAAGCTGACTGTGAACGATAACCGCCAGGAAGGCTAGACACAGCTCTTCAGCT
AAACAGTAGCCGGAACACATATACATTAGGGAACATTAGAAATAAGGCTCTCGTTGATCA
TCCTTGTAACTGAAAATTAGAACCGTTAAACGCTGCTGATTGATGGATTCCAGCCGTTCT
CTTCCAACCCCTTTTACCCCGATTGTTCGTCCACTATCATGACTTATTATCCACTAAAGT
GGCGTTGGCTGTACATTCGGGTGATGGTAGTATGGTGAGCACATGCTTTAAGTCCGAGAA
ACTAAGCTACAAAACGGAATTTCAAAGGGCCCCATTTTTATCGGGTGGACTAAGGGAAAG
AAAAGCCTTCTGGAGAAGAGTTGGAAGACCTCAGCGTAGTGCGAAGAAAACGTAGTGCGA
GTCTCTACGCCCGCTCGTTTAAAACTCTATAGAACGTCCGAAAGAAAGGTCCGTACTAGC
TATAGGATCTCTACTTTACCTATTATTATCGCTAGGTGATAGCTTATAAAACAATTCATC
GGTTTCTTCCTCATTTTTCCTGTATCTTTTCGGCTATGAAAAGCTGTTGTTCGATAAATC
CAGGCAAAGATTTTTGAAAGTTTAAAAGATCTAATTTTCAAAGGCATTCCTTTAAAAAAG
ACAACTTGAAAGAGCTATATTCGTCTTCGGTTTTTTGATTTTTATTAACTTATTTTTTTC
TTCTTTCTACCCAATTCTAGTCAGGAAAAGACTAAGGGCTGGAACATAGTGTATCATTGT
CTAATTGTTGATACAAAGTAGATAAATACATAAAACAAGC
Chr coordinates
Chr XIII from 118898-115734
