Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name ERO1
Systematic Name YML130C
Strain S288c
Description Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L
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Gene Sequence
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Promoter Sequence
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>ERO1 YML130C
TTACTGCCATTATGTAGGCCTTTTGAGTCAGCTTTGTGAAGAGATCTTATTACCTTAATT
CTTGCTGAAAAATACATCGCAATGAAGTCACTTTCGTGATGGAAAGAACACGGCGGTAAG
AATACGTTCCTTTTTGTGCTGTGTACACCCGTAAAATTGTACATTATTTATTTCAAAATA
TATAACAGGATCCCTCCAGTGTGTCTGAAATGATGCAACTCTGATACTTCAGAGTCGTAC
CCTTATTAAATACTAATGCCGAATATAGTCATCCAGTAGCCATAGTTCACACACACATTA
CTTATTCACCACATAAAGAACTAGAAATGCTTGCTAAATATCGTACCTTGAAGGTAAACA
TTAAGGCCCCCCAAAAGCATATATACATACTGGCAACACAAAAAAAGTAAATTGCCAACC
ACCTACCTTACATATGGTTTGCCCATCCTACATTACCAATACTATCAAGACATTTCTTCT
GAAACATATTCACAACTGAAACGAGATCATTTTCTTATCTATCTATTGAGTAATGCTTAC
TTTTCATATTTTCAATGAACAATAGGATATGTAGGAGAATTGATATATTCACTGCGTATC
AGAGAAAAGGTCTACTGACATTTTATGGCAAATGTATTCTACACAAATCGAGAATACCAC
AGACAATGGTACAAGACATACACAAAGAGAAGACTGTTCTAATTAAACAAATAATATTGA
GCTACCTGCTAAGTATGTCCTTTTCCCTTTGTCCTTTGGTTTCTCTTATAGAAGACCCTG
GAAATTTTTCGCATTTTTCCGGCTTTGGGCGTTAGTAAGAACAAAAAGAAAAGAAGAGAA
CAAAAAAGAAACGATACGGAGTACGTGTCATAAAAACTTGTTCAATCATCCTTGAAGCTA
AGTATAAAGAGCTTGAAAAGGTTTACCACTTAAACTGGTTATACTATTTCAAGAGTGTAA
ACATTTTATTGCATATACCACAGTAACGTGCAGGTAAAAC
Chr coordinates Chr XIII from 13174-11483
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