Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
MLH1
Systematic Name
YMR167W
Alias
PMS2
Strain
S288c
Description
Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; required for silencing at the silent mating-type loci and telomeres; human homolog is associated with hereditary non-polyposis colon cancer
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>MLH1 YMR167W
ATGTCTCTCAGAATAAAAGCACTTGATGCATCAGTGGTTAACAAAATTGCTGCAGGTGAG
ATCATAATATCCCCCGTAAATGCTCTCAAAGAAATGATGGAGAATTCCATCGATGCGAAT
GCTACAATGATTGATATTCTAGTCAAGGAAGGAGGAATTAAGGTACTTCAAATAACAGAT
AACGGATCTGGAATTAATAAAGCAGACCTGCCAATCTTATGTGAGCGATTCACGACGTCC
AAATTACAAAAATTCGAAGATTTGAGTCAGATTCAAACGTATGGATTCCGAGGAGAAGCT
TTAGCCAGTATCTCACATGTGGCAAGAGTCACAGTAACGACAAAAGTTAAAGAAGACAGA
TGTGCATGGAGAGTTTCATATGCAGAAGGTAAGATGTTGGAAAGCCCCAAACCTGTTGCT
GGAAAAGACGGTACCACGATCCTAGTTGAAGACCTTTTTTTCAATATTCCTTCTAGATTA
AGGGCCTTGAGGTCCCATAATGATGAATACTCTAAAATATTAGATGTTGTCGGGCGATAC
GCCATTCATTCCAAGGACATTGGCTTTTCTTGTAAAAAGTTCGGAGACTCTAATTATTCT
TTATCAGTTAAACCTTCATATACCGTCCAGGATAGGATTAGGACTGTGTTCAATAAATCT
GTGGCTTCGAATTTAATTACTTTTCATATCAGCAAAGTAGAAGATTTAAACCTGGAAAGC
GTTGATGGAAAGGTGTGTAATTTGAATTTCATATCCAAAAAGTCCATTTCACCAATTTTT
TTCATTAATAATAGACTAGTGACATGTGATCTTCTAAGAAGAGCTTTGAACAGCGTTTAC
TCCAATTATCTGCCAAAGGGCAACAGACCTTTTATTTATTTGGGAATTGTTATAGATCCG
GCGGCTGTTGATGTTAACGTTCACCCGACAAAGAGAGAGGTTCGTTTCCTGAGCCAAGAT
GAGATCATAGAGAAAATCGCCAATCAATTGCACGCCGAATTATCTGCCATTGATACTTCA
CGTACTTTCAAGGCTTCTTCAATTTCAACAAACAAGCCAGAGTCATTGATACCATTTAAT
GACACCATAGAAAGTGATAGGAATAGGAAGAGTCTCCGACAAGCCCAAGTGGTAGAGAAT
TCATATACGACAGCCAATAGTCAACTAAGGAAAGCGAAAAGACAAGAGAATAAACTAGTC
AGAATAGATGCTTCACAAGCTAAAATTACGTCATTTTTATCCTCAAGTCAACAGTTCAAC
TTTGAAGGATCGTCTACAAAGCGACAACTGAGTGAACCCAAGGTAACAAATGTAAGCCAC
TCCCAAGAGGCAGAAAAGCTGACACTAAATGAAAGCGAACAACCGCGTGATGCCAATACA
ATCAATGATAATGACTTGAAGGATCAACCTAAGAAGAAACAAAAGTTGGGGGATTATAAA
GTTCCAAGCATTGCCGATGACGAAAAGAATGCACTCCCGATTTCAAAAGACGGGTATATT
AGAGTACCTAAGGAGCGAGTTAATGTTAATCTTACGAGTATCAAGAAATTGCGTGAAAAA
GTAGATGATTCGATACATCGAGAACTAACAGACATTTTTGCAAATTTGAATTACGTTGGG
GTTGTAGATGAGGAAAGAAGATTAGCCGCTATTCAGCATGACTTAAAGCTTTTTTTAATA
GATTACGGATCTGTGTGCTATGAGCTATTCTATCAGATTGGTTTGACAGACTTCGCAAAC
TTTGGTAAGATAAACCTACAGAGTACAAATGTGTCAGATGATATAGTTTTGTATAATCTC
CTATCAGAATTTGACGAGTTAAATGACGATGCTTCCAAAGAAAAAATAATTAGTAAAATA
TGGGACATGAGCAGTATGCTAAATGAGTACTATTCCATAGAATTGGTGAATGATGGTCTA
GATAATGACTTAAAGTCTGTGAAGCTAAAATCTCTACCACTACTTTTAAAAGGCTACATT
CCATCTCTGGTCAAGTTACCATTTTTTATATATCGCCTGGGTAAAGAAGTTGATTGGGAG
GATGAACAAGAGTGTCTAGATGGTATTTTAAGAGAGATTGCATTACTCTATATACCTGAT
ATGGTTCCGAAAGTCGATACATCTGATGCATCGTTGTCAGAAGACGAAAAAGCCCAGTTT
ATAAATAGAAAGGAACACATATCCTCATTACTAGAACACGTTCTCTTCCCTTGTATCAAA
CGAAGGTTCCTGGCCCCTAGACACATTCTCAAGGATGTCGTGGAAATAGCCAACCTTCCA
GATCTATACAAAGTTTTTGAGAGGTGTTAA
Promoter Sequence
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>MLH1 YMR167W
TAAATTCGAATAATTATAGCCAGATTGAAAGAAAGGATTATTGAACCTTCCTTGCAATTG
TAGCCTTGTCTTTAGGACCTCTGATGGAACATAAACAAAACTGGAGATAAAATCGCCAAG
AAATCCAGCGCTCAAATGTGTGATGGTATCGTTAATCTGCCAATCTTCTATCATTGTTCT
CTTAGTATATTCATAGGTCCCAAAGAAGATTGCCGCTGACGGGAAGGAGCCTAACATGGC
AGCCATGTAACCGCCGTATAGCCCCCTTCTCACGCCTTCTTCTAGCCAAATGGTACGATA
TGCAGAGATCATGTTCCTGTATTTTTTGACATTGGGTGCGCCCTGTTGTCTTGTCTTAAC
AGTATCCAATGAATGCATCGCAGAATCTCCTATTTTTCCACCAATCCCACCGGAGACGAC
ACAATGCCATATAGGGCTTAAGTCCTCATCTGAATCGCCTCTTTTTTTGTGCAGTTTATC
ATCTTTTCGGTTATTATTTGGTTGATCTGGAGTTCCTTCTGATGTCGGGGGATGGTCATG
AGGCGTATGTATTATCGGTATTGAAGAACTCAGGTTCCATGAGTTCATTATCTTTTATAC
CAGTCGGTTGGAAGTGAAGATTATTATGCGTGCTTCGTTAGAATACTCAGCGTTTGTTTT
CGGCTTGCTTTGATGTTTTTTCAAATTAATGAACACAATGTAAGAAGTCGCTATCGTTGT
AGGGTCCTAGAGATGTCAAGTTAGAGTTCAATCGCAAGAAAAATAGGAATGTGATACCTT
CTATTGCATGCAAAGATAGTGTAGGAGGCGCTGCTATTGCCAAAGACTTTTGAGACCGCT
TGCTGTTTCATTATAGTTGAGGAGTTCTCGAAGACGAGAAATTAGCAGTTTTCGGTGTTT
AGTAATCGCGCTAGCATGCTAGGACAATTTAACTGCAAAATTTTGATACGATAGTGATAG
TAAATGGAAGGTAAAAATAACATAGACCTATCAATAAGCA
Chr coordinates
Chr XIII from 594886-597195