Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name TRM732
Systematic Name YMR259C
Strain S288c
Description Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; yeast null mutant can be functionally complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type 2 diabetes, and polycystic ovary syndrome (PCOS)
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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>TRM732 YMR259C
ATGACTACGGATGTGCAATTTTCAAGTCAGGAAATCGAGCTTTTCCGTGTCAAAGAATTC
TTGATTGCTAATAATCCAGCAAAGATCAACAATGAAAATAAGGATGCTGTTTTAACTCAG
ATTGAGCATGATTTCAGGTATTTAATACAGTATATCAAGGACGGATTACCGAACTTAAAT
GAGTCCACAAGGTTAATTTTTCCAGATACCTTTTCGATCTGTTTACTAAGGAGCCATCAA
ATAATTGCAAGCAAAAAAATTGACTCTCAAGAATTTTTATCGGCGGTAAAAGAGCAACTC
TTAACTGAAGCGAATGCAAATATTATCTTTGAATATGTTCTTGACTTTTGGGCTGATGGT
GGAGCCCCACTGATGAATGCCTTGAGAGATTTATTCAGTAAACTACTGAACTTATTGAAA
ATCACATATCCTATGTCAACCTTGAAGGATGTTTTATTTAATTGGATGAATGAAATATTA
GAAGTACCATCTACGTTGCGTGTTCAGTATTACTTGATTGATGCCCTTTCTTCTGATTTT
GACCTTTATTATATTATAGAAAAAAAGCCTCATTTCATCGATAACTCTTTTTCATTAATG
AACTCTGATTTGCTAGCAAATTCGGTAGGTAAATGCATTGTTAGTTTGCTGTTAAACATT
TACGAAAAGCATTTCAAAAAGAACGAGTCTTTTGTACAAGAATGGATACAATTATGGAAA
AGTTGTGCTTTAAAGTACATTCACGACAAACAATACACCAAATCCATTAATCTGTATATT
ATGATTCCATTATTCAAAAATATGCCAAACTCGGCCTTCACACTTTTCCTAGAATGTATG
TCTAACAAAGACCCATCACTTTTGCTCTCACTTTTAAAGATTGGCCAAGAATTGGGGATT
GAAGAAGAACCATTTTGTGATAATAAATATACCACTGTAGATTCTGTTAACAAACTCATA
GAGCAAGATGAGTATAAACTTCAGGTATTTGAAATACTGACCTTTTCGACAAAAAAGTCA
AAGCCTATTCGTCCCTTCGTCTTCAAAACTATAAAACAGTACCTATATGTGTTCTTCGTG
GACACTGAACTTGAACGCAGAAATTACTTTTGCAGTTCGATGAAACACTTTATATTTAGA
ACCAGAGACTGCGCATACTCTTTAGCTAGGGATGCCAGAAAGCTTAAAAAGGCTGAGAAA
TTTCCGGACGAACAGAGGGAAAAGTTGGCGCAAGTTGAGGAGGCTAGAGCCTTTTTGGTT
TGGCTATGCAATTTTATAAAATATAATTTGGCCCCTGGTACTTTATATCAGGCGAACGTG
ACCTCATTAAAACTTATGCACATTCTGATCAAGTCTGGTGTTGATAAATCTACTCCACAA
AAATTTTTAGACAACCAAAATAAGAGGGAATATCCTTTTTCTATCCCAATTTTACAGGAT
GTCACATTTTTAAGGTTGCTCATTGACCTTTTGGTTAGTAATTATGCTGACGTGCGCGAA
TTATCTAAAGAAATGCTATTTATAATGATAAGCGCTGATGAATCTAGAGGTCTTTTTTTG
GATACCTTAGACGCAAATGCTTTGAAGTGGACTGCAACCTCTCTTTTAAGTGACTATGAG
AAAGGTGATGCTGGAGCTACCGTATATGAGTTCATATTCACAGTCATGGGCTCTCAAAGA
AGCTTCATTGACCAGACAATTGATATATTAGCGCAGATGGTACAAAATTTGCAAAATGAC
AGCATTGGTTGTGCAGAAAATTCAATCGGTCCTCACTTTGCTGCACTAAGCTTGATTTTG
AATAAGTTTAACTCTGAAGAAAACCATCAAGATACTTCAAAAATAATCTCAAAATTAATA
AATCTTGTACTCAAGAGCTGGGAAGCAACGAGAAATGTAGTGTGTCATGATTCTGCCCAT
GGAATACTACCTGAAAAATATGCTAATTGTGGTGTACCGGACCAAGTTATAATAAGTCAC
GCATTTAGGGCGATAAAAGAAGCATCATATTTACTTGAAACAATATTAAAAAAATACCCT
TTAACAAGAGATCAATTAGACAGTATCGGCGATCTTTTTATTGTTCAGCTTTCTACTATT
CGTCATAGTGGCGCCTTCCAAGCCGTTTTACCGGGGCTAAAGGCATTTTGTATTCGTTGT
CAACTTGAATTTCCCGCTATTCTGGAAGAACTTTTAAGCAAGAGTGTAAAATCTTTAAAA
TCCAAAACTCAACATATTACAAGAAGGTCAGGAGGCTTGCCTTTCTTGGTCACAACCGTC
TTAAGTGCAGAAGTTACCAAAGGGAGACCTTTGTTACAAAAAACTTTTGAAAACTTACTA
CTCGTTGCAAGGTTACCAATTCCTCCCCATCAAGATGAGTTTGATTTACCACAGGTTAAT
GCTATTAATTGTATAAACGCAATCTTTGTTGAACCGAAGCTCTCTGTACACTGTACGTCA
TTTGTCTCAGAGGCATTAGAACTAGCTTTATTGAATTTCGACTGTGATATATGGGCTCTA
AGAAACTGTTCTATCATGCTGTTTACCTCCTTGCAAAATAGAATTTTTGGAAAAGTGGGC
AGAAGCGTTAGTGCAAAATTATTCTTTACCAAATATTCTGGCTTGAGGCAACTGCTTTTG
AATATTCTAAACAGTTCTATTGCTCAATATTCGGGAAGTGAAAGAAAATCATATCAAATT
GAAAGCATTTTCTTGGTCCTTAATGTGCTACTGAGGTTACGGCCTACAGCTGGCTATACT
GGTCTAAAAGAATTCAACGTTTCTGTTTATGAATGTTTATCAAATGAGAACTGGAAGATC
AGAGATATGGCCTCTAGAGTATTGCATATGCTGTCGGAAAATTTTGAAGAAGAGATAAGA
AAATTACTTGACTTGGCTTCTATCGCGAAGCAAAACCAGTTACATGGACACTTACTAGCA
CTCCAACAACTAGTACCACAATACCTTTCAGGAACTAGAGATATGGAGTTGATTCAAAGG
ATACTTGAAAAGAAAAGGATGCTTCTACTAGAGAACAAGTGCTTTATCACTAAAAAGGCC
TACTTAAAATTGACCTGCTGTATATTGGAAACATGCGACATACCTGATTCTATTTTAAAA
GATTATATCAGCACTTTGCGGAACACATTTATTGCTGAAAATAACGAATATGTTGTGGAT
GGTAGCAAACAGCTATATCTTGCACAAATCTTAGACATGCTCTTAAAATATGAGGATAGT
ATATATCTCGATGATATTTGCTTATTAGGATTGTATTCTCCATTTTATGAGGCTCAGCTC
AGTACACTACAGTACATGAATACTAACTTTCACTGGGAAACTACAAGAAACTCAGAATTT
CTTGAACAACTACAATTATTACTCAGGGTTCCAGATTTGCTGCCTATGGCTAAAGCTTTA
GTAGTGAAAATTCTCTCAAGAAAAAAGAATACTTTATCCCTGACGACCTGCACTGATCTC
CTAAAAACAAATAATAGTGAAGATACAAAACTTGCTGCCGTTTCATCACTAAGTGCTAAA
TTGTCTTCGCAAACCTTTCACCAGGTATGGAACTTGTTACAAGGATTTTTCGCCGATTCT
TGTTCAAAAGATTTTAGATTGGCATCTTTAGAATGTTTAACTGCTTATCCAGAAAGTTGT
AAGAACTCCAGAATACTATTACAACTGTACAACTTCTTATGGGACGATGATTCTGAAATA
AGAGAAAAGGCTTCTTTTTATTTGAATAAGAACTTTATTCAAACTGCAGACTGGGAATAT
AACAGGAACACCAGTGTGACCGCTCTTATATTCACAAAAAAGTTTGTTGACGTATTCACA
AGTTCTGAGGTGGTAGAAGAGTTGTGTTTACAGTTGTTTCAATATCTAAATGAATATGAT
ATGTTTGCTGCCGAAGAATCGGCGAAGAATTGTCTATTTACTATAGAAAAGGATAACCAG
TTCATCAACGAACTACAAAAGGCAATGCATATATTAAATATGATAAAATTGACTGGAAGG
GATATCTCAAAGTGTTACAAAGACCAGATACATCACCTAAAAAGTGCTCTATTGGAGCAC
TTCAACACCGAGGATTTTAAAGATTCCCCACTCGGCTGGTGCTCTAATGCTGAAATATTT
TCAAGAATAACGCTTTTAAAGGAACTGATTCAACATTATTCTCCTTCTGATTATGAGAAT
TTTATCAATGTTCTGACTAAACATTCTGTTCATCCCCTAATTATCAGTTATTCCCAATTA
TAA
Promoter Sequence
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>TRM732 YMR259C
GTGTACTTGCAAAAGCACTAGTGTAATATAGAGCAAAGTTCATCATGGGTAAGAAAAACA
CTAAAGGTGGTAAAAAAGGTAGAAGAGGTAAGAACGACTCTGACGGTCCAAAGCGTGAAC
TTATTTATAAGGAAGAAGGCCAAGAATATGCTCAAATCACCAAGATGTTGGGTAATGGAA
GAGTCGAAGCCAGTTGCTTTGATGGTAATAAGAGAATGGCCCATATTAGAGGTAAGTTAA
GAAAGAAAGTCTGGATGGGACAAGGTGATATTATTCTTGTTTCCTTAAGAGATTTCCAAG
ATGACCAATGTGATGTTGTCCACAAATATAATTTAGATGAAGCCAGAACACTGAAAAACC
AAGGTGAACTTCCTGAAAACGCCAAAATTAATGAAACAGACAACTTTGGTTTCGAATCTG
ATGAAGACGTTAACTTTGAATTTGGTAACGCTGATGAAGATGATGAGGAAGGTGAAGATG
AAGAACTTGATATTGATGACATTTAATTTAGGCCGAACAAGTGTCCTCAATATCTTCTAA
TGCGTCAACTATTCATAATTTATTTATAATTATATTTTTTAGTCCATCATAGGAAAGGGT
TTTCTTTTTACTATATCGAAATACTTATATATAGATATCAAAAAAAGAATAAAAATGAAA
TACCTCAAGAAGTCGTTTAATCTTCCTTCTAGGGTTTCTTTCAAGCGGACGTTAAGGAGA
CGTAATAAAAATTTTCTCGCACGAGAAATTTGAGCAAAGAGCACGTTGCGAATACGTTTT
ATCCATTCATCGTTTTTAATTTATTACCTTTTCTTTCGATGCTGTTTATTGTCACTCATG
AGTGCTTCCGTTTTTTCCATCGAAAATTTACTTTTTTAGACTGAAAAGAAAATGAAAAGT
TAAAATAAATTTTTACCAGAAAATGCTCATCGCAGGAAAATGACAATACTATTGTGAGCT
TCCCGAGGTACACATTACTTCATACTGAAAGTTTCAAAAA
Chr coordinates Chr XIII from 788883-784621
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