Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
SIS1 Systematic Name
YNL007C Strain
S288c Description
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1 External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>SIS1 YNL007C
ATGGTCAAGGAGACAAAACTTTATGATTTACTTGGAGTATCTCCAAGTGCTAATGAGCAA
GAACTGAAAAAGGGTTATAGAAAAGCAGCTCTAAAATATCATCCAGATAAGCCAACAGGT
GACACAGAAAAGTTTAAGGAGATATCAGAGGCCTTTGAAATTTTAAATGATCCTCAAAAA
AGGGAAATATATGATCAATACGGTCTCGAGGCTGCTAGATCTGGTGGTCCAAGCTTTGGT
CCTGGTGGTCCTGGCGGTGCTGGAGGTGCTGGAGGCTTCCCTGGCGGTGCGGGCGGATTC
TCCGGAGGACATGCGTTCAGTAATGAGGATGCTTTCAATATTTTTTCACAATTCTTTGGC
GGCAGTTCCCCATTCGGTGGTGCTGATGACAGTGGCTTCAGTTTCTCTAGTTATCCATCT
GGCGGCGGTGCTGGTATGGGAGGTATGCCTGGAGGAATGGGAGGAATGCATGGCGGCATG
GGAGGTATGCCTGGCGGCTTTAGATCAGCATCAAGCTCTCCCACGTATCCAGAGGAAGAA
ACAGTTCAAGTTAATTTACCAGTTAGTCTAGAAGATTTGTTTGTTGGTAAAAAGAAGTCA
TTTAAAATTGGAAGAAAGGGCCCACATGGGGCCTCTGAAAAGACACAAATTGACATTCAA
TTAAAACCGGGTTGGAAAGCTGGTACCAAAATAACATACAAGAACCAGGGTGATTACAAT
CCTCAAACGGGCCGTAGAAAGACTTTGCAGTTTGTCATCCAGGAAAAGAGCCATCCAAAC
TTTAAAAGAGACGGTGATGACCTAATTTACACTCTGCCACTATCTTTCAAGGAATCATTG
TTAGGTTTTTCAAAAACTATCCAAACAATTGATGGCAGAACCTTACCTTTGTCGAGAGTA
CAGCCTGTCCAACCCTCACAAACTTCTACTTATCCTGGTCAAGGTATGCCAACTCCAAAG
AACCCATCTCAGAGAGGTAATTTGATTGTAAAATATAAAGTGGACTATCCAATATCACTA
AACGACGCTCAAAAACGTGCTATAGATGAAAATTTTTAA Promoter Sequence
Download FASTA
>SIS1 YNL007C
TAGATAAAGACTGGAGAGAGGTATCGTCCTCAGGTGTCAATTGATGGGTACACTGATTTT
CTCCTAAGTCCCAAATTCTTATATTACCATCTCTATCACAAGATATCAACTCGCCTTGGT
TAGGATGAATTACGACTTCATTTACTGGTGCGTTATGTTTGTAATTTCTAGGAATGGACG
GAGAACGCACATCCCAAACTTTAATGGTCCCATCTTCGCTAGAGGTCACCATCCATCTGT
TGTCCTGTTGAAAAGAAACGGAGGTAACGTTTCCCCGATGACCCTCAAAGGATGCTACTG
GATTGGGATTTGTCGTCCGAATGTCATAAAGCCGTACGTTTTGATGGCCTGCTGTTGCCA
ACAACTTTTTATCGTTGGTGATTTCTAAGCGATTAACCTGTGAGTCGGAATGCTGAATTG
TTCTTGAACAAACCCCAGTAAGAGCCTCCCAAAATCTTATTGTGTGGTCATAGCCAGCAG
ATACTAAGATAACAGACATCAATCAGAACTCCTTTTTTATATGGATGACAAGACTGCCAC
GTTGATCGCTGCGCTAATAATATATGGTTGTCGCACTCTTCTATAACATGATCAGTAATA
GCTAGTCGTTACTTTTCTGAATCTTAACGTATTGTGTTACCCTCTTTGGTTTATATGAAC
GTTCCAGAAACTTCTGGAAAAAGAATGGGATATCCTTTTACGGGTTTTTCAACCACTGTC
AGCACAAACTCCTTGCCAAGGTAGTTCGAGATTTAATATATATTGTATAGATTTCTCGTC
CCTTTACCGTATTGTTAATCCCTTTTTAAACTTATGCGCTTTCTTGTCAAAAATTCTAAT
TAATATTATTTAAGCTCTTACACGAATTCTTTTAACGACTTAGAATTGTATAACCATCCA
GAAACTCTTCAGAGGATAAAGGATAAGTTGTTTGCATTTTAAGATTTTTTTTTTAATACA
TTCACATCAATATAATAGAGTATAGTATACAGAACTAATA
Chr coordinates
Chr XIV from 619565-618507
