Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
TOP2 Systematic Name
YNL088W Alias
TOR3, TRF3 Strain
S288c Description
Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>TOP2 YNL088W
ATGTCAACTGAACCGGTAAGCGCCTCTGATAAATATCAGAAAATTTCTCAACTGGAACAT
ATCTTAAAAAGACCAGACACTTATATCGGTTCTGTTGAAACTCAAGAGCAGCTGCAATGG
ATATACGATGAAGAGACCGATTGCATGATTGAAAAAAATGTCACAATTGTACCAGGGTTG
TTCAAAATCTTTGATGAAATCTTAGTCAATGCGGCAGATAATAAAGTTCGTGATCCATCG
ATGAAACGAATCGATGTAAACATACATGCTGAGGAACATACTATAGAAGTGAAAAATGAT
GGAAAAGGTATTCCCATAGAGATTCATAACAAGGAGAATATTTATATTCCTGAAATGATA
TTTGGTCATTTGTTGACATCATCCAATTATGATGATGATGAGAAGAAAGTCACTGGTGGT
AGAAACGGTTATGGTGCTAAGCTTTGTAATATATTTTCCACTGAATTCATATTAGAAACT
GCAGATCTAAATGTTGGCCAGAAATATGTTCAAAAATGGGAAAATAACATGAGCATTTGC
CACCCCCCAAAAATAACATCTTACAAGAAGGGTCCATCATATACAAAGGTGACATTTAAG
CCGGATTTAACCAGATTCGGAATGAAAGAGCTAGATAATGATATCTTAGGAGTGATGCGA
AGAAGAGTTTATGATATCAATGGTTCTGTTCGTGACATTAATGTCTATCTGAATGGCAAG
TCCTTAAAGATAAGAAATTTCAAAAATTATGTTGAACTCTACTTGAAATCACTCGAAAAA
AAAAGACAACTAGATAACGGTGAGGACGGTGCCGCTAAGTCTGATATCCCGACTATTCTT
TATGAGAGAATAAACAACAGATGGGAAGTTGCTTTTGCGGTTTCTGATATCTCTTTTCAA
CAAATTTCTTTTGTGAATTCCATTGCAACTACCATGGGTGGTACCCATGTCAATTACATA
ACAGACCAAATTGTAAAAAAAATTTCAGAAATTTTGAAGAAAAAGAAGAAAAAAAGTGTG
AAGTCTTTTCAGATTAAAAATAATATGTTCATTTTCATTAATTGTTTGATTGAGAATCCT
GCATTTACCTCACAAACAAAAGAGCAACTGACAACAAGAGTCAAAGATTTTGGGTCCCGT
TGTGAGATTCCTCTTGAATATATTAATAAGATTATGAAAACTGATTTGGCTACAAGAATG
TTTGAAATTGCCGACGCAAATGAAGAAAATGCGCTAAAGAAGTCTGATGGTACAAGGAAA
AGCAGAATTACTAATTACCCTAAACTGGAAGATGCCAACAAAGCCGGTACAAAAGAAGGC
TATAAATGTACTTTAGTTCTGACAGAAGGGGATTCCGCCTTGTCATTAGCTGTTGCAGGT
TTAGCTGTTGTTGGTAGAGATTATTATGGTTGTTATCCACTTCGTGGTAAAATGCTGAAT
GTTAGAGAAGCTAGTGCTGATCAGATACTAAAAAACGCGGAAATTCAAGCCATTAAAAAA
ATTATGGGGTTACAACATCGCAAGAAATATGAAGATACAAAATCTTTAAGATATGGGCAT
CTTATGATCATGACCGATCAAGATCATGATGGTTCGCATATTAAAGGTTTAATTATAAAC
TTTTTAGAAAGCTCATTTCCTGGTCTTTTGGATATCCAAGGTTTCTTACTTGAATTCATA
ACTCCGATCATCAAAGTTTCCATCACTAAACCAACAAAAAACACTATTGCATTCTACAAT
ATGCCGGACTATGAAAAATGGAGAGAGGAAGAATCGCACAAATTTACTTGGAAGCAGAAG
TATTATAAAGGATTAGGGACTTCTCTAGCACAAGAAGTCCGAGAATATTTTTCGAACTTG
GACAGACATTTGAAAATATTCCATTCTTTGCAGGGTAATGATAAAGATTACATTGATTTA
GCTTTCTCCAAGAAAAAGGCAGATGACCGTAAAGAATGGCTGAGACAATACGAACCTGGT
ACTGTTTTAGACCCTACTTTAAAAGAGATTCCAATTAGCGACTTCATTAATAAGGAATTA
ATCCTTTTTTCTTTGGCCGATAATATACGGTCGATTCCCAATGTTTTAGATGGATTTAAA
CCTGGCCAAAGAAAAGTTCTTTATGGTTGTTTCAAAAAAAATTTAAAGTCGGAACTGAAA
GTAGCTCAACTTGCACCATACGTGAGCGAATGTACGGCATATCACCATGGTGAGCAGTCA
TTGGCACAAACTATTATTGGGCTAGCCCAAAACTTTGTTGGGTCCAACAATATTTACTTG
CTATTACCTAACGGTGCTTTCGGTACAAGAGCCACTGGTGGTAAAGATGCAGCGGCAGCG
AGATATATCTACACAGAATTGAACAAATTAACTCGTAAGATATTTCACCCTGCTGATGAT
CCATTATACAAATATATACAAGAAGATGAGAAAACAGTGGAGCCAGAGTGGTATTTACCA
ATTCTTCCTATGATTCTTGTTAACGGTGCTGAGGGTATTGGCACTGGCTGGAGTACTTAC
ATTCCTCCATTCAACCCATTGGAAATTATAAAGAATATAAGACATTTAATGAACGACGAG
GAGCTTGAGCAAATGCATCCGTGGTTTAGGGGATGGACCGGTACTATTGAAGAAATTGAG
CCTCTGCGTTACAGAATGTACGGTAGGATTGAACAAATTGGAGATAACGTCTTAGAAATA
ACTGAGTTGCCAGCCAGAACTTGGACATCGACTATAAAGGAGTACTTACTTTTAGGTTTA
AGCGGTAACGATAAAATAAAACCCTGGATCAAAGATATGGAGGAGCAGCACGATGATAAC
ATCAAATTCATAATCACGCTATCACCTGAGGAAATGGCTAAAACAAGGAAAATAGGTTTT
TATGAAAGATTTAAACTAATTTCGCCTATAAGTTTGATGAATATGGTCGCATTTGATCCT
CACGGGAAAATCAAGAAGTACAATTCCGTGAATGAAATATTAAGCGAATTTTACTACGTC
AGACTAGAATACTATCAAAAAAGAAAAGACCATATGAGCGAAAGGTTACAGTGGGAGGTA
GAGAAATACTCTTTCCAAGTAAAATTTATTAAAATGATTATTGAAAAGGAGTTAACAGTC
ACCAATAAGCCTAGGAACGCTATTATCCAAGAACTTGAGAATTTAGGGTTCCCCAGATTT
AATAAGGAAGGTAAACCATATTATGGAAGTCCTAACGATGAGATAGCTGAACAAATTAAC
GACGTAAAAGGCGCAACTTCTGATGAAGAAGATGAAGAAAGTTCACACGAAGATACTGAA
AATGTTATAAATGGTCCTGAAGAACTATATGGCACATATGAATATTTATTAGGAATGAGA
ATATGGTCATTGACCAAGGAAAGATATCAAAAGCTGTTGAAACAAAAACAAGAAAAGGAG
ACAGAGTTGGAAAACTTGTTAAAACTTTCCGCGAAAGATATATGGAACACTGACTTGAAG
GCTTTTGAGGTGGGATATCAAGAATTTTTGCAACGAGATGCAGAAGCTCGCGGTGGTAAT
GTTCCCAATAAAGGGAGCAAAACGAAAGGTAAAGGAAAAAGAAAGCTTGTTGACGACGAA
GACTACGACCCATCAAAAAAAAACAAGAAAAGTACTGCTAGAAAGGGCAAAAAAATTAAG
TTAGAGGATAAGAATTTTGAAAGGATTTTGTTAGAACAAAAACTAGTAACCAAAAGCAAG
GCGCCTACAAAGATTAAAAAAGAGAAAACGCCTTCTGTTTCAGAAACAAAAACAGAAGAA
GAAGAGAATGCTCCTTCTTCCACGAGTTCTTCTTCTATTTTCGACATAAAGAAAGAAGAT
AAAGATGAGGGCGAACTGAGTAAGATTTCGAACAAGTTTAAAAAAATTAGCACGATTTTT
GACAAAATGGGTTCTACTTCCGCTACATCGAAGGAAAATACACCAGAACAGGACGATGTA
GCCACTAAAAAAAATCAAACAACCGCTAAAAAAACAGCTGTAAAACCTAAATTGGCCAAG
AAGCCAGTCAGGAAACAACAAAAAGTTGTGGAACTATCTGGTGAAAGCGACCTAGAAATT
TTAGATTCATACACTGATCGGGAAGATAGCAATAAAGATGAAGATGATGCTATACCACAA
CGATCAAGGAGACAAAGATCGTCGAGAGCTGCGTCGGTTCCTAAGAAATCTTACGTTGAA
ACTTTAGAATTATCTGACGACAGTTTCATCGAAGATGATGAAGAGGAAAACCAAGGATCA
GATGTTTCGTTCAATGAAGAGGATTGA Promoter Sequence
Download FASTA
>TOP2 YNL088W
ATTGCAGAGTTGACGGAATAAAAGTGTCCTTAACGCTCTGGGATACAGCGGGACAAGAGG
AATATGAACGTTTACGTCCATTCTCATATTCAAAAGCAGATATAATATTAATTGGGTTTG
CTGTAGACAATTTTGAATCACTAATTAACGCAAGGACGAAATGGGCGGATGAGGCATTAC
GATATTGTCCTGACGCACCAATCGTTCTTGTAGGCTTGAAAAAAGATTTGAGGCAAGAAG
CCCATTTTAAAGAGAATGCTACCGATGAAATGGTTCCCATTGAAGATGCAAAACAAGTTG
CAAGGGCCATTGGGGCCAAGAAATACATGGAATGTAGTGCACTGACTGGTGAGGGTGTGG
ATGATGTCTTTGAAGTAGCTACAAGAACCAGTTTGCTTATGAAGAAGGAACCAGGGGCTA
ACTGTTGCATAATTTTATAAAAAAAACTTACACTGAAATGATACATTATCTTTTTAGCAA
GGGAGGGAAAAACAATACCGTATTATAATTTTAATCAAATTTCATAGATATAATGGAATA
AGTTAAAAAGGCTTATCGATAGTGCATGTATAAAACACAAACCCATTCGATATGTTTGTT
CGTTAATGTCCTACAGATTCTTATTCGAGAGCCTTTACCAGAAGCAAAATTTCCGACGGA
TATAAGAAAATGGCACATCAAACCATAGCTCAAGGTACTGCGCCGATGAGCTAAACGGAA
CTGCCTAGTTTGATTATTTTTCGTTTATATACTTATTTACTTATTTACGCTATTTGTATT
CGAATTCCTTACGAGGCGATGAGTGAAAGACGCGCCAGTAGGACGCGTCTTTTTTTTTTC
AGTATAATGTAAACATATTATTGAATTGCCGAAGGAGACAAAAAGAAAAGAAAAGAGGAG
ATCATCTTTCATATAATCCAACCACGTCGTAGAGCAAACCACGACAATTTTAACTTTCTG
TTTCAGTTAAAGGAGTTTATAACGACCAGCACGGCTAACC
Chr coordinates
Chr XIV from 457704-461990
