Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
TOP1 Systematic Name
YOL006C Alias
MAK1, MAK17 Strain
S288c Description
Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA View Seq
Sequence hidden Promoter Sequence
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>TOP1 YOL006C
GATAATGCTGCTATCCGAGTTCAAAAAACTTGCAAGCTCAATATTATCATTACCCGGACT
TAATAAAGTGGAAGTGTCCGCGAAAATTCTAGGTTCACTGCTTTGGCACACACAAGAGGT
CCGTTAAAAGAAGAGCGAGAGAACTGAGCCGTGCAGCCTAAATAGATAGCTACGTAGCCA
CCAAACCAGATACATTTGGACACAACTGCATCATGAATGCTCCAGACAGATTCGAACTGT
TCCTTCTGGGTGAAGGGGAATCCAAGCTAAAGATTGACCCCGACACCAAAGCCCCCAACG
CAGTAGTGATAACGTTTGAGAAGGAGGACCACACGTTGGGAAACCTGATTCGTGCAGAAC
TTCTGAACGACAGAAAAGTGCTGTTTGCCGCTTACAAGGTTGAGCATCCCTTCTTCGCTC
GTTTCAAGCTGAGAATACAGACCACCGAGGGCTACGACCCGAAGGATGCCTTGAAAAACG
CCTGTAACAGCATCATTAACAAGCTTGGCGCCCTGAAGACAAATTTCGAAACCGAGTGGA
ACCTGCAAACTCTAGCCGCCGACGACGCATTTTGATATATAGGAGTTTAATACTATAGCC
ATAAAATCTAAACAGAATGGAAACGGACATACACATAATATACGCTCATATATATTTATA
CATAACTTCAATGTCTTGAACACGTAAATTTTAGTGTGAGAAACCTTTTTCACTCCGGGT
AATACCTGCTGTAGTCTTCAAAAAAAAAAAAAAAAAAGAAAAAAAACCAGCCATGGAAAG
CTCTTTATTTTTTTACTTTACGGCTTTTTTCCCTTTTCTTATATGATCGATGCACGTAAA
GAACAACTGTATTTTTTTGTTTCAACACTAACACGAGCGCAATATTCTTTTTTGTTTTCT
CTGTTACTCTAATTACCTGAGTCCTATTCTTATAGTATTAAAACAGCAAATAAAAAAAAT
CTAAAGGGAGGGCAGAGCTCGAAACTTGAAACGCGTAAAA
Chr coordinates
Chr XV from 315387-313078
