Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
TOP1 Systematic Name
YOL006C Alias
MAK1, MAK17 Strain
S288c Description
Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>TOP1 YOL006C
ATGACTATTGCTGATGCTTCCAAAGTTAATCATGAGTTGTCTTCTGATGACGATGACGAT
GTGCCATTATCTCAAACTTTAAAAAAAAGAAAGGTGGCGTCCATGAACTCTGCCTCTCTT
CAAGACGAAGCGGAACCTTATGATAGTGATGAGGCAATCTCTAAGATTTCCAAGAAAAAG
ACTAAGAAAATAAAGACCGAACCAGTGCAATCGTCGTCATTACCATCGCCTCCAGCAAAG
AAAAGCGCGACATCAAAGCCTAAAAAAATCAAGAAAGAAGATGGTGATGTAAAGGTAAAA
ACAACTAAAAAGGAAGAACAGGAGAACGAAAAAAAGAAACGAGAAGAAGAAGAAGAGGAG
GACAAGAAAGCGAAGGAGGAGGAGGAAGAATATAAATGGTGGGAAAAAGAAAACGAAGAT
GACACCATAAAATGGGTCACACTGAAGCATAACGGTGTTATATTCCCTCCACCATACCAG
CCCTTACCATCTCACATCAAATTATATTACGATGGGAAGCCAGTAGATTTACCTCCGCAA
GCTGAAGAAGTAGCCGGGTTCTTTGCTGCCCTATTAGAGAGTGATCATGCCAAAAATCCT
GTTTTCCAAAAGAACTTCTTCAATGATTTCTTGCAAGTACTGAAAGAAAGTGGTGGTCCC
CTCAATGGAATTGAGATAAAGGAATTTTCTCGTTGCGATTTCACCAAAATGTTTGATTAC
TTCCAGTTACAAAAAGAACAGAAAAAGCAACTGACTTCCCAAGAAAAGAAACAGATTCGT
TTGGAAAGAGAAAAATTCGAGGAAGATTATAAATTCTGTGAATTAGATGGCAGAAGGGAA
CAAGTAGGGAATTTCAAGGTTGAACCTCCTGATCTATTTAGAGGTCGTGGCGCTCACCCA
AAAACAGGCAAATTGAAGAGAAGAGTGAATCCTGAGGATATCGTTTTAAATCTAAGTAAA
GACGCACCCGTTCCGCCAGCCCCAGAAGGGCACAAGTGGGGTGAAATCAGACACGACAAT
ACCGTTCAATGGTTAGCCATGTGGAGAGAGAATATTTTCAACTCATTCAAATACGTCAGA
TTGGCAGCGAACTCTTCATTGAAGGGTCAAAGTGACTACAAGAAGTTTGAAAAGGCGAGA
CAATTGAAATCCTATATCGATGCCATCAGAAGGGATTACACGAGAAATTTGAAAAGCAAA
GTTATGCTAGAGCGCCAAAAGGCCGTAGCCATTTATTTGATCGATGTATTCGCTTTAAGA
GCCGGTGGTGAAAAATCCGAAGATGAAGCCGATACTGTGGGTTGTTGTTCATTGCGATAT
GAGCATGTTACTTTGAAACCTCCGAATACTGTTATCTTTGATTTCTTAGGTAAGGATTCT
ATTAGATTTTATCAAGAGGTAGAAGTTGACAAACAAGTTTTCAAAAATTTGACAATTTTT
AAAAGGCCGCCCAAACAGCCAGGACATCAACTGTTTGATCGTCTAGATCCATCTATACTG
AACAAATATCTACAAAACTACATGCCGGGATTGACTGCTAAAGTTTTCCGTACATATAAT
GCTTCCAAAACAATGCAAGATCAACTGGATCTAATTCCAAATAAAGGATCTGTCGCAGAG
AAAATATTGAAGTACAACGCAGCAAATAGAACTGTAGCCATCCTATGTAACCATCAAAGG
ACTGTCACGAAGGGGCATGCACAAACAGTGGAAAAGGCCAATAATAGAATACAAGAGTTG
GAATGGCAAAAGATTCGTTGCAAGAGGGCCATTTTACAATTGGATAAGGATCTTTTAAAG
AAAGAGCCAAAATATTTCGAAGAAATCGACGATTTGACGAAAGAAGATGAAGCCACCATT
CACAAGAGAATTATTGATAGAGAAATTGAAAAATATCAGCGAAAATTTGTTAGGGAGAAC
GATAAGAGGAAATTTGAAAAGGAAGAATTATTGCCGGAAAGTCAATTGAAGGAATGGTTG
GAGAAAGTCGACGAAAAGAAACAAGAATTCGAAAAGGAATTGAAAACCGGTGAAGTGGAA
CTGAAATCAAGTTGGAATTCAGTCGAAAAAATAAAAGCACAAGTAGAGAAATTAGAACAG
CGTATCCAAACTAGTTCCATTCAGTTGAAAGATAAAGAGGAAAACTCCCAGGTTTCACTG
GGCACTTCCAAAATCAATTATATAGACCCTAGACTTTCTGTGGTATTTTGCAAAAAGTAT
GATGTTCCGATTGAAAAGATTTTTACAAAAACCCTAAGAGAAAAATTCAAATGGGCCATA
GAATCGGTAGATGAAAATTGGAGGTTTTAA Promoter Sequence
Download FASTA
>TOP1 YOL006C
GATAATGCTGCTATCCGAGTTCAAAAAACTTGCAAGCTCAATATTATCATTACCCGGACT
TAATAAAGTGGAAGTGTCCGCGAAAATTCTAGGTTCACTGCTTTGGCACACACAAGAGGT
CCGTTAAAAGAAGAGCGAGAGAACTGAGCCGTGCAGCCTAAATAGATAGCTACGTAGCCA
CCAAACCAGATACATTTGGACACAACTGCATCATGAATGCTCCAGACAGATTCGAACTGT
TCCTTCTGGGTGAAGGGGAATCCAAGCTAAAGATTGACCCCGACACCAAAGCCCCCAACG
CAGTAGTGATAACGTTTGAGAAGGAGGACCACACGTTGGGAAACCTGATTCGTGCAGAAC
TTCTGAACGACAGAAAAGTGCTGTTTGCCGCTTACAAGGTTGAGCATCCCTTCTTCGCTC
GTTTCAAGCTGAGAATACAGACCACCGAGGGCTACGACCCGAAGGATGCCTTGAAAAACG
CCTGTAACAGCATCATTAACAAGCTTGGCGCCCTGAAGACAAATTTCGAAACCGAGTGGA
ACCTGCAAACTCTAGCCGCCGACGACGCATTTTGATATATAGGAGTTTAATACTATAGCC
ATAAAATCTAAACAGAATGGAAACGGACATACACATAATATACGCTCATATATATTTATA
CATAACTTCAATGTCTTGAACACGTAAATTTTAGTGTGAGAAACCTTTTTCACTCCGGGT
AATACCTGCTGTAGTCTTCAAAAAAAAAAAAAAAAAAGAAAAAAAACCAGCCATGGAAAG
CTCTTTATTTTTTTACTTTACGGCTTTTTTCCCTTTTCTTATATGATCGATGCACGTAAA
GAACAACTGTATTTTTTTGTTTCAACACTAACACGAGCGCAATATTCTTTTTTGTTTTCT
CTGTTACTCTAATTACCTGAGTCCTATTCTTATAGTATTAAAACAGCAAATAAAAAAAAT
CTAAAGGGAGGGCAGAGCTCGAAACTTGAAACGCGTAAAA
Chr coordinates
Chr XV from 315387-313078
