Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
TCB1
Systematic Name
YOR086C
Alias
tricalbin
Strain
S288c
Description
Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; TCB1 has a paralog, TCB2, that arose from the whole genome duplication
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>TCB1 YOR086C
ATGGCCAAAGAAGATACTGGGGTAACAGCACCAAAGAAGCCCGAAACAGCCCAAGTAGCT
AACATAAATGGGATAGATAAGTTAGAACCTCCAAAGACGAAAGAGGAAACCGAATCCAGT
AAAAGCGTGTCATCTGAGAAGGCGGCACATGCTAGTGATGAAAGCTTCAAGAGAAGTATC
CATGAAGCTTCTTATGTCGGCTGGAAACAGATTGGTGGCTGGGAAGACAAAGACGAATTA
ACTTTAGATGATGAATTGATGGATATGACTAGAGAAACCTTCTTAGATAACATCATACCG
GACAGCCTTTACGGTGACTGGTATCATTCGGTAGCCATTTTCTTTATCGGAGGCGTGGCA
TCATTTGCACTTGGTCATTATAAGTTTTCAATGGGGTCGGCCTTTTTTGTCATCGTTATC
ACTTCATTGTTGTATAGAACCTCTGCTAAAAAATACAGAGGTTCCATAAGAGAGTTAGTC
CAGAAAGAGTTCACGGTGCAGAAAGTGGAAAACGACTATGAATCCCTAGAATGGTTGAAT
GCCTTTTTGGATAAGTACTGGCCCATTTTAGAACCTTCCGTTAGTCAATTAATCGTTCAG
CAAGCTAATGAACAAATGGCTACTAATGAGGCGATTCCCAAATTTATTACTCAACTATGG
ATCGATGAGTTGACACTTGGTGTTAAACCCCCCAGAGTTGATTTGGTGAAGACTTTCCAA
AACACTGCATCCGATGTTGTTGTGATGGACTGGGGTATTTCTTTTACTCCTCACGATTTA
TGCGACATGAGTGCTAAGCAAGTCAGAAATTACGTTAATGAATTAGCGGTTGTTAAGGCC
AAAATTTTTGGTATCACCATCCCTGTTTCTGTGTCAGACATTGCTTTCAAGGCTCATGCT
AGAGTGAAATTCAAATTGATGACTCCCTTCCCTCATGTCGAAACTGTTAATATCCAGCTA
CTGAAGGTTCCTGATTTTGATTTTGTTGCTACCTTATTCGGCCGTTCCATCTTCAATTGG
GAAATTTTAGCTATCCCAGGCCTTATGACACTAATACAAAAGATGGCCAAGAAATATATG
GGTCCAATCTTGTTACCTCCATTTTCTTTACAATTGAACATTCCACAACTCTTATCTGGT
TCCAACTTGTCCATTGGTATATTAGAAATAACTGTCAAAAATGCAAAGGGGCTAAAACGT
ACCTCTTCGATATTGAACGAATCAATCGACCCTTACTTATCTTTCGAATTTAACGATATA
TCTATTGCCAAGACAAGAACCGTAAGAGACACATTGAACCCCGTTTGGGACGAAACTCTG
TACGTCTTGTTAAACTCATTCACTGACCCCTTGACCATTAGTGTTTATGATAAGCGTGCA
AAATTGAAGGATAAAGTCCTAGGCAGAATTCAGTACAACTTGAATACTTTACATGATAAA
ACCACGCAAAGAAACTTGAAAGCTCAGTTTTTAAGAAACTCTAAACCGGTTGGGGAATTG
ACTTTTGATTTAAGATTCTTCCCAACTTTAGAAGAGAAAAAGTTGCCGGATGGATCTGTG
GAGGAACTACCGGATTTGAATACTGGTATTGCTAAAGTTGTGGTCGAAGAAGGTTCTCGT
TTTGCTGAAGAAGAACAGAAGGTTACTGCCTACGTTGAAGTTTACTTGAATGCTAAACTA
GTGTTAACCACTGGTAAGGCAACTGACACTGGTACATTGAAGTGGAATTCAGACTACGAA
GCAGTTATTGCAGATCGTCGTAAAACAAGATATAAGTTTGTCGTCAAGGATGGCAAAGGA
GAAGAAATTGGATCTACCATTCAAACCCTGAATGATTTAATAGATAGAAGCCAAGTGAAC
AAAAATTTGATTCCATTAAAAAACCAAAAGGGTGACATAAAGATTACCACATATTGGAGA
CCTGTTAGACTGGAGATTGGTTCCAACTCTGTAGCTTACACGCCACCAATTGGCGCCATC
AGAGTATTCATTGAGAAGGCAAACGATTTGAGAAATTTGGAAAAGTTTGGTACCATTGAT
CCATACTGTAAAGTTTTGGTTAATGGTTTATCGAAGGGTAGAACTGATTTCAAGAGCCAA
ACTTTGAATCCTGTCTGGAATCAAGTTATTTATGTTGCAGTTACTTCACCAAACCAAAGA
ATTACGCTTCAATGTATGGATGTCGAAACAGTCAACAAAGATCGTTCACTTGGTGAATTC
AATGTTAACGTTCAAGATTTATTTAAGAAGGATGAGAATGATAAATATGAGGAAACTATT
GATGAAAAAGCTAAAGTTGGTCGTCTAGTGATGCCTAAGAAAAAACCTAAGGGCACTATA
ACATACTATACCTCCTTTTATCCCGCTTTACCTGTTTTAACGTTAGAGGAAATCCAAGAT
TTAGATAAAGTTAACAAAAAGAAAAAAGCATTGGAACTGCGTAAGTCAGCAATTGATGAG
AAAAAAATTTCTAAAGAAGACAAAGCCAAATTTGATCAAGAATGGAATGAGGTCAAAGAA
TTGGAAGACATGTATAGTAATAGACAGAAATTGGATTTGCCAGAATTATTGCAATACAAC
CAAGGTGTTCTTGCTGTCACTGTCCTTAATGGGGAATTGCCCGACTCTGGGCTATACGTC
CAAGCGTTTTTCGATGATAATGGTCATCCAAGATTTGTTAGTCCACGTATTCCATCGAGA
ATTGTCAAGAATGGTTGGTCAGGTGACGTGATCATAAAAGAATTGGACAAATCCATTACC
ACTTTTAGAGTTGCTAAAAATAAAAACTACAACAGAGTGGAGAAATGCGTTTGTGAAGTA
GAACTACCCACACAAGAGTTAGTTAAGAACTGTTATTATAAGCCATCAATATTACATCTT
TCAGGTGAAGGCAGTGCTAAACTAATGCTCCAAATATCATGGTTCCCTATTGATACAAAA
CAGTTGCCGGCAAATGACCTGATCACAAATTCTGGTGATTTGACGATTATGTCGAGGAGT
GCAGAAAACTTGATAGCATCCGATTTAAATGGTTATTCGGACCCATACTTAAAGTATTAC
ATCAATAATGAGGAAGACTGCGCTTACAAGACGAAGGTTGTTAAGAAAACTTTGAATCCT
AAATGGAATGATGAAGGAACTATTCAAATCAATAACCGTTTAAATGATGTTCTAAGAATC
AAAGTCATGGACTGGGATTCCACATCTGCGGATGATACCATTGGTACAGCAGAAATCCCA
TTGAATAAGGTCAAAGTCGAGGGTACTACCGAATTAGACGTACCGGTAGAAGGATTAGAG
AACGCTGGTCAAGACGGTGGTATGTTGCATTTAGCTTTCAGCTTTAAGCCAAGATACACC
ATTAGCGTGAGTAAAAGAGAAAAGAAGGTCGGAGATATAGCATCCAAGGGACTAGGTACT
GGTTTGAAAGCTGGTACGACCGTGATAGGCGGCGGTGTTGGTGCCATTGGCAAGATCAAG
AAAGGGGTATTCGGTGGACTAGGCAGCCTCACAAACCATAAGAAGAATCATGAGATGGGC
GAAGAAGAAACTAAGTTTTAG
Promoter Sequence
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>TCB1 YOR086C
GAGATCCATTGTTTTCCGGCATGCACTGTTCGTTAGAAATTGGCAAGTGCAAGTCGCCGT
TGGCTGATACCATAATGCTCCTGTTCTAGTAATATTATATTTTATAACTGAATTCTATTG
CCTTACCAAGCCACTGATTAATGACAATTGCATTGAATAGGCTCTAGCTGATCCTCGAAG
GATACTGACTAAATTTACCACATATTTTCAGCTCTTATGAGATAACTCCGACATAGCAAC
AGTGTAGGAGAAAAATTAAAAAATTAACGACCCCAGTGAGGGTTGAACTCACGATCTTGC
GATTAACAGTCGCACGCCTTAACCAACTTGGCCATGGAGTCTAACTTTGTTGTTTTAGAG
AACGAATGAAGAACTTATTATGACGATAAAAATATGTCAAGAGAGGCCCAAGAATGTATA
AATCATTGTAAAACCAAGCAAGTAACAAAAATGGTCATGTGACAAGAGGTGGTGACATAA
AAATAACCAAAGGACTAATAACTAGAGAAACAATAAAATGAGAAACTAAAAAAAGAAATA
AAGCATTGAAAATCTCATTAGACTAGTTGGCTCATTTCCATGGCAAAATGTACAATTGTA
TCTCAGTAACGTTATACTCGCTCCCTTTTTAGGCCAATTTTATCCATTATTCTCATTCTA
AAATAGCGGACATAACGAGAAAACGATTTACGTTAGAAGTGATAACAACTTTGGCGACCG
GAATGCTGCATGAAAAATTATAACAAAAGGCCCCTCAAAAAGCTAAGGGACAGGGATGTT
GCTGCAATTGGAATAGTATAATCGGCCGTCAAAATTATCAACTAATAGCATTGGCTACTC
CAATTTGGACTTACTGGCTGGTAATTGACTTGTATAGCATTGTCTTAGCTTATTATTTTT
TTTTTGCTGAAGAATAAGTAGGATAATTGAAGAAGAATAGCTAAGATAAAAAAAGATAGC
TAGTGCATTCTGAAAACTTCAATTGCGTGGTACATACAAT
Chr coordinates
Chr XV from 486779-483219