Yeastract
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YEASTRACT+ INESC-ID IST IBB
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Locus Information

Standard Name PAC1
Systematic Name YOR269W
Alias LIS1
Strain S288c
Description Regulator of dynein, involved in intracellular transport; part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
External sources Open in SGD external link
Open in KEGG external link
Gene Sequence
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>PAC1 YOR269W
ATGACTAACTGGCAGCAACAGCTTCCTTTAACAGATACACAGAAAAATGAACTCGATAAA
AGTGTCCTCCGATATTTGAATTGGAATTACAAACAAACTGTACGACATGAGCATGCTCAA
GATTACGAAAGTGTTCGACATGCAATTGTAACTCTATCAGGTTTTCTGTTGCAAGAATCA
GTGGACCGGCAAGAATTCATCAGTAACAATGACACCAGTAACGAAAGTATGGTAGACATT
GATGAATTACTGCTACCGAAGAAGTGGAACTCAATTGTTAGACTACAAAAAAAAATCATT
GAATTGGAGCAGAATACAGAGACCCTTGTATCTCAGATTAAAGATTTGAACACTCAAGTG
TCAGAACTAGCACAATTCAAACCTACCACCAGTAACGGCACCAGCGCACATAATGTTTTG
AAATGGATACCGAGAAATCTACCAAGCTGTTTAATTAATGTTGAATCATCTGTCACTTCC
GTCAAACTACATCCCAATTTGCCTATAGTGTTTGTGGCCACAGATCATGGCAAATTATAC
GCATTTGATTTATTTAACTACACCATCCCTCTGGCATCCTTGCAAAGTCATACCAAGGCA
ATTACCTCCATGGATGTTTTATTTACCAATTATACGAACTCCAGCAAGAAGAACTATTTG
GTGATCGTTACCGCGTCTAAAGATTTGCAGATTCATGTTTTCAAGTGGGTCTCCGAGGAA
TGCAAGTTCCAACAAATTAGGTCTTTATTGGGCCATGAGCATATTGTCTCTGCGGTAAAA
ATCTGGCAGAAAAATAATGATGTCCATATAGCGTCCTGTTCCAGAGATCAAACTGTTAAA
ATTTGGGACTTCCACAATGGTTGGTCGTTGAAAACATTTCAGCCTCATTCCCAATGGGTT
CGTTCCATAGACGTTCTAGGCGATTACATCATCTCTGGTTCACATGACACTACATTAAGG
TTAACACATTGGCCATCAGGTAATGGTCTTAGTGTTGGCACGGGTCATGAATTTCCCATA
GAGAAAGTTAAATTTATTCATTTCATCGAAGACTCTCCGGAGATAAGGTTTAGAACACCA
TCAACGGATCGATATAAGAATTGGGGGATGCAATATTGTGTCTCAGCGTCAAGAGATAGA
ACGATAAAAATCTGGGAGATACCTCTACCTACGTTAATGGCCCATAGAGCACCCATACCG
AATCCTACAGATTCAAATTTCAGATGTGTTCTTACGTTGAAGGGGCATCTTTCGTGGGTT
AGAGATATTAGTATTCGAGGCCAATACTTGTTTTCTTGTGCTGATGATAAATCTGTCAGA
TGTTGGGATCTGAACACGGGGCAGTGCTTACACGTTTGGGAAAAGTTGCATACAGGATTT
GTCAACTGTTTAGACCTGGATGTGGATTTCGATTCTAACGTTACCCCAAGGCAAATGATG
GTCACTGGTGGATTGGATTGCAAGTCTAACGTTTTCATGAGATAA
Promoter Sequence
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>PAC1 YOR269W
GGGGCGGCGACGACGTAGGGGTCAGGTAGAAGAGTTGGGCACTTATTGGCGATATAAAAG
ACAAAATACACTAATGCAAGAGTATGGTGAGCGAAAGGAAAATAAAGAAAGGCTACGTTA
TTGACGGATATATGAATCAAGACACAAGACTATTTTGTATAGTAAGCAGAACCGGCTTGT
GTTTGTGATTCATGGATCAACGAGACGGTAGCGAATAAGCACCAACGGAAAAAAAGAAAA
CATACGCATACATGCACGTACAAGATAAAAAAAGCACAGGTGTGGTGGTAGTATTGGGAT
AACCAGGCACACGCTACTGCGAGATAGCAAAAGACCCTTCCCGTAAACCGCTCGGATAAA
CCGATTTTGTCCTTTAGCGTGACACGGATTATACGCGGGGATCCGGCGTCACAAGCCACG
GCCCGTCCCGTCCGCGTGGTTTTTAATTCTGGCTCCGCGTAGTACATTTTGTAGCTTGCC
TTTTTTCCGGCTTCTAGAAAACTGGAAAAACCATAAGAAAAAAATGGGAAGGGGAAAACA
AAAACCATTCAGGTCTTGCGTGCCGAGAATTTTTTTTTTCTCTTTTTCGTTGTCAACTTT
TGCAGTAGCAGCCGCTGGCGACCCGGACGGTAGCCATGGCAACGGTTAGCTAATGGTAGG
TAAATAAAACGAGTAACGACGTTTTAGTATATCTTGGTAAACTACAATTAGATCTTAAAA
CGGTTCCTGAAAAAGTGCTTTCATCTACCATTGAATTTAATTCACTTCCCTTTATGGAAT
TTGCACTGGTTTTGTGCTGTGGGATGTGGGTGTTTTGAAATATTTTCAGCTTGCAAGTCG
TGCATATTGCACTTGTTTCTTATTTTTGGCGAGTGTAAACGTAATAGGTAATCTTAGTAT
TGGGCCATCGTCGCCCAGATAGCCATTGATAAAGCAGCTAGGTTCGTCGTCCGGTTGTTG
GTATACACCTGTGCGTGCGTAAGTGTAGAAAAAAATAGAA
Chr coordinates Chr XV from 826385-827869
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