Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
RAD53 Systematic Name
YPL153C Alias
LSD1, MEC2, SPK1 Strain
S288c Description
DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>RAD53 YPL153C
ATGGAAAATATTACACAACCCACACAGCAATCCACGCAGGCTACTCAAAGGTTTTTGATT
GAGAAGTTTTCTCAAGAACAGATCGGCGAAAACATTGTGTGCAGGGTCATTTGTACCACG
GGTCAAATTCCCATCCGAGATTTGTCAGCTGATATTTCACAAGTGCTTAAGGAAAAACGA
TCCATAAAGAAAGTTTGGACATTTGGTAGAAACCCAGCCTGTGACTATCATTTAGGAAAC
ATTTCAAGACTGTCAAATAAGCATTTCCAAATACTACTAGGAGAAGACGGTAACCTTTTA
TTGAATGACATTTCCACTAATGGGACCTGGTTAAATGGGCAAAAAGTCGAGAAGAACAGC
AATCAGTTACTGTCTCAAGGTGATGAAATAACCGTTGGTGTAGGCGTGGAATCAGATATT
TTATCTCTGGTCATTTTCATAAACGACAAATTTAAGCAGTGCCTCGAGCAGAACAAAGTT
GATCGCATAAGATCTAACCTGAAAAATACCTCTAAAATAGCTTCTCCTGGTCTTACATCA
TCTACTGCATCATCAATGGTGGCCAACAAGACTGGTATTTTTAAGGATTTTTCGATTATT
GACGAAGTGGTGGGCCAGGGTGCATTTGCCACAGTAAAGAAAGCCATTGAAAGAACTACT
GGGAAAACATTCGCGGTGAAGATTATAAGTAAACGCAAAGTAATAGGCAATATGGATGGT
GTGACAAGAGAGTTAGAAGTATTGCAAAAGCTCAATCATCCAAGGATAGTACGATTGAAA
GGATTTTATGAAGATACTGAGAGTTATTATATGGTGATGGAGTTCGTTTCTGGTGGTGAC
TTAATGGATTTTGTTGCTGCTCATGGTGCGGTTGGAGAAGATGCTGGGAGGGAGATATCC
AGGCAGATACTCACAGCAATAAAATACATTCACTCTATGGGCATCAGCCATCGTGACCTA
AAGCCCGATAATATTCTTATTGAACAAGACGATCCTGTATTGGTAAAGATAACCGACTTT
GGTCTGGCAAAAGTACAAGGAAATGGGTCTTTTATGAAAACCTTCTGTGGCACTTTGGCA
TATGTGGCACCTGAAGTCATCAGAGGTAAAGATACATCCGTATCTCCTGATGAATACGAA
GAAAGGAATGAGTACTCTTCGTTAGTGGATATGTGGTCAATGGGATGTCTTGTGTATGTT
ATCCTAACGGGCCACTTACCTTTTAGTGGTAGCACACAGGACCAATTATATAAACAGATT
GGAAGAGGCTCATATCATGAAGGGCCCCTCAAAGATTTCCGGATATCTGAAGAAGCAAGA
GATTTCATAGATTCATTGTTACAGGTGGATCCAAATAATAGGTCGACAGCTGCAAAAGCC
TTGAATCATCCCTGGATCAAGATGAGTCCATTGGGCTCACAATCATATGGTGATTTTTCA
CAAATATCCTTATCACAATCGTTGTCGCAGCAGAAATTATTAGAAAATATGGACGATGCT
CAATACGAATTTGTCAAAGCGCAAAGGAAATTACAAATGGAGCAACAACTTCAAGAACAG
GATCAGGAAGACCAAGATGGAAAAATTCAAGGATTTAAAATACCCGCACACGCCCCTATT
CGATATACACAGCCCAAAAGCATTGAAGCAGAAACTAGAGAACAAAAACTTTTACATTCC
AATAATACTGAGAATGTCAAGAGCTCAAAGAAAAAGGGTAATGGTAGGTTTTTAACTTTA
AAACCATTGCCTGACAGCATTATTCAAGAAAGCCTGGAGATTCAGCAAGGTGTGAATCCA
TTTTTCATTGGTAGATCCGAGGATTGCAATTGTAAAATTGAAGACAATAGGTTGTCTCGA
GTTCATTGCTTCATTTTCAAAAAGAGGCATGCTGTAGGCAAAAGCATGTATGAATCTCCG
GCACAAGGTTTAGATGATATTTGGTATTGCCACACCGGAACTAACGTGAGCTATTTAAAT
AATAACCGCATGATACAGGGTACGAAATTCCTTTTACAAGACGGAGATGAAATCAAGATC
ATTTGGGATAAAAACAATAAATTTGTCATTGGCTTTAAAGTGGAAATTAACGATACTACA
GGTCTGTTTAACGAGGGATTAGGTATGTTACAAGAACAAAGAGTAGTACTTAAGCAAACA
GCCGAAGAAAAAGATTTGGTGAAAAAGTTAACCCAGATGATGGCAGCTCAACGTGCAAAT
CAACCCTCGGCTTCTTCTTCATCAATGTCGGCTAAGAAGCCGCCAGTTAGCGATACAAAT
AATAACGGCAATAATTCGGTACTAAACGACTTGGTAGAGTCACCGATTAATGCGAATACG
GGGAACATTTTGAAGAGAATACATTCGGTAAGTTTATCGCAATCACAAATTGATCCTAGT
AAGAAGGTTAAAAGGGCAAAATTGGACCAAACCTCAAAAGGCCCCGAGAATTTGCAATTT
TCGTAA Promoter Sequence
Download FASTA
>RAD53 YPL153C
CATACTGTTTATTGACTCCGATATTGGTTCTTTGTACTGGGAATTCTCATGTCCTTTGAC
AGATTCAGCCAAATCTATAATAAATTTAGTGAAATGAGCTCTTGTTGGGGATTCTTCCCA
TAGTTTCATATCGTCTGGAGTCAATAGTCTCTTTTCTGGCAACATCTTTTTCTAAATATT
TATATTGTTCTTTACGGATTGTTGTTTATGGACTGTTCTTTCTGCACAGGCGACTAACAT
AAAGTACCTCTCTCTTGTCATTGATATCCCTTTTGTTCTATCACATCCGTTAGGATTTTA
TTCTGTGCTTACTCACGTGAAAGAGAGGGAAGAGTGTAAAAGTTACCCGAAAATCTATTA
TGGCGGCTATTGTAGTACGTCCAAAACAACGTATTTCAATGTAAATTCAAAGCAAACACT
GAGAAAAAACAAAAACTTACTTATTGGTTCGCTCAGCACCTACCTAAATGGTACTTTTAG
AATGATACTGTATTATCTACCGTGGTATCGGCAACTATAGGACGGAGATAAAGCATGCCA
AAGTAATTCTTCCTTTATTAGATGAGATTTCAGCGTGAGGTGAACCATCATTTGTTTGGT
TGGTGCATTAATAGCCTGCTTCCTTTTAATTAAGCCGGAAAGTGTTTGTCACAGATGTCA
ATGAAACGTGCATCTATTAACATATTTATTTTCATTTCGAGGGTGAGGTGGTGTGGACGC
GTTGATACGGCAACGGGAGTGACGCGTAAAATTGGCAGAAAAATCATCACCGTGGGTAGA
CTTGGAAATGAAAACATTTATAGAATAAAGGTACAGGTTGAGAAGATAAAGGGTACCAAA
GTTACCATTTTGAAATCTCTGATCAAGAAAAGGTAAGAAAGCAGAAAAGGACGGTAGAGA
TTATTGGAAGACAAACTAATTTTGTATATGCATTCGATTTTCTTAAGCTTTAAAAGAGAG
AATAGTGAGAAAAGATAGTGTTACACAACATCAACTAAAA
Chr coordinates
Chr XVI from 264192-261727
