Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
SKI3
Systematic Name
YPR189W
Alias
SKI5
Strain
S288c
Description
Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome
External sources
Open in SGD
Open in KEGG
Gene Sequence
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>SKI3 YPR189W
ATGTCGGATATTAAACAGCTATTGAAGGAAGCCAAACAAGAATTGACAAATCGTGACTAT
GAAGAGACCATCGAAATATCGGAAAAGGTTCTTAAACTAGATCCCGATAATTATTTCGCA
CATATTTTTCTAGGGAAAGCACTTTCGAGTCTTCCAGCTAGTAATAATGTCAGTTCAAAT
CGGAACCTGGAGAGAGCTACTAATCATTACGTGTCCGCTGCCAAATTAGTTCCTGATAAC
CTTTTAGCGTGGAAAGGACTTTTTCTCTTATTTAGAACCACTGAGGTTGTCCCAGACATA
CTTTCGTATGATGAATATTTTGACCTGTGTGGCCAATATGCAGACGCACTTTTAAAGCAG
GAACAGTCTCAAGTAGAACTAATAAATGACATAAAATTACTAAAGAAAACGCATCCAGAT
TGTCAAAAAGCCTTTTATCAGCATTTGAAACCTGGGTCGCTAATGGCGGAAACTATTGGT
CGTCATCTATCTACACCCCAGGACGCTTTATTAAATCTTATAAAGATACTGTCTAATATT
GAAACAACGGAAATAGGTAAGACCCTTAGTCAGAACAGGTTAAAACTAAAAGCTAGTGAT
CCTGATTATCAAATTAAACTAAATTCATTCTCCTGGGAAATAATTAAAAATTCAGAAATT
GATCAGTTATACAACCAGTTGGTAAATATTCTCGCTGACGATCAAAAGAGAAGTGAAATT
GAGAACCAGTGGTTAGAATATAGAATCAAAGTGCTAAAATCAATGCCGCTGGATGTAAAA
AAAGATTTTTTCACGAAAGTTAAGGAAATGGTCGAGGATATGGTTCTTGTGAATCATCAA
TCTTTGCTTGCATGGCAAAAGTATTTCGAATGGACAGATTACGAAGATCTGGACAACATG
GATGCCCCATTGATAATAAAGTACTTTAAGAAATTTCCTAAAGATCCATTGGCCATGATC
CTCTATTCCTGGCTTTCCTCAAAACTATCGAAATATGATATTAAAAGTTTGGAATCGGCT
AATAAACCACCTGAAGGCCATAAAAAGACGGAGAAGGAAACAGATATTAAGGATGTAGAT
GAGACAAATGAAGATGAAGTTAAAGATCGCGTTGAAGATGAAGTTAAAGATCGTGTTGAA
GATGAAGTCAAAGATCAAGATGAGGAGGCAAAGGAAGATGAAGAAGAAGACCTTGATGAT
ATAGAAATTGGTTTATTAGAGGAAGAGGTTGTCACTGTATTGACGGAGAATATCGTAAAA
TGTAAAAATAATATCTTAGCGCATCGCATTCTTTGTCAATATTACCTACTGACCAAGGAG
TATGAGGCAGCTTTACCATACATCAAAAATGGTATTTCTTTAATTGCCTATAATATAAAG
GACCTGGGGGTACATTTGCCATTAACAAAAAGAGAATTTTCTCTGGATTTGGCTACCGTT
TATACATATGTCGATGCCCCAAAGGACCACAATGCTGCATTAAAGTTATATGATAACATT
TTATCCGGTGATTTTAGTAATATACAAGCAAAAATGGGCAAAGGTATAATTTTTATTGAA
AGGAAAAATTGGAAGGATGCTATGACATTACTAACACAGGTGCATGAACAATCGCCTAAT
AATCTGGAAGTTTTATCTGAACTGTCATGGAGTAAAGCCCATATGGGTTATATGGACGAG
GCATTAGCTGGCTTAGATACTGTCATCAAGGGTATCAAAGGTATGGATTTACGTTCGATA
GATTTCAGAGCATTAAACTTATGGAGGCAAGCCAAAGTTTACATTATGAAGCATGCTTCC
ATTAACGATGCTAAACAGGAAAACGTCAAGTGCGCATTCAAATTACTCATTCAGAGTATT
AAAATATTGGACACTTTTGCTCCCGGATTTTCGACACTGGGCGATATTTATTGCCACTAT
TATAAAGACCATTTGAGGGCCTTCAAATGTTATTTCAAAGCTTTCGATCTGGATGCGGGG
GATTACACAGCAGCGAAGTATATTACCGAAACTTATGCAAGCAAGCCCAATTGGCAAGCT
GCTTCTTCCATCGCTTCAAGATTAATTAAAGGTGAAAAAGCAAAGGCAGAACTGCGCTCA
AATAACTGGCCCTTTAGGGTCGTAGGGATTGCTCATTTGGAAAAGCAAGAAGAAAGTGAT
TCTATTGAGTGGTTTCAATCTGCTTTACGTGTTGATCCAAATGATGTAGAGTCATGGGTG
GGCCTGGGACAAGCATACCACGCGTGTGGTCGTATAGAAGCATCTATCAAAGTTTTTGAC
AAGGCAATTCAATTAAGGCCCTCTCATACTTTTGCCCAATACTTTAAAGCTATTTCTCTA
TGTGACGTAGGTGAATATCTTGAAAGTTTAGACATTCTGGAAAAGGTATGTCAAGAAGCC
GCTACAGAAGAGTCATTCCAAATTGGTTTAGTGGAAGTGCTTATGAGATGTTCCTTGGAT
TTATATTCGCAAGGGTTCTTGCTCAAATCAGTTTCAATTGCAAAGGACACTATTGAACGG
ATCAAGATAATTATCAGTGAATTAAAATGTGAGAACCAACAGGTTTGGATCTACCTTTCA
CAAGTACTGAGATTATTTATTTGGATAGAGTCAAAGGTTGATACTTTACCTGTTGAATCA
CTAGTATCAATTTTTGAAAATTCTCAATTTTCTGGTAGTGAAGAAATTGATTCTGTCGAC
AATATCAAAATCGATACTTTACTCGATAGCACTACTGATGATAATGTGTCCATTGCGTGC
AAGTTTTTGATCTTAGCTTCAAAATATAGTGTTTCGGATCAAAAATTTACAGATATAGCA
GGAACGGTCAGGGCCTCATACTGGTATAATATAGGTATCTCAGAGCTTACTGCTTTCATA
ACATTGAAAGAACCGCAGTATAGAGATGCTGCTATTTTTGCTTTTAAGAAATCCATTCAA
TTACAGTCTAATACAAGTGAAACTTGGATTGGTCTAGGGATAGCCACTATGGACATCAAC
TTTCGTGTCTCTCAACATTGCTTTATTAAAGCAACTGCTTTGGAACCGAAGGCGACAAAT
ACATGGTTCAACTTGGCTATGCTAGGTTTAAAGAAAAAGGATACTGAATTTGCTCAACAG
GTTCTGAATAAATTACAAAGCCTTGCCCCACAAGATTCGTCACCTTGGCTAGGTATGGCC
TTGATTCTTGAGGAACAAGGAGACATTATCGGAAGTTCTAAACTTTTTGCACACTCCTTC
ATATTATCTAATGGAAGGTCAAAGGCTGCGCAATTTATGTATGCTAAAAATGTCCTTGAG
AATCACATTAATAATGGTGACGATGAAAGAGATATTGAGACAGTGGAAAAACTAACCACT
GCTTCAATAGCTTTAGAGCAGTTTTTCAAAAAAAGTCCTGATAGTCAATTTGCTCTTCAA
TGTGCTCTTCTAACTCTTGAAAGGTTACATCACTATGAAAATGCAAACGAACTGGCTAAT
CGGTTGATAGGCATTTTGGAAAAAAAGTTTGAGAAAACTCAAGATGAAAGAGAACTGTTT
AATTTTGCGATAATTAAAGGACAATTCGCTCGTATTCACTTAGGTTTAGGAAATTTCGAA
CTCTCTATTGAAAACGCTGATCTTTCTCAAGGTATTATATCTGAATCGAGCGACGAAAAA
TCAATGAAAACCAAAATATCCAATCACATTTGCTTAGGATTAAGTTATTTCTTCTTAAAC
GACTTTGATCAGACTTTGAACCAATTCCAAGAACTGCTAAGCATTTCAAAGGATTCTAAG
CACCTAGTTGTTTTAATTGCGAAGGTGCTTTATGATGTAGGTGAATCTGACACAAAGGAA
ATTGCTTTACAGGAACTAACAGAATATATAGCCACAAGCGGCGCAGACTTGTTAGTAACA
CTAACGATTGCAGCTATGTCAATTCTAGACGATAAGCGTGAAGATTTAAGCATTATTTTA
GAAGAATTGAAAGCTTTGCCATTATCCAAACAAATAATAGATAAGCACAAAGACGCACCA
TATCTGATAGAAGAAATTACTAAGAGACTTTATCGTAACGATACCGGTAAACAAGTATGG
CAAAGGAGTGCGTACTTTTTCCCTAATAACCTCAAGGTTTGGGAGAGATTAGATAAGAAT
ATTCAACGAAGAATAGCTTCTAATGGACAAAATAAAGTTACTGCGGAGGAGATGAGTAAA
CTATATTGTGAGAGTAAGAATTTGAGAAGCATACAAAGAGGTATGTTTTTGTGCCCTTGG
AACGTTACTGCAGTGAAGGCGCTAAACGAATGTTTCTAA
Promoter Sequence
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>SKI3 YPR189W
TAGAAGGTGAAACTGATCCATTGCGTATTGCCATGAAGGAGTTGGCTGAAAAGAAAATTC
CTTTGGTTATTAGAAGATATTTACCAGATGGTTCCTTTGAGGACTGGAGTGTGGAGGAAC
TCATTGTGGATTTGTGATTACACCTGCATTTTCCTTTATGTGTATTTGCTTTGTTTGTAT
ATTATTATAACTATAAAGAACGATTTATTTTGTAATGCAAATAACTGGACGAGAGAACCA
CGCTATAACCTATTTGGTAATAAAAATGTTTGTATGAATAAAAAAGCTGCTGACTGCTTT
CTTTGATATGTGTATATAGAATATTTAATCGGTGATTGAATCTAAGAAAAGCTTACCTCT
GAAAGTTCTCTCTTCGGTCGCTTGCTGATTTGTAGTAAACAATTTGAAAAGTTTAGCAAA
TTCTTCCTCAGGATTTTCAAAACCGGCTTCCTTTAAAGAATCAATGACCTCATTCAAGGG
AACGTTTAAATCGTGTCCTCTTCCAATGGCTTTTAAACTTTCTTCCAATTCTTCACGCTC
GGGAAACTGCGATAAGTTCTTCCCCATGATAGATAAGAATATGGGAAAGCTTACACCTTC
TTCTCCAACTTCCGCGGTACTGGTGTCATTGTCAGGTACCATTTTGGACCATTCCTCATC
TGTCAATGTCTTCCCCAATGTTGCATATATCTTGGTAAGATCTCCCCTACTAATCAGACC
ATCCTCATCCTCATCCAGCATTTGGAAAGCATCTTTGAGTTTATTTATGTAGTCCTGCGT
AAGTTGGTTAAACGTTAGCGATTCACTATGGTCCATATCTACTTCAAGTTTGCTCAATAA
ACGATTCGAAATTACTCTTTTCTTAGCTGTGCATTGTATAGTTTAGAAATACGAGAAATG
TAAAAAAAAAAATAAAGTTGGAAAACAACTAACTAATAAAACTTTCTTGTCAAGAAAGAC
ACTAAGAACACAGAAAAGAAACACGAAGAGCAGAGGAAAT
Chr coordinates
Chr XVI from 912664-916962