S.cerevisiae - Yeastract

Regulation Reference(s)

The Yeastract team, is actively curating each regulation evidence code, association type and environmental condition.

Transcription Factor	Target ORF/Genes	References	Evidence Code	Evidence Experiment	Association Type	Strain	Environmental Condition
Gcn4p	YIR019C	PubMed Kleinschmidt M et al., Mol Genet Genomics, 2005 Jun;273(5):382-93	Indirect	Microarray analysis - wt vs TF mutant	Positive	S288c	3-aminotriazole
		PubMed Moxley JF et al., Proc Natl Acad Sci U S A, 2009 Apr 21;106(16):6477-82	Indirect	Microarray analysis - wt vs TF mutant	Positive	BY4741	YNB media
		PubMed Staschke KA et al., J Biol Chem, 2010 May 28;285(22):16893-911	Indirect	Microarray analysis - wt vs TF mutant	Negative	EG328-1A	RNA prepared from wt and DELTAgcn4 cells treated for 1 h with 10 mM 3-AT
		PubMed Herzog B et al., J Mol Biol, 2011 Jan 28;405(4):909-25	Indirect	lacZ - wt vs TF mutant	Positive	S288c	3-aminotriazole
		PubMed Fendt SM et al., Mol Syst Biol, 2010;():	Indirect	Microarray analysis - wt vs TF mutant	Negative	S288c	YPD medium; mid-log phase
		PubMed Herzog B et al., Eukaryot Cell, 2013 Aug;12(8):1142-54	Indirect	lacZ - wt vs TF mutant	Positive	S288c	aminoacid starvation (3-amino-1,2,4-triazole)
		PubMed Wang LC et al., Biomed Res Int, 2015;():	Direct	ChIP	Positive	S288c	Cells haploids and diploids; Amino acid starvation condition induced by 3-amino-1,2,4-triazole (3AT)
		PubMed Walvekar AS et al., Mol Biol Cell, 2018 Oct 24;29(26):3183-3200	Indirect	RNA-seq - wt vs TF mutant	Positive	CEN.PK	RM (1% yeast extract, 2% peptone, and 2% lactate) medium grown cells shifted to MM (0.17% yeast nitrogen base without amino acids, 0.5% ammonium sulfate, and 2% lactate) medium with methionine supplementation