S.cerevisiae - Yeastract

Regulation Reference(s)

The Yeastract team, is actively curating each regulation evidence code, association type and environmental condition.

Transcription Factor	Target ORF/Genes	References	Evidence Code	Evidence Experiment	Association Type	Strain	Environmental Condition
Yap1p	YGR209C	PubMed Stephen DW et al., Mol Microbiol, 1995 May;16(3):415-23	Indirect	lacZ - wt vs TF mutant	Positive	S288c	response to oxidative stress (1h treatment with H2O2); cells grown aerobically to early exponential phase
		PubMed Kuge S et al., EMBO J, 1994 Feb 1;13(3):655-64	Indirect	Northern blot - wt vs TF mutant	Positive	S288c	growth in SD medium with t-butyl hydroperoxide
		PubMed Morgan BA et al., EMBO J, 1997 Mar 3;16(5):1035-44	Indirect	Northern blot - wt vs TF mutant	Positive	S288c	oxidative stress
		PubMed Lee J et al., J Biol Chem, 1999 Jun 4;274(23):16040-6	Indirect	Northern blot - wt vs TF mutant	Positive	S288c	20 minutes exposure to 0.2 mM H2O2 (SC growth medium)
		PubMed Charizanis C et al., Mol Gen Genet, 1999;():	N/A		N/A	S288c	N/A
		PubMed Dumond H et al., Mol Microbiol, 2000 May;36(4):830-45	Indirect	Microarray analysis - wt vs TF mutant	Positive	W303a	Exponential cells grown in galactose minimal medium followed by oxidative stress (0.4mM H2O2)
		PubMed Ross SJ et al., Mol Biol Cell, 2000 Aug;11(8):2631-42	Indirect	Northern blot - wt vs TF mutant	Positive	S288c	midlog-phase growing cultures treated with 0.1 mM H2O2 for 20 min
		PubMed Delaunay A et al., EMBO J, 2000 Oct 2;19(19):5157-66	Indirect	RT-PCR - wt vs TF mutant	Positive	S288c	H2O2 treatment
		PubMed Vido K et al., J Biol Chem, 2001 Mar 16;276(11):8469-74	Indirect	Proteomics - wt vs TF mutant	Positive	YPH98	Exponential-phase cells; 1 mM Cd
		PubMed Wysocki R et al., Mol Biol Cell, 2004 May;15(5):2049-60	Indirect	Northern blot - wt vs TF mutant	Positive	S288c	Arsenite stress; Exponential-phase cells cultivated in YNB growth medium supplemented with 1 mM sodium arsenite
		PubMed Harbison CT et al., Nature, 2004 Sep 2;431(7004):99-104	Direct	Chip-on-chip	N/A	S288c	N/A
		PubMed Haugen AC et al., Genome Biol, 2004;5(12):R95	Indirect	Microarray analysis - wt vs TF mutant	Positive	BY4741	Synthetic complete medium after 2h exposure to 100 microM AsIII (30.C).
		PubMed Takatsume Y et al., J Agric Food Chem, 2005 Jan 26;53(2):332-7	N/A		N/A	S288c	N/A
		PubMed Lucau-Danila A et al., Mol Cell Biol, 2005 Mar;25(5):1860-8	Indirect	Microarray analysis - wt vs TF mutant	Positive	S288c	YPD medium + 20 mg/L benomyl
		PubMed Dubacq C et al., Mol Genet Genomics, 2006 Feb;275(2):114-24	Indirect	Microarray analysis - wt vs TF mutant	Positive	S288c	YPD medium + 200mM hydroxyurea
		PubMed Workman CT et al., Science, 2006 May 19;312(5776):1054-9	Direct	Chip-on-chip	N/A	S288c	N/A
		PubMed Paes de Faria J et al., Free Radic Biol Med, 2006 Dec 1;41(11):1684-93	Indirect	Northern blot - wt vs TF mutant	Positive	S288c	H2O2 treatment
		PubMed Thorsen M et al., Physiol Genomics, 2007 Jun 19;30(1):35-43	Indirect	Microarray analysis - wt vs TF mutant	Positive	W303-1A	1.0 mM As(III), 1 h
		PubMed Okazaki S et al., Mol Cell, 2007 Aug 17;27(4):675-88	Indirect	Northern blot - wt vs TF mutant	Positive	BY4742	cells expressing GFP-fused Yap1 versus cells expressing GFP-fused Yap1 (CTT,CAT) with mutated cysteine and alanine residues
		PubMed Ng CH et al., Free Radic Biol Med, 2008 Mar 15;44(6):1131-45	Indirect	lacZ - wt vs TF mutant	Positive	BY4743	wt vs yap1skn7DELTA double deletion mutant ( no information available in the article regarding each single gene deletion) SD media mid exp cells
		PubMed Tan K et al., Proc Natl Acad Sci U S A, 2008 Feb 26;105(8):2934-9	Direct	Chip-on-chip	N/A	S288c	SC medium + MMS (methylmethanesulfonate)
		PubMed Menezes RA et al., Biochem J, 2008 Sep 1;414(2):301-11	Indirect	RT-PCR - wt vs TF mutant	Positive	BY4741	2mM Na2HAsO or NaAsO2
		PubMed Salin H et al., BMC Genomics, 2008 Jul 15;0(0):33	Direct	Chip-on-chip	N/A	BY4742	YPD + Sodium selenite (1 mM), hydrogen peroxide (0.3 mM) or benomyl (20 microg/ml)
			Indirect	Microarray analysis - wt vs TF mutant	Negative	BY4742	YPD
			Indirect	Microarray analysis - wt vs TF mutant	Negative	BY4742	YPD+1mM selenite 40 min
			Indirect	Microarray analysis - wt vs TF mutant	Negative	BY4742	YPD+1mM selenite 60 min
			Indirect	Microarray analysis - wt vs TF mutant	Negative	BY4742	YPD+1mM selenite 80 min
		PubMed He XJ et al., Eukaryot Cell, 2009 May;8(5):768-78	Direct	EMSA	N/A	S288c	N/A
		PubMed Kelley R et al., PLoS Genet, 2009 May;5(5):e1000488	Indirect	Microarray analysis - wt vs TF mutant	Positive	BY4741	YPD 30.C from 0.1 mM H2O2 to 0.4 mM H2O2
		PubMed Iwai K et al., J Biol Chem, 2010 Apr 2;285(14):10597-604	Direct	ChIP	N/A	S288c	H2O2 treatment
		PubMed Reimand J et al., Nucleic Acids Res, 2010 Aug;38(14):4768-77	Indirect	Microarray analysis - wt vs TF mutant	Positive	S288c	YPD medium; mid-log phase
		PubMed EscotÃ© X et al., Yeast, 2012 Jul;29(7):251-63	Indirect	RT-PCR - wt vs TF mutant	Positive	S288c	resveratrol stress
		PubMed Pimentel C et al., Biochim Biophys Acta, 2014 Jun;1840(6):1977-86	Indirect	RT-PCR - wt vs TF mutant	Positive	S288c	2 mM CoSO4
		PubMed Mazzola D et al., FEBS Lett, 2015;():Mazzola D et al., FEBS Lett, 2015;():	Indirect	RT-PCR - wt vs TF mutant	Positive	S288c	Strains were grown in SC medium
		PubMed Zhang C et al., Yeast, 2016 Jan;33(1):5-19	Indirect	RNA-seq - wt vs TF mutant	Positive	S288c	SD medium + MMS
		PubMed Suzuki H et al., Appl Microbiol Biotechnol, 2017 Jan;101(2):659-671	Indirect	Luciferase - wt vs TF mutant	Positive	BY4741	Cells expressing pESC-HISDELTAGAL1/10 with a RNR3 promoter-linked luc2CP (unstable luciferase) gene grown in SD medium (with luciferin and no histidine), treated with 0.1 mM H2O2
		PubMed Shedlovskiy D et al., J Biol Chem, 2017 Nov 10;292(45):18469-18485	Indirect	RT-PCR - wt vs TF mutant	Positive	BY4741	YPDA medium (1% yeast extract, 2% peptone, 2% dextrose, 10 mg/L adenine) treated with 0.2 mM H2O2 (oxidative stress) for 30 min
		PubMed da Silva SM et al., Biochim Biophys Acta Gen Subj, 2018 Oct;1862(10):2152-2161	Indirect	Microarray analysis - wt vs TF mutant	Positive	BY4741	YPD + 2â€¯mM arsenic
		PubMed Rossi MJ et al., Nature, 2021 Apr;592(7853):309-314	Direct	ChIP-exo	N/A	BY4741	YPD medium, 25.C